Entrez Gene

Basic Information
Gene ID	6790
Name	AURKA
Synonymous	aurora kinase A;AURKA;aurora kinase A
Definition	ARK-1\|Aurora-A kinase\|IPL1-related kinase\|aurora 2\|aurora-related kinase 1\|aurora/IPL1-like kinase\|aurora/IPL1-related kinase 1\|breast tumor-amplified kinase\|breast-tumor-amplified kinase\|hARK1\|protein phosphatase 1, regulatory subunit 47\|serine/threonine
Position	20q13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.266C>G; p.S89C; 20:56386310-56386310	breast	carcinoma	Substitution - Missense
c.293G>A; p.S98N; 20:56386283-56386283	breast	carcinoma	Substitution - Missense
c.242C>T; p.A81V; 20:56386334-56386334	breast	carcinoma	Substitution - Missense
c.256C>T; p.H86Y; 20:56386320-56386320	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.11C>A; p.S4Y; 20:56388187-56388187	breast	carcinoma	Substitution - Missense
c.681G>T; p.K227N; 20:56381457-56381457	central_nervous_system; brain	glioma	Substitution - Missense
c.1160C>T; p.S387L; 20:56370210-56370210	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.158C>A; p.S53Y; 20:56386418-56386418	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.454G>T; p.E152*; 20:56383097-56383097	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.168C>T; p.R56R; 20:56386408-56386408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.746C>T; p.S249L; 20:56373516-56373516	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.800C>T; p.A267V; 20:56373462-56373462	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.736T>C; p.Y246H; 20:56373526-56373526	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.736T>C; p.Y246H; 20:56373526-56373526	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.522G>A; p.V174V; 20:56383029-56383029	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.522G>A; p.V174V; 20:56383029-56383029	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.665T>C; p.L222P; 20:56381473-56381473	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.998C>T; p.T333I; 20:56370516-56370516	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.998C>T; p.T333I; 20:56370516-56370516	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.768_781del14; p.D256fs*11; 20:56373481-56373494	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.747G>A; p.S249S; 20:56373515-56373515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.780G>T; p.E260D; 20:56373482-56373482	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>A; p.P297H; 20:56370624-56370624	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>A; p.P297H; 20:56370624-56370624	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.793G>T; p.G265*; 20:56373469-56373469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.168C>T; p.R56R; 20:56386408-56386408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.794G>A; p.G265E; 20:56373468-56373468	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.167G>A; p.R56H; 20:56386409-56386409	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.S249L; 20:56373516-56373516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.463A>G; p.S155G; 20:56383088-56383088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.463A>G; p.S155G; 20:56383088-56383088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.817G>A; p.A273T; 20:56373445-56373445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1083A>G; p.S361S; 20:56370287-56370287	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.793G>A; p.G265R; 20:56373469-56373469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1075C>T; p.L359F; 20:56370295-56370295	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.463A>C; p.S155R; 20:56383088-56383088	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.463A>C; p.S155R; 20:56383088-56383088	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1149C>A; p.I383I; 20:56370221-56370221	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1193C>A; p.S398*; 20:56370177-56370177	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.464G>A; p.S155N; 20:56383087-56383087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.125G>A; p.G42D; 20:56386451-56386451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.253C>T; p.P85S; 20:56386323-56386323	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.28T>C; p.S10P; 20:56388170-56388170	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.28T>C; p.S10P; 20:56388170-56388170	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>T; p.V174V; 20:56383029-56383029	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.42+1G>C; p.?; 20:56388155-56388155	lung	carcinoma; small_cell_carcinoma	Unknown
c.830G>T; p.W277L; 20:56373432-56373432	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>T; p.G11*; 20:56388167-56388167	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1082C>G; p.S361*; 20:56370288-56370288	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.1082C>G; p.S361*; 20:56370288-56370288	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.1082C>G; p.S361*; 20:56370288-56370288	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.1082C>G; p.S361*; 20:56370288-56370288	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.1193C>T; p.S398L; 20:56370177-56370177	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.141C>G; p.V47V; 20:56386435-56386435	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.736T>C; p.Y246H; 20:56373526-56373526	NS	malignant_melanoma	Substitution - Missense
c.1154C>A; p.A385E; 20:56370216-56370216	oesophagus	carcinoma	Substitution - Missense
c.869G>T; p.C290F; 20:56370645-56370645	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.932A>T; p.D311V; 20:56370582-56370582	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.913A>T; p.M305L; 20:56370601-56370601	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.795A>G; p.G265G; 20:56373467-56373467	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.952C>G; p.L318V; 20:56370562-56370562	ovary	other; neoplasm	Substitution - Missense
c.855-6T>G; p.?; 20:56370665-56370665	pancreas	carcinoma	Unknown
c.836T>C; p.V279A; 20:56373426-56373426	prostate	carcinoma	Substitution - Missense
c.646G>A; p.G216R; 20:56381492-56381492	skin	malignant_melanoma	Substitution - Missense
c.663A>G; p.E221E; 20:56381475-56381475	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.785T>G; p.L262*; 20:56373477-56373477	skin	malignant_melanoma	Substitution - Nonsense
c.35C>T; p.P12L; 20:56388163-56388163	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>A; p.R205K; 20:56381524-56381524	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.91T>A; p.F31I; 20:56386485-56386485	skin	malignant_melanoma	Substitution - Missense
c.132T>G; p.A44A; 20:56386444-56386444	skin	malignant_melanoma	Substitution - coding silent
c.772_773AA>GC; p.K258A; 20:56373489-56373490	skin	malignant_melanoma	Substitution - Missense
c.11C>T; p.S4F; 20:56388187-56388187	skin; trunk	malignant_melanoma	Substitution - Missense
c.94C>T; p.P32S; 20:56386482-56386482	skin	malignant_melanoma	Substitution - Missense
c.520G>A; p.V174M; 20:56383031-56383031	skin	malignant_melanoma	Substitution - Missense
c.520G>A; p.V174M; 20:56383031-56383031	skin	malignant_melanoma	Substitution - Missense
c.520G>A; p.V174M; 20:56383031-56383031	skin	malignant_melanoma	Substitution - Missense
c.520G>A; p.V174M; 20:56383031-56383031	skin	malignant_melanoma	Substitution - Missense
c.594T>G; p.G198G; 20:56381544-56381544	skin	malignant_melanoma	Substitution - coding silent
c.241G>A; p.A81T; 20:56386335-56386335	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.251T>A; p.V84E; 20:56386325-56386325	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.354G>A; p.Q118Q; 20:56384290-56384290	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.747G>A; p.S249S; 20:56373515-56373515	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.603T>C; p.H201H; 20:56381535-56381535	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.166C>T; p.R56C; 20:56386410-56386410	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.617T>C; p.V206A; 20:56381521-56381521	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.21C>T; p.N7N; 20:56388177-56388177	thyroid	other; neoplasm	Substitution - coding silent
c.624A>G; p.L208L; 20:56381514-56381514	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.624A>G; p.L208L; 20:56381514-56381514	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.969A>C; p.L323F; 20:56370545-56370545	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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