Entrez Gene

Basic Information
Gene ID	5347
Name	PLK1
Synonymous	polo-like kinase 1;PLK1;polo-like kinase 1
Definition	PLK-1\|cell cycle regulated protein kinase\|polo (Drosophia)-like kinase\|polo like kinase\|serine/threonine-protein kinase 13\|serine/threonine-protein kinase PLK1
Position	16p12.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.478A>T; p.I160F; 16:23680153-23680153	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1593G>T; p.Q531H; 16:23689661-23689661	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1110C>T; p.V370V; 16:23687542-23687542	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1773G>A; p.L591L; 16:23690024-23690024	breast	carcinoma	Substitution - coding silent
c.732G>C; p.L244F; 16:23682073-23682073	breast	carcinoma	Substitution - Missense
c.324C>G; p.L108L; 16:23679256-23679256	breast	carcinoma	Substitution - coding silent
c.658C>G; p.P220A; 16:23680994-23680994	breast	carcinoma	Substitution - Missense
c.833C>G; p.A278G; 16:23683886-23683886	central_nervous_system; brain	glioma	Substitution - Missense
c.749C>A; p.P250H; 16:23682090-23682090	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1022C>T; p.T341I; 16:23684075-23684075	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.690C>T; p.F230F; 16:23681026-23681026	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1515C>T; p.L505L; 16:23689583-23689583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.910T>G; p.F304V; 16:23683963-23683963	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1558G>A; p.A520T; 16:23689626-23689626	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.664G>T; p.V222L; 16:23681000-23681000	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.690C>A; p.F230L; 16:23681026-23681026	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1683A>C; p.T561T; 16:23689934-23689934	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.169C>A; p.R57S; 16:23679101-23679101	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1586G>A; p.S529N; 16:23689654-23689654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.938G>A; p.R313H; 16:23683991-23683991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.556G>T; p.E186*; 16:23680231-23680231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1687C>T; p.R563C; 16:23689938-23689938	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1070delA; p.E359fs*96; 16:23687502-23687502	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1748C>T; p.A583V; 16:23689999-23689999	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1499G>A; p.R500H; 16:23689567-23689567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.146G>A; p.S49N; 16:23679078-23679078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.506G>A; p.R169Q; 16:23680181-23680181	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1100G>T; p.G367V; 16:23687532-23687532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1605delC; p.Q536fs*11; 16:23689673-23689673	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.977C>T; p.S326L; 16:23684030-23684030	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.47A>G; p.D16G; 16:23678979-23678979	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.690C>T; p.F230F; 16:23681026-23681026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.690C>T; p.F230F; 16:23681026-23681026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1264G>C; p.G422R; 16:23688739-23688739	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.690C>A; p.F230L; 16:23681026-23681026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.660C>T; p.P220P; 16:23680996-23680996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1751G>A; p.R584H; 16:23690002-23690002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1318A>G; p.T440A; 16:23689285-23689285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1003A>C; p.S335R; 16:23684056-23684056	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.955C>A; p.L319M; 16:23684008-23684008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1382C>T; p.S461F; 16:23689349-23689349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1090C>T; p.R364*; 16:23687522-23687522	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1090C>T; p.R364*; 16:23687522-23687522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1736G>A; p.R579Q; 16:23689987-23689987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.874G>A; p.A292T; 16:23683927-23683927	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1419_1421delGAA; p.K475delK; 16:23689386-23689388	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.451C>T; p.P151S; 16:23680126-23680126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698A>G; p.D233G; 16:23681034-23681034	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1757_1759delTGG; p.V587delV; 16:23690008-23690010	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.409-1G>T; p.?; 16:23680083-23680083	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.845T>G; p.I282S; 16:23683898-23683898	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.505C>T; p.R169*; 16:23680180-23680180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.596C>T; p.T199I; 16:23680932-23680932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>T; p.T199I; 16:23680932-23680932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.P250S; 16:23682089-23682089	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.L141L; 16:23680096-23680096	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1688G>A; p.R563H; 16:23689939-23689939	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1803G>T; p.K601N; 16:23690054-23690054	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1803G>T; p.K601N; 16:23690054-23690054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1803G>T; p.K601N; 16:23690054-23690054	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1458G>A; p.M486I; 16:23689526-23689526	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1242G>A; p.W414*; 16:23688717-23688717	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1123A>G; p.S375G; 16:23687555-23687555	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>T; p.G238W; 16:23681048-23681048	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>T; p.G238W; 16:23681048-23681048	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.329A>G; p.H110R; 16:23679261-23679261	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1525C>T; p.P509S; 16:23689593-23689593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1010G>A; p.R337Q; 16:23684063-23684063	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.219G>A; p.A73A; 16:23679151-23679151	liver	carcinoma	Substitution - coding silent
