Entrez Gene

Basic Information
Gene ID	5584
Name	PRKCI
Synonymous	protein kinase C, iota;PRKCI;protein kinase C, iota
Definition	PRKC-lambda/iota\|aPKC-lambda/iota\|atypical protein kinase C-lambda/iota\|protein kinase C iota type
Position	3q26.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.880G>T; p.E294*; 3:170280401-170280401	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.963C>T; p.C321C; 3:170281246-170281246	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1048C>T; p.L350F; 3:170281949-170281949	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1540G>C; p.A514P; 3:170297346-170297346	breast	carcinoma	Substitution - Missense
c.361G>C; p.D121H; 3:170263426-170263426	breast	carcinoma	Substitution - Missense
c.736T>G; p.S246A; 3:170280257-170280257	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.335G>A; p.R112H; 3:170263400-170263400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.608T>C; p.M203T; 3:170273302-170273302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1631C>A; p.S544Y; 3:170299038-170299038	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.545G>A; p.C182Y; 3:170270515-170270515	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1377C>T; p.S459S; 3:170293468-170293468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.660T>G; p.N220K; 3:170275242-170275242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1560G>C; p.P520P; 3:170297366-170297366	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1647G>T; p.L549F; 3:170299054-170299054	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1230C>G; p.T410T; 3:170291880-170291880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1568G>A; p.R523Q; 3:170297374-170297374	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.334C>T; p.R112C; 3:170263399-170263399	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.894G>T; p.W298C; 3:170281177-170281177	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.23G>A; p.S8N; 3:170222692-170222692	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1153T>C; p.L385L; 3:170284546-170284546	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1049T>G; p.L350R; 3:170281950-170281950	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1288T>C; p.Y430H; 3:170291938-170291938	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>T; p.L185L; 3:170270525-170270525	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1290T>C; p.Y430Y; 3:170291940-170291940	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1440C>T; p.R480R; 3:170295933-170295933	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1211T>C; p.L404S; 3:170291861-170291861	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.335G>A; p.R112H; 3:170263400-170263400	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>T; p.P118L; 3:170263418-170263418	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>A; p.P118Q; 3:170263418-170263418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1215G>A; p.R405R; 3:170291865-170291865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.433G>A; p.A145T; 3:170267983-170267983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.819delA; p.T276fs*7; 3:170280340-170280340	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.819delA; p.T276fs*7; 3:170280340-170280340	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.819delA; p.T276fs*7; 3:170280340-170280340	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.819delA; p.T276fs*7; 3:170280340-170280340	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.819delA; p.T276fs*7; 3:170280340-170280340	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.795T>A; p.Y265*; 3:170280316-170280316	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.354A>G; p.P118P; 3:170263419-170263419	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.354A>G; p.P118P; 3:170263419-170263419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.354A>G; p.P118P; 3:170263419-170263419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.354A>G; p.P118P; 3:170263419-170263419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.418G>T; p.G140C; 3:170267968-170267968	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1736T>G; p.F579C; 3:170303072-170303072	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1289A>G; p.Y430C; 3:170291939-170291939	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1439G>T; p.R480L; 3:170295932-170295932	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.61G>T; p.D21Y; 3:170222730-170222730	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.706-1G>T; p.?; 3:170280226-170280226	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.108C>T; p.I36I; 3:170235236-170235236	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.108C>T; p.I36I; 3:170235236-170235236	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1192G>A; p.G398S; 3:170284585-170284585	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.862G>T; p.E288*; 3:170280383-170280383	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1213C>T; p.R405W; 3:170291863-170291863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.815G>C; p.R272P; 3:170280336-170280336	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.815G>C; p.R272P; 3:170280336-170280336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.574C>T; p.R192W; 3:170270544-170270544	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698A>G; p.E233G; 3:170275280-170275280	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1375T>C; p.S459P; 3:170293466-170293466	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.832C>T; p.R278C; 3:170280353-170280353	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.818_819insA; p.T276fs*16; 3:170280339-170280340	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.818_819insA; p.T276fs*16; 3:170280339-170280340	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.818_819insA; p.T276fs*16; 3:170280339-170280340	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1448G>A; p.R483H; 3:170295941-170295941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1439G>A; p.R480H; 3:170295932-170295932	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1439G>A; p.R480H; 3:170295932-170295932	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1439G>A; p.R480H; 3:170295932-170295932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1100A>G; p.N367S; 3:170284493-170284493	liver	carcinoma	Substitution - Missense
c.1100A>G; p.N367S; 3:170284493-170284493	liver	carcinoma	Substitution - Missense
c.976A>G; p.S326G; 3:170281259-170281259	liver	carcinoma	Substitution - Missense
