Entrez Gene

Basic Information
Gene ID	6774
Name	STAT3
Synonymous	signal transducer and activator of transcription 3 (acute-phase response factor);STAT3;signal transducer and activator of transcription 3 (acute-phase response factor)
Definition	DNA-binding protein APRF\|acute-phase response factor\|signal transducer and activator of transcription 3
Position	17q21.31
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.966G>T; p.V322V; 17:42333756-42333756	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.707C>T; p.T236M; 17:42337525-42337525	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.2187C>T; p.R729R; 17:42316859-42316859	breast	carcinoma	Substitution - coding silent
c.2171T>C; p.L724P; 17:42316875-42316875	breast	carcinoma	Substitution - Missense
c.1229A>G; p.H410R; 17:42329558-42329558	breast	carcinoma	Substitution - Missense
c.1957A>G; p.I653V; 17:42322426-42322426	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1151T>A; p.F384Y; 17:42329636-42329636	breast	carcinoma	Substitution - Missense
c.364G>A; p.A122T; 17:42345567-42345567	breast	carcinoma	Substitution - Missense
c.1268G>A; p.R423Q; 17:42329423-42329423	breast	carcinoma	Substitution - Missense
c.1767C>G; p.I589M; 17:42323125-42323125	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1922C>T; p.T641I; 17:42322461-42322461	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.92G>A; p.R31Q; 17:42348425-42348425	central_nervous_system; brain	glioma	Substitution - Missense
c.64T>C; p.Y22H; 17:42348453-42348453	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.627G>A; p.A209A; 17:42337781-42337781	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1704C>A; p.I568I; 17:42323304-42323304	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1924A>G; p.K642E; 17:42322459-42322459	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2103C>T; p.S701S; 17:42317223-42317223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1487C>T; p.P496L; 17:42324824-42324824	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.225G>A; p.S75S; 17:42346617-42346617	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2023C>T; p.P675S; 17:42322360-42322360	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1465-1G>T; p.?; 17:42324847-42324847	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.250C>T; p.R84*; 17:42346592-42346592	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.984C>T; p.C328C; 17:42333738-42333738	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.832C>T; p.R278C; 17:42334015-42334015	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1777C>T; p.R593W; 17:42323115-42323115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1273A>G; p.N425D; 17:42329418-42329418	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283C>T; p.L95F; 17:42345648-42345648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1844_1846delAAG; p.E616del; 17:42323046-42323048	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Deletion - In frame
c.1852G>C; p.G618R; 17:42323040-42323040	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; anaplastic_large_cell_lymphoma	Substitution - Missense
c.1844_1846delAAG; p.E616del; 17:42323046-42323048	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Deletion - In frame
c.1852G>C; p.G618R; 17:42323040-42323040	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1982A>T; p.D661V; 17:42322401-42322401	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1982A>T; p.D661V; 17:42322401-42322401	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1982A>T; p.D661V; 17:42322401-42322401	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1982A>T; p.D661V; 17:42322401-42322401	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1648T>C; p.C550R; 17:42323578-42323578	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; angioimmunoblastic_T_cell_lymphoma	Substitution - Missense
c.1696G>A; p.D566N; 17:42323312-42323312	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1967G>A; p.G656D; 17:42322416-42322416	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hepatosplenic_T_cell_lymphoma	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue; skin	lymphoid_neoplasm; anaplastic_large_cell_lymphoma	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1846G>A; p.E616K; 17:42323046-42323046	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1981G>T; p.D661Y; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>A; p.D661N; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1968_1969insTAT; p.G656_Y657insY; 17:42322414-42322415	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Insertion - In frame
c.1974G>T; p.K658N; 17:42322409-42322409	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1974G>T; p.K658N; 17:42322409-42322409	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1849G>A; p.G617R; 17:42323043-42323043	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1981G>C; p.D661H; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1981G>C; p.D661H; 17:42322402-42322402	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; anaplastic_large_cell_lymphoma	Substitution - Missense
c.1847_1849delAAG; p.E616delE; 17:42323043-42323045	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; angioimmunoblastic_T_cell_lymphoma	Deletion - In frame
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue; skin	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK-T_cell_lymphoma	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue; salivary_gland	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue; lung	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hepatosplenic_T_cell_lymphoma	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1919A>T; p.Y640F; 17:42322464-42322464	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue; pleura	lymphoid_neoplasm; anaplastic_large_cell_lymphoma	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK_cell_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1940A>T; p.N647I; 17:42322443-42322443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.617T>A; p.M206K; 17:42337791-42337791	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.2312G>A; p.771; 17:42315746-42315746	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - coding silent
