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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

5894

Name

RAF1

Synonymous

Raf-1 proto-oncogene, serine/threonine kinase;RAF1;Raf-1 proto-oncogene, serine/threonine kinase

Definition

C-Raf proto-oncogene, serine/threonine kinase|Oncogene RAF1|RAF proto-oncogene serine/threonine-protein kinase|proto-oncogene c-RAF|raf proto-oncogene serine/threonine protein kinase|v-raf-1 murine leukemia viral oncogene homolog 1

Position

3p25

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1189C>G; p.L397V; 3:12591712-12591712

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.782C>G; p.P261R; 3:12604188-12604188

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.1814C>T; p.S605F; 3:12584647-12584647

 breastcarcinomaSubstitution - Missense

c.677T>A; p.V226D; 3:12606204-12606204

 breastcarcinomaSubstitution - Missense

c.1060C>T; p.R354W; 3:12599739-12599739

 breastcarcinomaSubstitution - Missense

c.364A>G; p.I122V; 3:12609292-12609292

 breastcarcinomaSubstitution - Missense

c.1265A>G; p.Q422R; 3:12590903-12590903

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.217C>T; p.R73*; 3:12612053-12612053

 central_nervous_system; braingliomaSubstitution - Nonsense

c.1517C>T; p.T506I; 3:12585700-12585700

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1854G>A; p.R618R; 3:12584607-12584607

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1164G>A; p.Q388Q; 3:12591737-12591737

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1107C>T; p.H369H; 3:12599692-12599692

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.218G>A; p.R73Q; 3:12612052-12612052

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.952C>T; p.R318W; 3:12600190-12600190

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1126A>C; p.I376L; 3:12591775-12591775

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1609G>A; p.V537I; 3:12585181-12585181

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1609G>A; p.V537I; 3:12585181-12585181

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.643C>T; p.R215C; 3:12606238-12606238

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1255A>G; p.I419V; 3:12590913-12590913

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.55G>T; p.D19Y; 3:12618667-12618667

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.572G>T; p.R191I; 3:12608775-12608775

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1842G>A; p.P614P; 3:12584619-12584619

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.346A>T; p.T116S; 3:12609310-12609310

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.375A>G; p.E125E; 3:12609281-12609281

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.1432G>A; p.E478K; 3:12585785-12585785

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; Burkitt_lymphomaSubstitution - Missense

c.849T>C; p.S283S; 3:12600401-12600401

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1830A>G; p.Q610Q; 3:12584631-12584631

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1219C>G; p.L407V; 3:12590949-12590949

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.576A>G; p.Q192Q; 3:12608771-12608771

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1272C>T; p.C424C; 3:12590896-12590896

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.845G>A; p.R282Q; 3:12600405-12600405

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.407T>C; p.L136P; 3:12609249-12609249

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1108G>A; p.G370R; 3:12599691-12599691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.874G>A; p.A292T; 3:12600268-12600268

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.580T>G; p.L194V; 3:12608767-12608767

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.782C>G; p.P261R; 3:12604188-12604188

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1420A>T; p.I474L; 3:12585797-12585797

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.424-6T>C; p.?; 3:12608929-12608929

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.1109_1111delGAG; p.G370delG; 3:12591790-12591792

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.293T>C; p.V98A; 3:12611977-12611977

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1853G>A; p.R618Q; 3:12584608-12584608

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.991A>G; p.R331G; 3:12599808-12599808

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.491G>A; p.R164Q; 3:12608856-12608856

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1609G>A; p.V537I; 3:12585181-12585181

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1853G>T; p.R618L; 3:12584608-12584608

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.556G>A; p.D186N; 3:12608791-12608791

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.118C>T; p.R40C; 3:12618604-12618604

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1004A>G; p.Q335R; 3:12599795-12599795

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1004A>G; p.Q335R; 3:12599795-12599795

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1432G>A; p.E478K; 3:12585785-12585785

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.408C>T; p.L136L; 3:12609248-12609248

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1426C>T; p.L476F; 3:12585791-12585791

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.987A>C; p.K329N; 3:12600155-12600155

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1608C>T; p.I536I; 3:12585182-12585182

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1886C>T; p.A629V; 3:12584575-12584575

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.775T>C; p.S259P; 3:12604195-12604195

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1166C>T; p.A389V; 3:12591735-12591735

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1483C>T; p.R495C; 3:12585734-12585734

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.221A>G; p.N74S; 3:12612049-12612049

 livercarcinomaSubstitution - Missense

c.221A>G; p.N74S; 3:12612049-12612049

 livercarcinomaSubstitution - Missense

c.1830A>G; p.Q610Q; 3:12584631-12584631

 livercarcinomaSubstitution - coding silent

c.172A>G; p.I58V; 3:12618550-12618550

 livercarcinomaSubstitution - Missense

c.172A>G; p.I58V; 3:12618550-12618550

 livercarcinomaSubstitution - Missense

c.257T>C; p.L86P; 3:12612013-12612013

 livercarcinomaSubstitution - Missense

c.257T>C; p.L86P; 3:12612013-12612013

 livercarcinomaSubstitution - Missense

c.34A>T; p.S12C; 3:12618688-12618688

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.344A>G; p.N115S; 3:12609312-12609312

