Entrez Gene

Basic Information
Gene ID	5468
Name	PPARG
Synonymous	peroxisome proliferator-activated receptor gamma;PPARG;peroxisome proliferator-activated receptor gamma
Definition	PPAR-gamma\|nuclear receptor subfamily 1 group C member 3\|peroxisome proliferator-activated nuclear receptor gamma variant 1
Position	3p25
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.290T>G; p.L97R; 3:12379911-12379911	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.724C>G; p.L242V; 3:12405986-12405986	breast	carcinoma	Substitution - Missense
c.724C>G; p.L242V; 3:12405986-12405986	breast	carcinoma	Substitution - Missense
c.235G>A; p.E79K; 3:12379856-12379856	breast	carcinoma	Substitution - Missense
c.922C>T; p.R308C; 3:12416806-12416806	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1230C>T; p.S410S; 3:12417114-12417114	central_nervous_system; brain	glioma	Substitution - coding silent
c.668C>T; p.A223V; 3:12405930-12405930	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.668C>T; p.A223V; 3:12405930-12405930	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.262C>G; p.P88A; 3:12379883-12379883	central_nervous_system; brain	glioma	Substitution - Missense
c.1295A>C; p.K432T; 3:12433922-12433922	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.669G>A; p.A223A; 3:12405931-12405931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.789G>A; p.A263A; 3:12406051-12406051	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1054G>A; p.E352K; 3:12416938-12416938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.37G>T; p.E13*; 3:12351629-12351629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.922C>T; p.R308C; 3:12416806-12416806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.109C>T; p.P37S; 3:12379730-12379730	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.532C>A; p.L178I; 3:12392665-12392665	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.682G>T; p.D228Y; 3:12405944-12405944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.169T>A; p.S57T; 3:12379790-12379790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1431C>T; p.H477H; 3:12434058-12434058	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1431C>T; p.H477H; 3:12434058-12434058	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.746C>T; p.S249L; 3:12406008-12406008	kidney	other; neoplasm	Substitution - Missense
c.491G>A; p.R164Q; 3:12392624-12392624	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.11C>G; p.T4S; 3:12351603-12351603	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.327G>A; p.E109E; 3:12381338-12381338	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.168C>G; p.H56Q; 3:12379789-12379789	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.637A>G; p.M213V; 3:12405899-12405899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.550delA; p.S186fs*47; 3:12392683-12392683	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.550delA; p.S186fs*47; 3:12392683-12392683	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.75A>T; p.I25I; 3:12351667-12351667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1348A>C; p.K450Q; 3:12433975-12433975	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1348A>C; p.K450Q; 3:12433975-12433975	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1348A>C; p.K450Q; 3:12433975-12433975	large_intestine; colon	carcinoma	Substitution - Missense
c.1348A>C; p.K450Q; 3:12433975-12433975	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1094A>G; p.D365G; 3:12416978-12416978	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.556A>G; p.S186G; 3:12392689-12392689	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.303G>A; p.E101E; 3:12379924-12379924	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.887delC; p.L298fs*38; 3:12416771-12416771	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.887delC; p.L298fs*38; 3:12416771-12416771	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1477C>T; p.L493F; 3:12434104-12434104	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1105A>T; p.I369L; 3:12416989-12416989	liver	carcinoma	Substitution - Missense
c.1105A>T; p.I369L; 3:12416989-12416989	liver	carcinoma	Substitution - Missense
c.686T>C; p.I229T; 3:12405948-12405948	liver	carcinoma	Substitution - Missense
c.686T>C; p.I229T; 3:12405948-12405948	liver	carcinoma	Substitution - Missense
c.553A>G; p.K185E; 3:12392686-12392686	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1452C>A; p.I484I; 3:12434079-12434079	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1248T>A; p.I416I; 3:12417132-12417132	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.765G>T; p.P255P; 3:12406027-12406027	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1067C>A; p.T356K; 3:12416951-12416951	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.882C>T; p.H294H; 3:12416766-12416766	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.7G>A; p.E3K; 3:12351599-12351599	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>A; p.E488K; 3:12434089-12434089	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.480+7delA; p.?; 3:12381498-12381498	NS	malignant_melanoma	Unknown