c.1847A>G; p.E616G; 17:42323045-42323045	haematopoietic_and_lymphoid_tissue; sinonasal_and_nasal_cavity	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1842C>G; p.S614R; 17:42323050-42323050	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1842C>G; p.S614R; 17:42323050-42323050	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1842C>G; p.S614R; 17:42323050-42323050	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1842C>G; p.S614R; 17:42323050-42323050	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.1842C>G; p.S614R; 17:42323050-42323050	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; angioimmunoblastic_T_cell_lymphoma	Substitution - Missense
c.1701T>A; p.N567K; 17:42323307-42323307	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1709A>G; p.D570G; 17:42323299-42323299	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1988_1989CC>TT; p.T663I; 17:42322394-42322395	haematopoietic_and_lymphoid_tissue; groin	lymphoid_neoplasm; B_cell_lymphoma_unclassifiable_with_features_intermediate_between_DLBCL_and_Burkitt_lymphoma	Substitution - Missense
c.1946C>T; p.S649L; 17:42322437-42322437	haematopoietic_and_lymphoid_tissue; ovary	lymphoid_neoplasm; B_cell_lymphoma_unclassifiable_with_features_intermediate_between_DLBCL_and_Burkitt_lymphoma	Substitution - Missense
c.877T>A; p.Y293N; 17:42333970-42333970	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1539C>T; p.S513S; 17:42324772-42324772	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1237C>A; p.L413M; 17:42329454-42329454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.377G>A; p.G126E; 17:42339405-42339405	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1465-2A>C; p.?; 17:42324848-42324848	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1217C>T; p.A406V; 17:42329570-42329570	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1131T>C; p.A377A; 17:42329755-42329755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.74G>A; p.S25N; 17:42348443-42348443	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.532delA; p.T178fs*11; 17:42338749-42338749	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2185delC; p.R729fs*3; 17:42316861-42316861	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2185delC; p.R729fs*3; 17:42316861-42316861	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1847_1849delAAG; p.E616delE; 17:42323043-42323045	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.1204G>T; p.G402C; 17:42329583-42329583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.225G>A; p.S75S; 17:42346617-42346617	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1024G>A; p.G342S; 17:42333698-42333698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.268C>A; p.L90I; 17:42346574-42346574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.908C>T; p.P303L; 17:42333939-42333939	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1204G>A; p.G402S; 17:42329583-42329583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>T; p.A46V; 17:42346705-42346705	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1479_1480insT; p.T494fs*55; 17:42324831-42324832	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.927C>T; p.I309I; 17:42333920-42333920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.927C>T; p.I309I; 17:42333920-42333920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>A; p.G402G; 17:42329581-42329581	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1067C>T; p.P356L; 17:42331514-42331514	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.765G>A; p.P255P; 17:42337467-42337467	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.765G>A; p.P255P; 17:42337467-42337467	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.765G>A; p.P255P; 17:42337467-42337467	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1033T>C; p.F345L; 17:42333689-42333689	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1033T>C; p.F345L; 17:42333689-42333689	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1927C>A; p.Q643K; 17:42322456-42322456	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.220G>T; p.E74*; 17:42346622-42346622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1244A>T; p.E415V; 17:42329447-42329447	liver	carcinoma	Substitution - Missense
c.1244A>T; p.E415V; 17:42329447-42329447	liver	carcinoma	Substitution - Missense
c.1967G>A; p.G656D; 17:42322416-42322416	liver	other; adenoma	Substitution - Missense
c.1972_1974AAG>TAT; p.K658Y; 17:42322409-42322411	liver	other; adenoma	Substitution - Missense
c.1968_1968C>TTTT; p.G656_Y657insF; 17:42322415-42322415	liver	other; adenoma	Insertion - In frame
c.468G>A; p.Q156Q; 17:42339314-42339314	liver	carcinoma	Substitution - coding silent
c.1919A>T; p.Y640F; 17:42322464-42322464	liver	other; adenoma	Substitution - Missense
c.1243G>A; p.E415K; 17:42329448-42329448	liver	carcinoma	Substitution - Missense
c.1965G>A; p.M655I; 17:42322418-42322418	liver	other; adenoma	Substitution - Missense
c.496G>C; p.E166Q; 17:42338785-42338785	liver	other; adenoma	Substitution - Missense
c.1287C>A; p.S429S; 17:42326194-42326194	liver	carcinoma	Substitution - coding silent
c.1287C>A; p.S429S; 17:42326194-42326194	liver	carcinoma	Substitution - coding silent
c.1980_1981ins12; p.M660_D661insYKIM; 17:42322402-42322403	liver	other; adenoma	Insertion - In frame
c.134A>G; p.Y45C; 17:42346708-42346708	liver	carcinoma	Substitution - Missense
c.134A>G; p.Y45C; 17:42346708-42346708	liver	carcinoma	Substitution - Missense
c.233T>G; p.L78R; 17:42346609-42346609	liver	other; adenoma	Substitution - Missense
c.1504G>T; p.D502Y; 17:42324807-42324807	liver	other; adenoma	Substitution - Missense
c.377G>A; p.G126E; 17:42339405-42339405	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.545A>G; p.Q182R; 17:42338736-42338736	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2049C>A; p.F683L; 17:42322334-42322334	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1995C>T; p.I665I; 17:42322388-42322388	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.130G>A; p.A44T; 17:42346712-42346712	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1204G>T; p.G402C; 17:42329583-42329583	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.463G>A; p.V155M; 17:42339319-42339319	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1187_1188TG>TA; p.M396>?; 17:42329599-42329600	lung	carcinoma; adenocarcinoma	Complex