c.976A>G; p.S326G; 3:170281259-170281259	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1203+3G>T; p.?; 3:170284599-170284599	liver	carcinoma	Unknown
c.1203+3G>T; p.?; 3:170284599-170284599	liver	carcinoma	Unknown
c.1390C>A; p.Q464K; 3:170293481-170293481	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1400A>G; p.E467G; 3:170293491-170293491	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1387G>C; p.D463H; 3:170293478-170293478	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1387G>C; p.D463H; 3:170293478-170293478	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1675G>C; p.E559Q; 3:170299082-170299082	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.895G>A; p.V299I; 3:170281178-170281178	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.948T>A; p.V316V; 3:170281231-170281231	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.801A>T; p.K267N; 3:170280322-170280322	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1457C>A; p.S486Y; 3:170295950-170295950	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1289A>G; p.Y430C; 3:170291939-170291939	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.846G>C; p.M282I; 3:170280367-170280367	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1119G>A; p.G373G; 3:170284512-170284512	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1188C>A; p.D396E; 3:170284581-170284581	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.382G>T; p.G128C; 3:170267932-170267932	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1703+2T>G; p.?; 3:170299112-170299112	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1279G>A; p.G427R; 3:170291929-170291929	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.111G>T; p.M37I; 3:170235239-170235239	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1642G>T; p.G548C; 3:170299049-170299049	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.556G>A; p.V186I; 3:170270526-170270526	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1269A>T; p.E423D; 3:170291919-170291919	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1307G>T; p.W436L; 3:170293398-170293398	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.223G>T; p.G75*; 3:170235351-170235351	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1438C>A; p.R480S; 3:170295931-170295931	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1292G>T; p.G431V; 3:170293383-170293383	ovary	other; neoplasm	Substitution - Missense
c.1292G>T; p.G431V; 3:170293383-170293383	ovary	other; neoplasm	Substitution - Missense
c.1008T>G; p.N336K; 3:170281909-170281909	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1438C>T; p.R480C; 3:170295931-170295931	pancreas	carcinoma	Substitution - Missense
c.1586T>G; p.M529R; 3:170297392-170297392	pancreas	carcinoma	Substitution - Missense
c.573G>A; p.G191G; 3:170270543-170270543	prostate	carcinoma	Substitution - coding silent
c.826_827insAA; p.T276fs*8; 3:170280347-170280348	prostate	carcinoma	Insertion - Frameshift
c.1511G>A; p.R504Q; 3:170297317-170297317	prostate	carcinoma	Substitution - Missense
c.1188C>G; p.D396E; 3:170284581-170284581	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.959C>T; p.S320F; 3:170281242-170281242	skin	malignant_melanoma	Substitution - Missense
c.229C>T; p.P77S; 3:170259974-170259974	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1726C>T; p.Q576*; 3:170303062-170303062	skin; extremity	malignant_melanoma	Substitution - Nonsense
c.1267G>A; p.E423K; 3:170291917-170291917	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.831T>C; p.D277D; 3:170280352-170280352	skin	malignant_melanoma	Substitution - coding silent
c.353C>T; p.P118L; 3:170263418-170263418	skin	malignant_melanoma	Substitution - Missense
c.353C>T; p.P118L; 3:170263418-170263418	skin	malignant_melanoma	Substitution - Missense
c.196T>A; p.F66I; 3:170235324-170235324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.242C>T; p.S81L; 3:170259987-170259987	skin	malignant_melanoma	Substitution - Missense
c.535C>T; p.H179Y; 3:170270505-170270505	skin	malignant_melanoma	Substitution - Missense
c.781G>A; p.G261R; 3:170280302-170280302	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1759C>T; p.P587S; 3:170303095-170303095	skin	malignant_melanoma	Substitution - Missense
c.943C>T; p.L315F; 3:170281226-170281226	skin	malignant_melanoma	Substitution - Missense
c.943C>T; p.L315F; 3:170281226-170281226	skin	malignant_melanoma	Substitution - Missense
c.1209A>G; p.G403G; 3:170291859-170291859	skin	malignant_melanoma	Substitution - coding silent
c.1012G>A; p.G338R; 3:170281913-170281913	skin	malignant_melanoma	Substitution - Missense
c.148C>T; p.L50F; 3:170235276-170235276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.78C>T; p.V26V; 3:170222747-170222747	skin	malignant_melanoma	Substitution - coding silent
c.581C>T; p.S194F; 3:170270551-170270551	skin	malignant_melanoma	Substitution - Missense
c.1418T>A; p.V473D; 3:170295911-170295911	skin	malignant_melanoma	Substitution - Missense
c.141T>C; p.F47F; 3:170235269-170235269	skin	malignant_melanoma	Substitution - coding silent
c.148C>A; p.L50I; 3:170235276-170235276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1008T>C; p.N336N; 3:170281909-170281909	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.819delA; p.T276fs*7; 3:170280340-170280340	stomach	adenocarcinoma	Deletion - Frameshift
c.478C>T; p.R160*; 3:170270448-170270448	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Nonsense
c.574C>T; p.R192W; 3:170270544-170270544	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.832C>T; p.R278C; 3:170280353-170280353	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1442T>A; p.I481K; 3:170295935-170295935	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>A; p.R480S; 3:170295931-170295931	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.976A>G; p.S326G; 3:170281259-170281259	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1522C>A; p.H508N; 3:170297328-170297328	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.581C>T; p.S194F; 3:170270551-170270551	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.581C>T; p.S194F; 3:170270551-170270551	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.581C>T; p.S194F; 3:170270551-170270551	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1076C>G; p.S359C; 3:170284469-170284469	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1772C>G; p.S591C; 3:170303108-170303108	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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