c.1095T>C; p.D365D; 3:12416979-12416979	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1515C>G; p.Y505*; 3:12434142-12434142	ovary	other; neoplasm	Substitution - Nonsense
c.1515C>G; p.Y505*; 3:12434142-12434142	ovary	other; neoplasm	Substitution - Nonsense
c.1515C>G; p.Y505*; 3:12434142-12434142	ovary	other; neoplasm	Substitution - Nonsense
c.1515C>G; p.Y505*; 3:12434142-12434142	ovary	other; neoplasm	Substitution - Nonsense
c.1481A>C; p.H494P; 3:12434108-12434108	pancreas	carcinoma	Substitution - Missense
c.1402A>G; p.T468A; 3:12434029-12434029	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.254G>A; p.R85K; 3:12379875-12379875	skin	malignant_melanoma	Substitution - Missense
c.703G>A; p.E235K; 3:12405965-12405965	skin	malignant_melanoma	Substitution - Missense
c.946C>T; p.R316C; 3:12416830-12416830	skin	malignant_melanoma	Substitution - Missense
c.669G>A; p.A223A; 3:12405931-12405931	skin	malignant_melanoma	Substitution - coding silent
c.3G>A; p.M1I; 3:12351595-12351595	skin	malignant_melanoma	Substitution - Missense
c.1114G>A; p.G372S; 3:12416998-12416998	skin	malignant_melanoma	Substitution - Missense
c.3G>A; p.M1I; 3:12351595-12351595	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1114G>A; p.G372S; 3:12416998-12416998	skin	malignant_melanoma	Substitution - Missense
c.1104C>T; p.L368L; 3:12416988-12416988	skin	malignant_melanoma	Substitution - coding silent
c.845C>T; p.S282F; 3:12416729-12416729	skin	malignant_melanoma	Substitution - Missense
c.845C>T; p.S282F; 3:12416729-12416729	skin	malignant_melanoma	Substitution - Missense
c.179T>G; p.F60C; 3:12379800-12379800	skin	malignant_melanoma	Substitution - Missense
c.448C>T; p.H150Y; 3:12381459-12381459	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.998G>A; p.G333D; 3:12416882-12416882	skin	malignant_melanoma	Substitution - Missense
c.1484C>G; p.P495R; 3:12434111-12434111	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.605G>A; p.G202E; 3:12392738-12392738	skin	malignant_melanoma	Substitution - Missense
c.657G>A; p.E219E; 3:12405919-12405919	skin	malignant_melanoma	Substitution - coding silent
c.186C>T; p.I62I; 3:12379807-12379807	skin	malignant_melanoma	Substitution - coding silent
c.641C>T; p.P214L; 3:12405903-12405903	skin	malignant_melanoma	Substitution - Missense
c.1059C>T; p.I353I; 3:12416943-12416943	skin	malignant_melanoma	Substitution - coding silent
c.77C>T; p.S26L; 3:12351669-12351669	skin	malignant_melanoma	Substitution - Missense
c.109C>T; p.P37S; 3:12379730-12379730	skin	malignant_melanoma	Substitution - Missense
c.398_399CC>TT; p.S133F; 3:12381409-12381410	skin	malignant_melanoma	Substitution - Missense
c.298C>T; p.Q100*; 3:12379919-12379919	skin	malignant_melanoma	Substitution - Nonsense
c.399C>T; p.S133S; 3:12381410-12381410	skin	malignant_melanoma	Substitution - coding silent
c.668C>T; p.A223V; 3:12405930-12405930	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.176C>T; p.S59F; 3:12379797-12379797	skin; mucosal	malignant_melanoma	Substitution - Missense
c.455G>A; p.G152E; 3:12381466-12381466	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1270+1G>A; p.?; 3:12417155-12417155	skin	malignant_melanoma	Unknown
c.1154G>A; p.R385Q; 3:12417038-12417038	skin	malignant_melanoma	Substitution - Missense
c.672G>A; p.E224E; 3:12405934-12405934	skin	malignant_melanoma	Substitution - coding silent
c.1190A>G; p.E397G; 3:12417074-12417074	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1460C>T; p.T487M; 3:12434087-12434087	stomach	adenocarcinoma	Substitution - Missense
c.556A>G; p.S186G; 3:12392689-12392689	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.556A>G; p.S186G; 3:12392689-12392689	stomach	adenocarcinoma	Substitution - Missense
c.177C>A; p.S59S; 3:12379798-12379798	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1413A>G; p.R471R; 3:12434040-12434040	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.419G>A; p.R140H; 3:12381430-12381430	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.783G>C; p.A261A; 3:12406045-12406045	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1480C>T; p.H494Y; 3:12434107-12434107	urinary_tract; bladder	carcinoma	Substitution - Missense
c.648C>A; p.A216A; 3:12405910-12405910	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.870C>G; p.I290M; 3:12416754-12416754	urinary_tract; bladder	carcinoma	Substitution - Missense
c.940C>G; p.Q314E; 3:12416824-12416824	urinary_tract; bladder	carcinoma	Substitution - Missense
c.940C>G; p.Q314E; 3:12416824-12416824	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.7G>A; p.E3K; 3:12351599-12351599	urinary_tract; bladder	carcinoma	Substitution - Missense
c.7G>A; p.E3K; 3:12351599-12351599	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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