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.344A>G; p.N115S; 3:12609312-12609312

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1192C>A; p.R398S; 3:12591709-12591709

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1937C>T; p.P646L; 3:12584524-12584524

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.782C>G; p.P261R; 3:12604188-12604188

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.40G>A; p.G14S; 3:12618682-12618682

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1351C>T; p.Q451*; 3:12590817-12590817

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.355G>T; p.A119S; 3:12609301-12609301

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.428G>A; p.R143Q; 3:12608919-12608919

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.955G>T; p.A319S; 3:12600187-12600187

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>G; p.S257W; 3:12604200-12604200

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.776C>T; p.S259F; 3:12604194-12604194

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.258C>G; p.L86L; 3:12612012-12612012

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1005G>C; p.Q335H; 3:12599794-12599794

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.1005G>C; p.Q335H; 3:12599794-12599794

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.297C>A; p.F99L; 3:12611973-12611973

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.775T>G; p.S259A; 3:12604195-12604195

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.775T>G; p.S259A; 3:12604195-12604195

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1484G>A; p.R495H; 3:12585733-12585733

 pancreascarcinomaSubstitution - Missense

c.1484G>A; p.R495H; 3:12585733-12585733

 pancreascarcinomaSubstitution - Missense

c.1484G>A; p.R495H; 3:12585733-12585733

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1079T>C; p.F360S; 3:12599720-12599720

 pancreascarcinomaSubstitution - Missense

c.1272C>T; p.C424C; 3:12590896-12590896

 prostatecarcinomaSubstitution - coding silent

c.1254A>C; p.A418A; 3:12590914-12590914

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.643C>T; p.R215C; 3:12606238-12606238

 prostatecarcinomaSubstitution - Missense

c.1655A>G; p.N552S; 3:12585135-12585135

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.59C>T; p.A20V; 3:12618663-12618663

 skinmalignant_melanomaSubstitution - Missense

c.483T>A; p.N161K; 3:12608864-12608864

 skinmalignant_melanomaSubstitution - Missense

c.343A>C; p.N115H; 3:12609313-12609313

 skinmalignant_melanomaSubstitution - Missense

c.790C>T; p.H264Y; 3:12604180-12604180

 skinmalignant_melanomaSubstitution - Missense

c.50T>C; p.F17S; 3:12618672-12618672

 skinmalignant_melanomaSubstitution - Missense

c.111C>T; p.G37G; 3:12618611-12618611

 skinmalignant_melanomaSubstitution - coding silent

c.122G>C; p.R41P; 3:12618600-12618600

 skinmalignant_melanomaSubstitution - Missense

c.216G>T; p.V72V; 3:12612054-12612054

 skinmalignant_melanomaSubstitution - coding silent

c.843T>G; p.I281M; 3:12600407-12600407

 skinmalignant_melanomaSubstitution - Missense

c.1275G>A; p.E425E; 3:12590893-12590893

 skinmalignant_melanomaSubstitution - coding silent

c.1896G>A; p.E632E; 3:12584565-12584565

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.770C>T; p.S257L; 3:12604200-12604200

 skinmalignant_melanomaSubstitution - Missense

c.1927C>T; p.P643S; 3:12584534-12584534

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1432G>A; p.E478K; 3:12585785-12585785

 skinmalignant_melanomaSubstitution - Missense

c.860C>A; p.S287*; 3:12600390-12600390

 skinmalignant_melanomaSubstitution - Nonsense

c.1173G>T; p.R391S; 3:12591728-12591728

 skinmalignant_melanomaSubstitution - Missense

c.189G>A; p.P63P; 3:12618533-12618533

 skinmalignant_melanomaSubstitution - coding silent

c.775T>C; p.S259P; 3:12604195-12604195

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.1880G>A; p.R627Q; 3:12584581-12584581

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1484G>A; p.R495H; 3:12585733-12585733

 stomachcarcinomaSubstitution - Missense

c.1311G>C; p.E437D; 3:12590857-12590857

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1858G>A; p.A620T; 3:12584603-12584603

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.30G>A; p.T10T; 3:12618692-12618692

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.668G>T; p.R223M; 3:12606213-12606213

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.643C>T; p.R215C; 3:12606238-12606238

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1049T>C; p.M350T; 3:12599750-12599750

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1660C>T; p.R554*; 3:12585130-12585130

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.770C>T; p.S257L; 3:12604200-12604200

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257L; 3:12604200-12604200

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.788T>C; p.V263A; 3:12604182-12604182

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1193G>T; p.R398L; 3:12591708-12591708

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1239A>C; p.T413T; 3:12590929-12590929

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.798C>T; p.V266V; 3:12604172-12604172

 thyroidcarcinomaSubstitution - coding silent

c.1837C>G; p.L613V; 3:12584624-12584624

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1837C>G; p.L613V; 3:12584624-12584624

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.1837C>G; p.L613V; 3:12584624-12584624

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1837C>G; p.L613V; 3:12584624-12584624

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.30G>A; p.T10T; 3:12618692-12618692

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.776C>T; p.S259F; 3:12604194-12604194

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.257T>G; p.L86R; 3:12612013-12612013

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.978G>A; p.E326E; 3:12600164-12600164

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent