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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

5578

Name

PRKCA

Synonymous

protein kinase C, alpha;PRKCA;protein kinase C, alpha

Definition

PKC-A|aging-associated gene 6|protein kinase C alpha type

Position

17q22-q23.2

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1971G>A; p.S657S; 17:66803989-66803989

 breastcarcinomaSubstitution - coding silent

c.532C>T; p.R178*; 17:66687113-66687113

 breastcarcinomaSubstitution - Nonsense

c.1331C>T; p.A444V; 17:66741667-66741667

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.1140C>T; p.D380D; 17:66735572-66735572

 breastcarcinomaSubstitution - coding silent

c.1087G>A; p.E363K; 17:66735519-66735519

 breastcarcinomaSubstitution - Missense

c.815G>A; p.S272N; 17:66688430-66688430

 breastcarcinoma; HER-positive_carcinomaSubstitution - Missense

c.1127T>A; p.I376N; 17:66735559-66735559

 breastcarcinomaSubstitution - Missense

c.1837C>T; p.P613S; 17:66788962-66788962

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1399G>A; p.D467N; 17:66742635-66742635

 central_nervous_system; braingliomaSubstitution - Missense

c.1399G>A; p.D467N; 17:66742635-66742635

 central_nervous_system; braingliomaSubstitution - Missense

c.1399G>A; p.D467N; 17:66742635-66742635

 central_nervous_system; braingliomaSubstitution - Missense

c.1399G>A; p.D467N; 17:66742635-66742635

 central_nervous_system; braingliomaSubstitution - Missense

c.1516G>A; p.A506T; 17:66742752-66742752

 central_nervous_system; braingliomaSubstitution - Missense

c.1779G>A; p.E593E; 17:66788904-66788904

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1779G>A; p.E593E; 17:66788904-66788904

 central_nervous_system; braingliomaSubstitution - coding silent

c.1264G>A; p.G422S; 17:66738797-66738797

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.65G>A; p.R22H; 17:66302916-66302916

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1756G>C; p.E586Q; 17:66788881-66788881

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.280G>A; p.D94N; 17:66496275-66496275

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1540delC; p.P514fs*59; 17:66774002-66774002

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.645C>T; p.I215I; 17:66687226-66687226

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.547C>A; p.L183I; 17:66687128-66687128

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1970C>T; p.S657L; 17:66803988-66803988

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.513A>C; p.E171D; 17:66645495-66645495

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1166G>A; p.R389Q; 17:66735598-66735598

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1304T>G; p.F435C; 17:66738837-66738837

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.915C>T; p.F305F; 17:66689044-66689044

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.915C>T; p.F305F; 17:66689044-66689044

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1854G>A; p.V618V; 17:66788979-66788979

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1508A>G; p.D503G; 17:66742744-66742744

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1331C>T; p.A444V; 17:66741667-66741667

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1164G>A; p.K388K; 17:66735596-66735596

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1554T>C; p.S518S; 17:66774016-66774016

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.857A>G; p.Y286C; 17:66688986-66688986

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.160A>C; p.T54P; 17:66303011-66303011

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.810G>A; p.P270P; 17:66688425-66688425

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.1996C>T; p.P666S; 17:66804014-66804014

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.565A>T; p.N189Y; 17:66687146-66687146

 kidneyother; neoplasmSubstitution - Missense

c.1149C>T; p.C383C; 17:66735581-66735581

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1923T>C; p.D641D; 17:66803941-66803941

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1251G>A; p.M417I; 17:66738784-66738784

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1895G>A; p.R632Q; 17:66803913-66803913

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1023C>T; p.F341F; 17:66732792-66732792

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1011G>A; p.T337T; 17:66732780-66732780

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.294C>A; p.P98P; 17:66641360-66641360

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.405C>T; p.C135C; 17:66645387-66645387

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1733C>T; p.A578V; 17:66788858-66788858

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2013A>G; p.A671A; 17:66804031-66804031

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.294C>T; p.P98P; 17:66641360-66641360

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.294C>T; p.P98P; 17:66641360-66641360

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1141G>A; p.V381M; 17:66735573-66735573

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1779G>A; p.E593E; 17:66788904-66788904

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.292C>T; p.P98S; 17:66641358-66641358

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.292C>T; p.P98S; 17:66641358-66641358

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.346G>A; p.D116N; 17:66641412-66641412