c.600G>C; p.M200I; 17:42337808-42337808	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2148G>C; p.T716T; 17:42316898-42316898	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1280A>G; p.D427G; 17:42329411-42329411	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.104C>T; p.A35V; 17:42348413-42348413	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1105G>A; p.D369N; 17:42331476-42331476	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1946C>G; p.S649*; 17:42322437-42322437	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1210C>G; p.L404V; 17:42329577-42329577	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.413C>T; p.T138M; 17:42339369-42339369	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1769G>A; p.S590N; 17:42323123-42323123	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1492A>G; p.I498V; 17:42324819-42324819	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1492A>G; p.I498V; 17:42324819-42324819	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1492A>G; p.I498V; 17:42324819-42324819	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.158C>G; p.A53G; 17:42346684-42346684	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.785G>A; p.R262Q; 17:42337447-42337447	ovary	other; neoplasm	Substitution - Missense
c.37C>T; p.R13W; 17:42348480-42348480	pancreas	carcinoma	Substitution - Missense
c.1374C>T; p.S458S; 17:42325053-42325053	pancreas	carcinoma	Substitution - coding silent
c.1540T>A; p.S514T; 17:42324771-42324771	pancreas	carcinoma	Substitution - Missense
c.789A>G; p.L263L; 17:42337443-42337443	pancreas	carcinoma	Substitution - coding silent
c.1152T>G; p.F384L; 17:42329635-42329635	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1552C>T; p.R518*; 17:42324759-42324759	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1255G>T; p.G419W; 17:42329436-42329436	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1826G>C; p.R609T; 17:42323066-42323066	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1953T>C; p.A651A; 17:42322430-42322430	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.137C>T; p.A46V; 17:42346705-42346705	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1414A>G; p.N472D; 17:42325013-42325013	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1144C>T; p.R382W; 17:42329643-42329643	prostate	carcinoma	Substitution - Missense
c.2295C>T; p.C765C; 17:42315763-42315763	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - coding silent
c.1735C>T; p.L579F; 17:42323273-42323273	skin	malignant_melanoma	Substitution - Missense
c.347T>C; p.L116P; 17:42345584-42345584	skin	malignant_melanoma	Substitution - Missense
c.1895C>T; p.T632I; 17:42322488-42322488	skin	malignant_melanoma	Substitution - Missense
c.1005G>A; p.R335R; 17:42333717-42333717	skin	malignant_melanoma	Substitution - coding silent
c.946T>A; p.L316I; 17:42333901-42333901	skin	malignant_melanoma	Substitution - Missense
c.1066C>T; p.P356S; 17:42331515-42331515	skin	malignant_melanoma	Substitution - Missense
c.2303C>T; p.S768F; 17:42315755-42315755	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1912G>A; p.E638K; 17:42322471-42322471	skin	malignant_melanoma	Substitution - Missense
c.1122C>T; p.D374D; 17:42329764-42329764	skin	malignant_melanoma	Substitution - coding silent
c.1481C>T; p.T494I; 17:42324830-42324830	skin	malignant_melanoma	Substitution - Missense
c.159C>T; p.A53A; 17:42346683-42346683	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1317C>T; p.I439I; 17:42326164-42326164	skin	malignant_melanoma	Substitution - coding silent
c.79C>T; p.P27S; 17:42348438-42348438	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.78C>T; p.F26F; 17:42348439-42348439	skin	malignant_melanoma	Substitution - coding silent
c.1728C>T; p.I576I; 17:42323280-42323280	skin	malignant_melanoma	Substitution - coding silent
c.1428C>T; p.S476S; 17:42324999-42324999	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2049C>T; p.F683F; 17:42322334-42322334	skin	malignant_melanoma	Substitution - coding silent
c.238C>T; p.Q80*; 17:42346604-42346604	skin	malignant_melanoma	Substitution - Nonsense
c.1449G>A; p.L483L; 17:42324978-42324978	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1981G>T; p.D661Y; 17:42322402-42322402	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1840A>C; p.S614R; 17:42323052-42323052	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1961T>C; p.I654T; 17:42322422-42322422	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1516G>A; p.E506K; 17:42324795-42324795	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1576A>G; p.T526A; 17:42324735-42324735	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.834T>C; p.R278R; 17:42334013-42334013	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1920C>T; p.Y640Y; 17:42322463-42322463	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2289G>A; p.S763S; 17:42315769-42315769	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.722C>A; p.A241D; 17:42337510-42337510	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.994C>T; p.H332Y; 17:42333728-42333728	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1409T>G; p.M470R; 17:42325018-42325018	thyroid	other; neoplasm	Substitution - Missense
c.189G>C; p.E63D; 17:42346653-42346653	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.189G>C; p.E63D; 17:42346653-42346653	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.469-2A>G; p.?; 17:42338814-42338814	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.2185_2186insC; p.R729fs*12; 17:42316860-42316861	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1922C>G; p.T641R; 17:42322461-42322461	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1922C>G; p.T641R; 17:42322461-42322461	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense

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COSMIC confirmed somatic mutation [Top]

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