ONGene
Top
Scroll To Top
Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

51548

Name

SIRT6

Synonymous

sirtuin 6;SIRT6;sirtuin 6

Definition

NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6|sir2-related protein type 6|sirtuin type 6

Position

19p13.3

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.15C>T; p.Y5Y; 19:4182525-4182525

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.964C>T; p.Q322*; 19:4174721-4174721

 breastcarcinomaSubstitution - Nonsense

c.137G>A; p.S46N; 19:4180839-4180839

 breastcarcinomaSubstitution - Missense

c.404delA; p.N135fs*25; 19:4177112-4177112

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaDeletion - Frameshift

c.107A>T; p.E36V; 19:4180869-4180869

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.590T>C; p.L197P; 19:4175704-4175704

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.23G>A; p.G8E; 19:4182517-4182517

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.741C>T; p.D247D; 19:4174944-4174944

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.956C>T; p.P319L; 19:4174729-4174729

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.483C>T; p.A161A; 19:4175892-4175892

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.924C>G; p.N308K; 19:4174761-4174761

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.757C>T; p.R253C; 19:4174928-4174928

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.937G>T; p.A313S; 19:4174748-4174748

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.712A>G; p.I238V; 19:4175054-4175054

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1059C>T; p.V353V; 19:4174626-4174626

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1059C>T; p.V353V; 19:4174626-4174626

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.246C>A; p.F82L; 19:4179235-4179235

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.362G>T; p.R121L; 19:4179119-4179119

 livercarcinomaSubstitution - Missense

c.778G>T; p.E260*; 19:4174907-4174907

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.265G>T; p.A89S; 19:4179216-4179216

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.243G>T; p.K81N; 19:4179238-4179238

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.346G>A; p.D116N; 19:4179135-4179135

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.73G>A; p.D25N; 19:4180903-4180903

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.365C>G; p.S122*; 19:4179116-4179116

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.789C>T; p.T263T; 19:4174896-4174896

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1002G>A; p.E334E; 19:4174683-4174683

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.194+7G>A; p.?; 19:4180775-4180775

 pancreascarcinomaUnknown

c.80C>G; p.P27R; 19:4180896-4180896

 salivary_glandcarcinoma; adenoid_cystic_carcinomaSubstitution - Missense

c.870C>T; p.P290P; 19:4174815-4174815

 skinmalignant_melanomaSubstitution - coding silent

c.23G>A; p.G8E; 19:4182517-4182517

 skinmalignant_melanomaSubstitution - Missense

c.23G>A; p.G8E; 19:4182517-4182517

 skinmalignant_melanomaSubstitution - Missense

c.23G>A; p.G8E; 19:4182517-4182517

 skinmalignant_melanomaSubstitution - Missense

c.72C>T; p.F24F; 19:4180904-4180904

 skinmalignant_melanomaSubstitution - coding silent

c.79C>T; p.P27S; 19:4180897-4180897

 skinmalignant_melanomaSubstitution - Missense

c.703C>T; p.R235C; 19:4175063-4175063

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.205G>A; p.G69R; 19:4179276-4179276

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.242A>G; p.K81R; 19:4179239-4179239

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.311T>A; p.V104E; 19:4179170-4179170

 thyroidother; neoplasmSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.671A>C; p.N224T; 19:4175095-4175095

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.752A>C; p.D251A; 19:4174933-4174933

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.367G>T; p.G123C; 19:4179114-4179114

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.367G>T; p.G123C; 19:4179114-4179114

 urinary_tract; bladdercarcinomaSubstitution - Missense