Entrez Gene

Basic Information
Gene ID	6678
Name	SPARC
Synonymous	secreted protein, acidic, cysteine-rich (osteonectin);SPARC;secreted protein, acidic, cysteine-rich (osteonectin)
Definition	BM-40\|basement-membrane protein 40\|cysteine-rich protein\|osteonectin\|secreted protein acidic and rich in cysteine
Position	5q31.3-q32
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.375C>G; p.F125L; 5:151669740-151669740	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.454A>G; p.I152V; 5:151667598-151667598	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.586-3C>T; p.?; 5:151666512-151666512	breast	carcinoma	Unknown
c.730G>A; p.D244N; 5:151666365-151666365	breast	carcinoma	Substitution - Missense
c.513C>G; p.L171L; 5:151667539-151667539	breast	carcinoma	Substitution - coding silent
c.829A>G; p.N277D; 5:151664141-151664141	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.503G>T; p.R168L; 5:151667549-151667549	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.380C>T; p.A127V; 5:151669735-151669735	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.626G>T; p.G209V; 5:151666469-151666469	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.157G>T; p.G53*; 5:151673180-151673180	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.187G>T; p.E63*; 5:151673150-151673150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.393C>T; p.T131T; 5:151669722-151669722	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.250G>A; p.E84K; 5:151671653-151671653	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.449A>G; p.K150R; 5:151669666-151669666	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.761C>A; p.P254Q; 5:151664209-151664209	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.603G>T; p.E201D; 5:151666492-151666492	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.469G>A; p.D157N; 5:151667583-151667583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.513C>T; p.L171L; 5:151667539-151667539	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - coding silent
c.358G>A; p.D120N; 5:151669757-151669757	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.816C>A; p.T272T; 5:151664154-151664154	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.131G>A; p.G44E; 5:151673206-151673206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.279C>T; p.C93C; 5:151671624-151671624	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.661G>A; p.E221K; 5:151666434-151666434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>A; p.A282T; 5:151664126-151664126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>A; p.A282T; 5:151664126-151664126	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>A; p.A282T; 5:151664126-151664126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.679T>C; p.Y227H; 5:151666416-151666416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.705C>T; p.F235F; 5:151666390-151666390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.23T>A; p.L8H; 5:151676166-151676166	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.122T>C; p.V41A; 5:151673215-151673215	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.E84K; 5:151671653-151671653	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.E84K; 5:151671653-151671653	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.497G>A; p.R166H; 5:151667555-151667555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.840C>T; p.Y280Y; 5:151664130-151664130	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.636C>T; p.P212P; 5:151666459-151666459	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.538G>A; p.E180K; 5:151667514-151667514	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.18C>A; p.F6L; 5:151676171-151676171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.357C>T; p.F119F; 5:151669758-151669758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.732C>T; p.D244D; 5:151666363-151666363	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.550G>A; p.D184N; 5:151667502-151667502	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.860C>T; p.A287V; 5:151664110-151664110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.261G>T; p.E87D; 5:151671642-151671642	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>T; p.E54*; 5:151673177-151673177	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.584G>A; p.R195Q; 5:151667468-151667468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.637G>T; p.V213L; 5:151666458-151666458	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.821A>C; p.D274A; 5:151664149-151664149	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.117T>A; p.T39T; 5:151674615-151674615	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.595A>G; p.I199V; 5:151666500-151666500	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.310C>A; p.P104T; 5:151671593-151671593	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.826G>T; p.D276Y; 5:151664144-151664144	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.352A>G; p.T118A; 5:151669763-151669763	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.335G>T; p.C112F; 5:151669780-151669780	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.407A>C; p.K136T; 5:151669708-151669708	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.23T>A; p.L8H; 5:151676166-151676166	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.529A>T; p.T177S; 5:151667523-151667523	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.186C>T; p.T62T; 5:151673151-151673151	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - coding silent
c.652C>T; p.R218W; 5:151666443-151666443	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.663G>C; p.E221D; 5:151666432-151666432	skin	malignant_melanoma	Substitution - Missense
c.491C>T; p.P164L; 5:151667561-151667561	skin	malignant_melanoma	Substitution - Missense
c.484G>C; p.E162Q; 5:151667568-151667568	skin	malignant_melanoma	Substitution - Missense
c.576G>A; p.Q192Q; 5:151667476-151667476	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.749C>T; p.T250I; 5:151664221-151664221	skin	malignant_melanoma	Substitution - Missense
c.750C>T; p.T250T; 5:151664220-151664220	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.787G>A; p.E263K; 5:151664183-151664183	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>A; p.A282T; 5:151664126-151664126	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>A; p.V50V; 5:151673187-151673187	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.280G>A; p.V94M; 5:151671623-151671623	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.694C>T; p.H232Y; 5:151666401-151666401	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.860C>T; p.A287V; 5:151664110-151664110	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.54C>G; p.A18A; 5:151676135-151676135	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.54C>G; p.A18A; 5:151676135-151676135	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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