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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

6495

Name

SIX1

Synonymous

SIX homeobox 1;SIX1;SIX homeobox 1

Definition

homeobox protein SIX1|sine oculis homeobox homolog 1

Position

14q23.1

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.100C>A; p.L34M; 14:60649090-60649090

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.284C>T; p.A95V; 14:60648906-60648906

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.338G>A; p.R113Q; 14:60648852-60648852

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.746C>A; p.P249Q; 14:60646392-60646392

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.775G>A; p.G259S; 14:60646363-60646363

 breastcarcinomaSubstitution - Missense

c.280G>T; p.E94*; 14:60648910-60648910

 breastcarcinomaSubstitution - Nonsense

c.328C>A; p.R110R; 14:60648862-60648862

 breastcarcinomaSubstitution - coding silent

c.720C>T; p.H240H; 14:60646418-60646418

 breastcarcinomaSubstitution - coding silent

c.731C>T; p.S244L; 14:60646407-60646407

 breastcarcinomaSubstitution - Missense

c.571G>A; p.E191K; 14:60646567-60646567

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.571G>A; p.E191K; 14:60646567-60646567

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.571G>A; p.E191K; 14:60646567-60646567

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.191G>A; p.R64H; 14:60648999-60648999

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.413T>C; p.V138A; 14:60648777-60648777

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.198C>T; p.L66L; 14:60648992-60648992

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.245A>G; p.K82R; 14:60648945-60648945

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.263T>G; p.L88R; 14:60648927-60648927

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.91G>A; p.G31S; 14:60649099-60649099

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.110T>C; p.L37P; 14:60649080-60649080

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.652G>A; p.E218K; 14:60646486-60646486

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.315C>A; p.A105A; 14:60648875-60648875

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.404C>T; p.S135L; 14:60648786-60648786

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.404C>T; p.S135L; 14:60648786-60648786

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.404C>T; p.S135L; 14:60648786-60648786

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.191G>A; p.R64H; 14:60648999-60648999

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.178C>T; p.R60C; 14:60649012-60649012

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.775G>A; p.G259S; 14:60646363-60646363

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.92G>T; p.G31V; 14:60649098-60649098

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.92G>T; p.G31V; 14:60649098-60649098

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.356G>A; p.R119H; 14:60648834-60648834

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.86G>A; p.R29H; 14:60649104-60649104

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.160G>T; p.A54S; 14:60649030-60649030

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.71G>A; p.G24D; 14:60649119-60649119

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.313G>A; p.A105T; 14:60648877-60648877

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.696delT; p.L233fs*19; 14:60646442-60646442

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.417G>A; p.L139L; 14:60648773-60648773

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.554A>C; p.K185T; 14:60648636-60648636

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.334C>T; p.R112C; 14:60648856-60648856

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.545C>T; p.A182V; 14:60648645-60648645

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.666T>A; p.P222P; 14:60646472-60646472

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.429C>T; p.Y143Y; 14:60648761-60648761

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.28A>G; p.T10A; 14:60649162-60649162

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.123C>T; p.D41D; 14:60649067-60649067

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.603C>A; p.N201K; 14:60646535-60646535

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.560+2T>A; p.?; 14:60648628-60648628

 livercarcinoma; hepatocellular_carcinomaUnknown

c.328C>G; p.R110G; 14:60648862-60648862

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.421G>T; p.E141*; 14:60648769-60648769

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.242C>A; p.P81H; 14:60648948-60648948

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.769A>T; p.S257C; 14:60646369-60646369

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.37C>A; p.Q13K; 14:60649153-60649153

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.5C>A; p.S2*; 14:60649185-60649185

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.720C>T; p.H240H; 14:60646418-60646418

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.270G>A; p.A90A; 14:60648920-60648920

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.721G>T; p.A241S; 14:60646417-60646417

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.633G>T; p.P211P; 14:60646505-60646505

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.798G>T; p.Q266H; 14:60646340-60646340

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.609C>T; p.L203L; 14:60646529-60646529

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.66G>A; p.Q22Q; 14:60649124-60649124

 pancreascarcinomaSubstitution - coding silent

c.269C>T; p.A90V; 14:60648921-60648921

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.482C>G; p.T161S; 14:60648708-60648708

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.270G>A; p.A90A; 14:60648920-60648920

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.400A>G; p.K134E; 14:60648790-60648790

 skinmalignant_melanomaSubstitution - Missense

c.778C>T; p.L260L; 14:60646360-60646360

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.822C>T; p.P274P; 14:60646316-60646316

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.613C>T; p.P205S; 14:60646525-60646525

 skinmalignant_melanomaSubstitution - Missense

c.851C>T; p.S284F; 14:60646287-60646287

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.440C>G; p.P147R; 14:60648750-60648750

 skinmalignant_melanomaSubstitution - Missense

c.87C>T; p.R29R; 14:60649103-60649103

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.844T>G; p.L282V; 14:60646294-60646294

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.313G>A; p.A105T; 14:60648877-60648877

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.432G>A; p.A144A; 14:60648758-60648758

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.328C>T; p.R110W; 14:60648862-60648862

 urinary_tract; bladdercarcinomaSubstitution - Missense