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1600G>A; p.G534R; 17:66774062-66774062

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1600G>A; p.G534R; 17:66774062-66774062

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1458G>T; p.K486N; 17:66742694-66742694

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1973A>G; p.Y658C; 17:66803991-66803991

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1973A>G; p.Y658C; 17:66803991-66803991

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.362T>C; p.L121P; 17:66641428-66641428

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.691T>C; p.L231L; 17:66688306-66688306

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1406T>C; p.V469A; 17:66742642-66742642

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1406T>C; p.V469A; 17:66742642-66742642

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.516G>A; p.K172K; 17:66645498-66645498

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.49G>A; p.A17T; 17:66302900-66302900

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.291delC; p.R99fs*32; 17:66641357-66641357

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1245C>T; p.F415F; 17:66738778-66738778

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1443C>A; p.D481E; 17:66742679-66742679

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.75G>A; p.A25A; 17:66302926-66302926

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1741C>T; p.L581L; 17:66788866-66788866

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.831G>A; p.L277L; 17:66688960-66688960

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1770C>T; p.D590D; 17:66788895-66788895

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1515C>T; p.I505I; 17:66742751-66742751

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.254C>A; p.S85Y; 17:66496249-66496249

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1332G>A; p.A444A; 17:66741668-66741668

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1792C>T; p.R598W; 17:66788917-66788917

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.293C>T; p.P98L; 17:66641359-66641359

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1101C>A; p.I367I; 17:66735533-66735533

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1012G>T; p.D338Y; 17:66732781-66732781

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.225C>A; p.H75Q; 17:66496220-66496220

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.887A>T; p.E296V; 17:66689016-66689016

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.397G>A; p.D133N; 17:66641463-66641463

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.770G>T; p.G257V; 17:66688385-66688385

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1922A>G; p.D641G; 17:66803940-66803940

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.120C>A; p.I40I; 17:66302971-66302971

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1875C>A; p.N625K; 17:66803893-66803893

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.463C>T; p.H155Y; 17:66645445-66645445

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.699T>C; p.P233P; 17:66688314-66688314

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1404C>G; p.N468K; 17:66742640-66742640

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.507T>C; p.A169A; 17:66645489-66645489

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.97G>A; p.E33K; 17:66302948-66302948

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.137A>C; p.Q46P; 17:66302988-66302988

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1082C>A; p.T361K; 17:66735514-66735514

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1796_1797GG>TT; p.R599I; 17:66788921-66788922

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.32C>T; p.T11M; 17:66302883-66302883

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1567G>T; p.A523S; 17:66774029-66774029

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1576G>A; p.V526I; 17:66774038-66774038

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1053A>G; p.G351G; 17:66732822-66732822

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1068C>T; p.A356A; 17:66735500-66735500

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.178T>C; p.F60L; 17:66306100-66306100

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1825G>C; p.E609Q; 17:66788950-66788950

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.266C>T; p.A89V; 17:66496261-66496261

 ovaryother; neoplasmSubstitution - Missense

c.482G>A; p.R161Q; 17:66645464-66645464

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1894C>T; p.R632*; 17:66803912-66803912

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.1896A>C; p.R632R; 17:66803914-66803914

 ovaryother; neoplasmSubstitution - coding silent

c.1016T>A; p.F339Y; 17:66732785-66732785

 ovarycarcinomaSubstitution - Missense

c.1620T>G; p.G540G; 17:66786881-66786881

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1691A>G; p.E564G; 17:66786952-66786952

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1691A>G; p.E564G; 17:66786952-66786952

 pancreascarcinomaSubstitution - Missense

c.1405G>A; p.V469I; 17:66742641-66742641

 pancreascarcinomaSubstitution - Missense

c.1405G>A; p.V469I; 17:66742641-66742641

 pancreascarcinomaSubstitution - Missense

c.1405G>A; p.V469I; 17:66742641-66742641

 pancreascarcinomaSubstitution - Missense

c.1459G>A; p.E487K; 17:66742695-66742695

 pancreasother; adenomaSubstitution - Missense

c.481C>T; p.R161W; 17:66645463-66645463

 pancreascarcinomaSubstitution - Missense

c.1405G>A; p.V469I; 17:66742641-66742641

 prostateadenomaSubstitution - Missense

c.618T>A; p.N206K; 17:66687199-66687199

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1215C>T; p.S405S; 17:66735647-66735647