c.219G>A; p.A73A; 16:23679151-23679151	liver	carcinoma	Substitution - coding silent
c.463T>C; p.Y155H; 16:23680138-23680138	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.463T>C; p.Y155H; 16:23680138-23680138	liver	carcinoma	Substitution - Missense
c.938G>A; p.R313H; 16:23683991-23683991	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1792A>T; p.N598Y; 16:23690043-23690043	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.878G>A; p.R293H; 16:23683931-23683931	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1041G>C; p.L347F; 16:23687473-23687473	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.143G>A; p.R48H; 16:23679075-23679075	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.452C>T; p.P151L; 16:23680127-23680127	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1003A>T; p.S335C; 16:23684056-23684056	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1551C>T; p.T517T; 16:23689619-23689619	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1784C>T; p.S595L; 16:23690035-23690035	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.738_739insT; p.G247fs*6; 16:23682079-23682080	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.863C>A; p.T288K; 16:23683916-23683916	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.461G>T; p.R154L; 16:23680136-23680136	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.35G>T; p.R12L; 16:23678967-23678967	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.35G>T; p.R12L; 16:23678967-23678967	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.907G>T; p.E303*; 16:23683960-23683960	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.892G>A; p.E298K; 16:23683945-23683945	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.375C>G; p.F125L; 16:23679307-23679307	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1410C>T; p.N470N; 16:23689377-23689377	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1343G>T; p.G448V; 16:23689310-23689310	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.785G>A; p.R262Q; 16:23682126-23682126	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1467C>G; p.H489Q; 16:23689535-23689535	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1469T>G; p.L490W; 16:23689537-23689537	pancreas	carcinoma	Substitution - Missense
c.1531C>A; p.L511I; 16:23689599-23689599	pancreas	carcinoma	Substitution - Missense
c.937C>A; p.R313S; 16:23683990-23683990	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.614G>T; p.G205V; 16:23680950-23680950	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1446C>T; p.F482F; 16:23689514-23689514	skin	malignant_melanoma	Substitution - coding silent
c.968C>T; p.P323L; 16:23684021-23684021	skin	malignant_melanoma	Substitution - Missense
c.977C>T; p.S326L; 16:23684030-23684030	skin	malignant_melanoma	Substitution - Missense
c.977C>T; p.S326L; 16:23684030-23684030	skin	malignant_melanoma	Substitution - Missense
c.1412_1413CC>TT; p.S471F; 16:23689379-23689380	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1573C>T; p.L525F; 16:23689641-23689641	skin	malignant_melanoma	Substitution - Missense
c.1176T>G; p.R392R; 16:23687608-23687608	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1617C>A; p.T539T; 16:23689868-23689868	skin	malignant_melanoma	Substitution - coding silent
c.1167C>T; p.P389P; 16:23687599-23687599	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1308C>T; p.F436F; 16:23689275-23689275	skin	malignant_melanoma	Substitution - coding silent
c.1434C>T; p.L478L; 16:23689502-23689502	skin; arm	malignant_melanoma	Substitution - coding silent
c.1525C>T; p.P509S; 16:23689593-23689593	skin	malignant_melanoma	Substitution - Missense
c.913T>A; p.F305I; 16:23683966-23683966	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.913T>A; p.F305I; 16:23683966-23683966	stomach	adenocarcinoma	Substitution - Missense
c.1499G>A; p.R500H; 16:23689567-23689567	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.906C>T; p.D302D; 16:23683959-23683959	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1745A>G; p.Y582C; 16:23689996-23689996	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1009C>T; p.R337W; 16:23684062-23684062	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.833C>A; p.A278D; 16:23683886-23683886	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.209T>A; p.I70N; 16:23679141-23679141	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.505C>T; p.R169*; 16:23680180-23680180	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1598A>G; p.N533S; 16:23689666-23689666	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.210C>T; p.I70I; 16:23679142-23679142	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1296delG; p.V434fs*21; 16:23689263-23689263	stomach	adenocarcinoma	Deletion - Frameshift
c.1721A>C; p.K574T; 16:23689972-23689972	thyroid	other; neoplasm	Substitution - Missense
c.1567C>T; p.L523L; 16:23689635-23689635	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.468_469insT; p.L157fs*30; 16:23680143-23680144	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.418G>C; p.E140Q; 16:23680093-23680093	urinary_tract; bladder	carcinoma	Substitution - Missense
c.418G>C; p.E140Q; 16:23680093-23680093	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.531C>T; p.L177L; 16:23680206-23680206	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.531C>T; p.L177L; 16:23680206-23680206	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.3G>A; p.M1I; 16:23678935-23678935	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1575C>T; p.L525L; 16:23689643-23689643	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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