Entrez Gene

Basic Information
Gene ID	57332
Name	CBX8
Synonymous	chromobox homolog 8;CBX8;chromobox homolog 8
Definition	Pc class 3 homolog\|chromobox homolog 8 (Pc class homolog, Drosophila)\|chromobox protein homolog 8\|polycomb 3\|rectachrome 1
Position	17q25.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.950G>T; p.G317V; 17:79794855-79794855	breast	carcinoma	Substitution - Missense
c.986G>A; p.G329E; 17:79794819-79794819	breast	carcinoma	Substitution - Missense
c.1161G>T; p.E387D; 17:79794644-79794644	breast	carcinoma	Substitution - Missense
c.647G>A; p.G216D; 17:79795158-79795158	breast	carcinoma	Substitution - Missense
c.944G>A; p.S315N; 17:79794861-79794861	breast	carcinoma	Substitution - Missense
c.1081G>C; p.V361L; 17:79794724-79794724	breast	carcinoma	Substitution - Missense
c.146T>C; p.L49P; 17:79796283-79796283	breast	carcinoma	Substitution - Missense
c.913A>C; p.T305P; 17:79794892-79794892	breast	carcinoma	Substitution - Missense
c.329C>T; p.S110L; 17:79795476-79795476	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.539G>A; p.R180Q; 17:79795266-79795266	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.696C>T; p.D232D; 17:79795109-79795109	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.661G>A; p.G221S; 17:79795144-79795144	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.209A>G; p.K70R; 17:79796094-79796094	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520C>T; p.R174C; 17:79795285-79795285	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.119G>T; p.S40I; 17:79796310-79796310	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.901G>T; p.D301Y; 17:79794904-79794904	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.942delC; p.S315fs*41; 17:79794863-79794863	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.942delC; p.S315fs*41; 17:79794863-79794863	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.953G>A; p.G318E; 17:79794852-79794852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.950G>T; p.G317V; 17:79794855-79794855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.950G>T; p.G317V; 17:79794855-79794855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1166G>T; p.R389I; 17:79794639-79794639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.60C>T; p.R20R; 17:79796939-79796939	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1155delT; p.F385fs*>5; 17:79794650-79794650	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1155delT; p.F385fs*>5; 17:79794650-79794650	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1155delT; p.F385fs*>5; 17:79794650-79794650	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.162C>T; p.L54L; 17:79796267-79796267	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.218G>T; p.G73V; 17:79796085-79796085	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1077G>A; p.E359E; 17:79794728-79794728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.S190S; 17:79795235-79795235	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.874C>A; p.L292M; 17:79794931-79794931	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>T; p.R72C; 17:79796089-79796089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.699C>T; p.D233D; 17:79795106-79795106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.611G>A; p.R204Q; 17:79795194-79795194	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.949G>A; p.G317R; 17:79794856-79794856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.398C>T; p.A133V; 17:79795407-79795407	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>A; p.A56T; 17:79796263-79796263	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.956_957insG; p.L320fs*38; 17:79794848-79794849	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.956_957insG; p.L320fs*38; 17:79794848-79794849	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.202G>T; p.G68C; 17:79796101-79796101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.956_957insG; p.L320fs*38; 17:79794848-79794849	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.965G>A; p.R322Q; 17:79794840-79794840	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.942_943insC; p.S315fs*43; 17:79794862-79794863	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.657C>T; p.S219S; 17:79795148-79795148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.956delG; p.G319fs*37; 17:79794849-79794849	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.956delG; p.G319fs*37; 17:79794849-79794849	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.956delG; p.G319fs*37; 17:79794849-79794849	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.215G>A; p.R72H; 17:79796088-79796088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.950G>T; p.G317V; 17:79794855-79794855	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.486A>C; p.R162R; 17:79795319-79795319	liver	carcinoma	Substitution - coding silent
c.486A>C; p.R162R; 17:79795319-79795319	liver	carcinoma	Substitution - coding silent
c.431C>T; p.A144V; 17:79795374-79795374	liver	carcinoma	Substitution - Missense
c.431C>T; p.A144V; 17:79795374-79795374	liver	carcinoma	Substitution - Missense
c.964C>G; p.R322G; 17:79794841-79794841	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.980A>G; p.Q327R; 17:79794825-79794825	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.899T>C; p.L300P; 17:79794906-79794906	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1092G>C; p.T364T; 17:79794713-79794713	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.761A>G; p.Q254R; 17:79795044-79795044	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.878A>C; p.E293A; 17:79794927-79794927	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.111G>A; p.Q37Q; 17:79796499-79796499	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1055G>C; p.S352T; 17:79794750-79794750	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.877G>T; p.E293*; 17:79794928-79794928	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.463G>C; p.D155H; 17:79795342-79795342	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.85C>G; p.L29V; 17:79796525-79796525	ovary	other; neoplasm	Substitution - Missense
c.796C>T; p.P266S; 17:79795009-79795009	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.843G>A; p.P281P; 17:79794962-79794962	pancreas	carcinoma	Substitution - coding silent
c.768G>A; p.S256S; 17:79795037-79795037	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.383G>A; p.G128D; 17:79795422-79795422	skin; trunk	malignant_melanoma	Substitution - Missense
c.1100C>T; p.T367I; 17:79794705-79794705	skin	malignant_melanoma	Substitution - Missense
c.1027C>T; p.L343L; 17:79794778-79794778	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.995C>T; p.S332F; 17:79794810-79794810	skin	malignant_melanoma	Substitution - Missense
c.625G>A; p.D209N; 17:79795180-79795180	skin	malignant_melanoma	Substitution - Missense
c.144C>T; p.I48I; 17:79796285-79796285	skin	malignant_melanoma	Substitution - coding silent
c.574C>T; p.P192S; 17:79795231-79795231	skin	malignant_melanoma	Substitution - Missense
c.502C>T; p.R168*; 17:79795303-79795303	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.319C>T; p.P107S; 17:79795486-79795486	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.370C>T; p.L124F; 17:79795435-79795435	skin	malignant_melanoma	Substitution - Missense
c.382G>A; p.G128S; 17:79795423-79795423	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.774G>T; p.L258L; 17:79795031-79795031	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.860A>T; p.H287L; 17:79794945-79794945	skin	malignant_melanoma	Substitution - Missense
c.996C>A; p.S332S; 17:79794809-79794809	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.904C>T; p.P302S; 17:79794901-79794901	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.36G>A; p.A12A; 17:79796963-79796963	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.T372T; 17:79794689-79794689	skin	malignant_melanoma	Substitution - coding silent
c.240C>T; p.L80L; 17:79796063-79796063	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.215G>A; p.R72H; 17:79796088-79796088	skin	malignant_melanoma	Substitution - Missense
c.106T>C; p.S36P; 17:79796504-79796504	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.295G>C; p.A99P; 17:79795510-79795510	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>T; p.R72C; 17:79796089-79796089	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>C; p.E58Q; 17:79796257-79796257	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1143_1156del14; p.D381fs*>5; 17:79794649-79794662	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.956delG; p.G319fs*37; 17:79794849-79794849	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.950G>T; p.G317V; 17:79794855-79794855	thyroid	other; neoplasm	Substitution - Missense
c.553G>A; p.V185M; 17:79795252-79795252	thyroid	other; neoplasm	Substitution - Missense
c.916C>T; p.R306W; 17:79794889-79794889	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.164C>T; p.A55V; 17:79796265-79796265	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1144C>T; p.Q382*; 17:79794661-79794661	urinary_tract; bladder	carcinoma	Substitution - Nonsense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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