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.520C>T; p.H174Y; 17:66645502-66645502

 skinmalignant_melanomaSubstitution - Missense

c.254C>T; p.S85F; 17:66496249-66496249

 skinmalignant_melanomaSubstitution - Missense

c.1482G>A; p.T494T; 17:66742718-66742718

 skinmalignant_melanomaSubstitution - coding silent

c.1360C>T; p.L454F; 17:66741696-66741696

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.880G>A; p.D294N; 17:66689009-66689009

 skinmalignant_melanomaSubstitution - Missense

c.1273C>T; p.L425F; 17:66738806-66738806

 skinmalignant_melanomaSubstitution - Missense

c.1855-6C>T; p.?; 17:66803867-66803867

 skin; armmalignant_melanomaUnknown

c.1679_1680CC>TT; p.S560F; 17:66786940-66786941

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1864G>A; p.G622R; 17:66803882-66803882

 skinmalignant_melanomaSubstitution - Missense

c.552_553CC>TT; p.P185S; 17:66687133-66687134

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.196C>T; p.Q66*; 17:66306118-66306118

 skinmalignant_melanomaSubstitution - Nonsense

c.196C>T; p.Q66*; 17:66306118-66306118

 skinmalignant_melanomaSubstitution - Nonsense

c.958C>T; p.P320S; 17:66732727-66732727

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1679C>T; p.S560F; 17:66786940-66786940

 skinmalignant_melanomaSubstitution - Missense

c.1245C>T; p.F415F; 17:66738778-66738778

 skinmalignant_melanomaSubstitution - coding silent

c.1816G>A; p.E606K; 17:66788941-66788941

 skinmalignant_melanomaSubstitution - Missense

c.205+1G>A; p.?; 17:66306128-66306128

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.60C>T; p.F20F; 17:66302911-66302911

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.529+1G>T; p.?; 17:66645512-66645512

 skinmalignant_melanomaUnknown

c.558G>A; p.M186I; 17:66687139-66687139

 skinmalignant_melanomaSubstitution - Missense

c.1230+3A>G; p.?; 17:66735665-66735665

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.454G>A; p.G152R; 17:66645436-66645436

 skinmalignant_melanomaSubstitution - Missense

c.779C>T; p.S260F; 17:66688394-66688394

 skinmalignant_melanomaSubstitution - Missense

c.1012G>A; p.D338N; 17:66732781-66732781

 skinmalignant_melanomaSubstitution - Missense

c.1012G>A; p.D338N; 17:66732781-66732781

 skinmalignant_melanomaSubstitution - Missense

c.1517C>T; p.A506V; 17:66742753-66742753

 skinmalignant_melanomaSubstitution - Missense

c.1983C>T; p.P661P; 17:66804001-66804001

 skinmalignant_melanomaSubstitution - coding silent

c.1586A>G; p.Y529C; 17:66774048-66774048

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.328G>A; p.G110R; 17:66641394-66641394

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.955A>G; p.S319G; 17:66732724-66732724

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.540delA; p.N182fs*2; 17:66687121-66687121

 stomachcarcinoma; adenocarcinomaDeletion - Frameshift

c.540delA; p.N182fs*2; 17:66687121-66687121

 stomachcarcinoma; adenocarcinomaDeletion - Frameshift

c.540delA; p.N182fs*2; 17:66687121-66687121

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.540delA; p.N182fs*2; 17:66687121-66687121

 stomachadenocarcinomaDeletion - Frameshift

c.454G>A; p.G152R; 17:66645436-66645436

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1575C>T; p.G525G; 17:66774037-66774037

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.647G>A; p.R216H; 17:66687228-66687228

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1203G>A; p.T401T; 17:66735635-66735635

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.831G>A; p.L277L; 17:66688960-66688960

 thyroidother; neoplasmSubstitution - coding silent

c.839_841delAAG; p.E282delE; 17:66688968-66688970

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.1574G>A; p.G525D; 17:66774036-66774036

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1769A>G; p.D590G; 17:66788894-66788894

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.173G>T; p.W58L; 17:66303024-66303024

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1289A>G; p.Q430R; 17:66738822-66738822

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.316A>T; p.I106F; 17:66641382-66641382

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.60C>T; p.F20F; 17:66302911-66302911

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.36G>A; p.A12A; 17:66302887-66302887

 urinary_tract; bladdercarcinomaSubstitution - coding silent