Entrez Gene

Basic Information
Gene ID	595
Name	CCND1
Synonymous	cyclin D1;CCND1;cyclin D1
Definition	B-cell CLL/lymphoma 1\|B-cell lymphoma 1 protein\|BCL-1 oncogene\|G1/S-specific cyclin-D1\|PRAD1 oncogene
Position	11q13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.778C>T; p.R260C; 11:69651172-69651172	breast	carcinoma	Substitution - Missense
c.826_828delGAG; p.E280delE; 11:69651220-69651222	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.727T>C; p.C243R; 11:69651121-69651121	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.318C>T; p.C106C; 11:69643150-69643150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.865_873delGACGTGCGG; p.R291_V293delRDV; 11:69651259-69651267	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.869_870insGCG; p.R291_D292insR; 11:69651263-69651264	endometrium	carcinoma; endometrioid_carcinoma	Insertion - In frame
c.859C>T; p.P287S; 11:69651253-69651253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.859C>T; p.P287S; 11:69651253-69651253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.694T>C; p.F232L; 11:69648113-69648113	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.860C>A; p.P287H; 11:69651254-69651254	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.512C>T; p.A171V; 11:69643929-69643929	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.730C>A; p.L244I; 11:69651124-69651124	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.497C>A; p.S166Y; 11:69643914-69643914	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.718G>A; p.D240N; 11:69648137-69648137	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.857C>T; p.T286I; 11:69651251-69651251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.878T>G; p.V293G; 11:69651272-69651272	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.857C>T; p.T286I; 11:69651251-69651251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.857C>T; p.T286I; 11:69651251-69651251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.857C>T; p.T286I; 11:69651251-69651251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.823G>T; p.E275*; 11:69651217-69651217	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.405G>T; p.E135D; 11:69643237-69643237	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.131A>C; p.Y44S; 11:69641444-69641444	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.131A>C; p.Y44S; 11:69641444-69641444	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.139T>G; p.C47G; 11:69641452-69641452	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.193C>T; p.L65L; 11:69641506-69641506	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - coding silent
c.193C>T; p.L65L; 11:69641506-69641506	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - coding silent
c.141T>G; p.C47W; 11:69641454-69641454	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.37A>T; p.I13F; 11:69641350-69641350	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.125T>A; p.V42E; 11:69641438-69641438	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.121T>C; p.S41P; 11:69641434-69641434	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.140G>C; p.C47S; 11:69641453-69641453	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.53C>G; p.P18R; 11:69641366-69641366	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.121T>A; p.S41T; 11:69641434-69641434	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.107A>G; p.E36G; 11:69641420-69641420	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.17T>C; p.L6P; 11:69641330-69641330	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.17T>C; p.L6P; 11:69641330-69641330	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.106G>A; p.E36K; 11:69641419-69641419	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.106G>A; p.E36K; 11:69641419-69641419	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.106G>A; p.E36K; 11:69641419-69641419	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.160C>T; p.P54S; 11:69641473-69641473	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.124G>A; p.V42M; 11:69641437-69641437	haematopoietic_and_lymphoid_tissue; stomach	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.9C>G; p.H3Q; 11:69641322-69641322	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>G; p.Y44D; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>G; p.Y44D; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>G; p.Y44D; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>G; p.Y44D; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.143T>C; p.V48A; 11:69641456-69641456	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.136A>G; p.K46E; 11:69641449-69641449	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.136A>G; p.K46E; 11:69641449-69641449	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.125T>C; p.V42A; 11:69641438-69641438	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.125T>C; p.V42A; 11:69641438-69641438	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.137A>C; p.K46T; 11:69641450-69641450	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.132C>G; p.Y44*; 11:69641445-69641445	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.132C>G; p.Y44*; 11:69641445-69641445	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.52C>T; p.P18S; 11:69641365-69641365	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.718G>C; p.D240H; 11:69648137-69648137	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.29T>C; p.V10A; 11:69641342-69641342	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.463A>G; p.M155V; 11:69643880-69643880	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.124G>C; p.V42L; 11:69641437-69641437	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.869T>G; p.V290G; 11:69651263-69651263	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.139T>A; p.C47S; 11:69641452-69641452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.139T>A; p.C47S; 11:69641452-69641452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.139T>A; p.C47S; 11:69641452-69641452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.139T>C; p.C47R; 11:69641452-69641452	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.138A>C; p.K46N; 11:69641451-69641451	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.147G>A; p.Q49Q; 11:69641460-69641460	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - coding silent
c.131A>G; p.Y44C; 11:69641444-69641444	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.131A>G; p.Y44C; 11:69641444-69641444	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.131A>G; p.Y44C; 11:69641444-69641444	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>C; p.Y44H; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>C; p.Y44H; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.130T>C; p.Y44H; 11:69641443-69641443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.137A>G; p.K46R; 11:69641450-69641450	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.106G>C; p.E36Q; 11:69641419-69641419	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.157C>T; p.L53L; 11:69641470-69641470	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - coding silent
c.157C>T; p.L53L; 11:69641470-69641470	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - coding silent
c.541C>T; p.H181Y; 11:69643958-69643958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.399G>A; p.R133R; 11:69643231-69643231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.826_828delGAG; p.E280delE; 11:69651220-69651222	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.826_828delGAG; p.E280delE; 11:69651220-69651222	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.697C>T; p.L233F; 11:69648116-69648116	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.613G>T; p.A205S; 11:69648032-69648032	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.778C>T; p.R260C; 11:69651172-69651172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.693C>A; p.R231R; 11:69648112-69648112	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.833A>G; p.E278G; 11:69651227-69651227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>T; p.P199L; 11:69648015-69648015	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.817G>T; p.E273*; 11:69651211-69651211	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.559G>A; p.A187T; 11:69643976-69643976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.347C>T; p.T116I; 11:69643179-69643179	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.123G>A; p.S41S; 11:69641436-69641436	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.11A>C; p.Q4P; 11:69641324-69641324	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.809C>T; p.A270V; 11:69651203-69651203	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.484G>A; p.E162K; 11:69643901-69643901	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.513_514GG>TA; p.E172K; 11:69643930-69643931	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.226G>A; p.E76K; 11:69643058-69643058	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.615G>T; p.A205A; 11:69648034-69648034	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.564C>T; p.L188L; 11:69643981-69643981	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.74A>C; p.D25A; 11:69641387-69641387	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.860C>T; p.P287L; 11:69651254-69651254	NS	malignant_melanoma	Substitution - Missense
c.808G>A; p.A270T; 11:69651202-69651202	NS	malignant_melanoma	Substitution - Missense
c.498C>A; p.S166S; 11:69643915-69643915	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.169C>A; p.R57R; 11:69641482-69641482	ovary	other; neoplasm	Substitution - coding silent
c.261C>G; p.R87R; 11:69643093-69643093	skin	malignant_melanoma	Substitution - coding silent
c.106G>A; p.E36K; 11:69641419-69641419	skin	malignant_melanoma	Substitution - Missense
c.603C>T; p.S201S; 11:69648022-69648022	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.602_603CC>TT; p.S201F; 11:69648021-69648022	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.375C>A; p.C125*; 11:69643207-69643207	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Nonsense
c.811G>A; p.A271T; 11:69651205-69651205	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.138A>G; p.K46K; 11:69641451-69641451	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.723G>A; p.P241P; 11:69648142-69648142	thyroid	other; neoplasm	Substitution - coding silent
c.555C>A; p.F185L; 11:69643972-69643972	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.122C>T; p.S41L; 11:69641435-69641435	urinary_tract; bladder	carcinoma	Substitution - Missense
c.564C>T; p.L188L; 11:69643981-69643981	urinary_tract; bladder	carcinoma	Substitution - coding silent

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COSMIC confirmed somatic mutation [Top]

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