Entrez Gene

Basic Information
Gene ID	5155
Name	PDGFB
Synonymous	platelet-derived growth factor beta polypeptide;PDGFB;platelet-derived growth factor beta polypeptide
Definition	PDGF subunit B\|PDGF, B chain\|becaplermin\|platelet-derived growth factor 2\|platelet-derived growth factor B chain\|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)\|platelet-derived growth factor subunit B\|plate
Position	22q13.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.529delG; p.A177fs*13; 22:39230156-39230156	breast	carcinoma	Deletion - Frameshift
c.646C>T; p.R216C; 22:39225803-39225803	breast	carcinoma	Substitution - Missense
c.657C>A; p.P219P; 22:39225792-39225792	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.687G>A; p.T229T; 22:39225762-39225762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.623T>C; p.V208A; 22:39225826-39225826	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.608C>T; p.T203M; 22:39225841-39225841	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.671G>A; p.R224Q; 22:39225778-39225778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.599G>A; p.R200Q; 22:39230086-39230086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.507G>A; p.T169T; 22:39230178-39230178	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.35G>T; p.C12F; 22:39243929-39243929	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.280A>C; p.I94L; 22:39231798-39231798	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.306G>T; p.E102D; 22:39231772-39231772	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.633G>T; p.R211R; 22:39225816-39225816	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.37T>C; p.C13R; 22:39243927-39243927	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.672G>T; p.R224R; 22:39225777-39225777	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.478C>T; p.R160W; 22:39230207-39230207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.296C>T; p.T99M; 22:39231782-39231782	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.458T>G; p.V153G; 22:39230227-39230227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698C>T; p.T233M; 22:39225751-39225751	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.622G>A; p.V208M; 22:39225827-39225827	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.613C>A; p.Q205K; 22:39225836-39225836	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.8G>T; p.R3L; 22:39243956-39243956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.644T>C; p.V215A; 22:39225805-39225805	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.644T>C; p.V215A; 22:39225805-39225805	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.644T>C; p.V215A; 22:39225805-39225805	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.137G>A; p.R46H; 22:39235801-39235801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.657C>T; p.P219P; 22:39225792-39225792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.335A>T; p.D112V; 22:39231743-39231743	large_intestine; colon	carcinoma	Substitution - Missense
c.335A>T; p.D112V; 22:39231743-39231743	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.184C>T; p.L62L; 22:39233501-39233501	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.670C>T; p.R224W; 22:39225779-39225779	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.111G>T; p.S37S; 22:39235827-39235827	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.79G>T; p.E27*; 22:39235859-39235859	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.649C>T; p.R217W; 22:39225800-39225800	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.598C>T; p.R200*; 22:39230087-39230087	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.544A>G; p.T182A; 22:39230141-39230141	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.599G>A; p.R200Q; 22:39230086-39230086	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>A; p.I106I; 22:39231760-39231760	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.478C>T; p.R160W; 22:39230207-39230207	pancreas	carcinoma	Substitution - Missense
c.468C>T; p.I156I; 22:39230217-39230217	pancreas	carcinoma	Substitution - coding silent
c.579G>A; p.P193P; 22:39230106-39230106	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.354C>T; p.F118F; 22:39231724-39231724	skin	malignant_melanoma	Substitution - coding silent
c.354C>T; p.F118F; 22:39231724-39231724	skin	malignant_melanoma	Substitution - coding silent
c.279G>A; p.M93I; 22:39231799-39231799	skin	malignant_melanoma	Substitution - Missense
c.175G>A; p.E59K; 22:39233510-39233510	skin	malignant_melanoma	Substitution - Missense
c.660G>A; p.K220K; 22:39225789-39225789	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.457-1G>A; p.?; 22:39230229-39230229	skin	malignant_melanoma	Unknown
c.254C>T; p.S85F; 22:39231824-39231824	skin	malignant_melanoma	Substitution - Missense
c.672G>A; p.R224R; 22:39225777-39225777	skin	malignant_melanoma	Substitution - coding silent
c.572G>A; p.R191Q; 22:39230113-39230113	skin	malignant_melanoma	Substitution - Missense
c.148G>A; p.G50R; 22:39235790-39235790	skin	malignant_melanoma	Substitution - Missense
c.661G>A; p.G221S; 22:39225788-39225788	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.162G>A; p.E54E; 22:39233523-39233523	skin	malignant_melanoma	Substitution - coding silent
c.312C>T; p.F104F; 22:39231766-39231766	skin	malignant_melanoma	Substitution - coding silent
c.468C>T; p.I156I; 22:39230217-39230217	skin	malignant_melanoma	Substitution - coding silent
c.560G>A; p.R187Q; 22:39230125-39230125	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.687G>A; p.T229T; 22:39225762-39225762	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.656C>A; p.P219H; 22:39225793-39225793	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.157G>A; p.G53R; 22:39235781-39235781	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.E59K; 22:39233510-39233510	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.116G>A; p.R39H; 22:39235822-39235822	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.345C>T; p.N115N; 22:39231733-39231733	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.686C>T; p.T229M; 22:39225763-39225763	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.282C>T; p.I94I; 22:39231796-39231796	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.609G>A; p.T203T; 22:39225840-39225840	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.584delG; p.G195fs*14; 22:39230101-39230101	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.29C>T; p.S10F; 22:39243935-39243935	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.386G>A; p.R129H; 22:39231692-39231692	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.299G>A; p.R100H; 22:39231779-39231779	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.206C>G; p.S69C; 22:39233479-39233479	urinary_tract; bladder	carcinoma	Substitution - Missense
c.33C>T; p.L11L; 22:39243931-39243931	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.468C>T; p.I156I; 22:39230217-39230217	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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