Entrez Gene

Basic Information
Gene ID	51176
Name	LEF1
Synonymous	lymphoid enhancer-binding factor 1;LEF1;lymphoid enhancer-binding factor 1
Definition	T cell-specific transcription factor 1-alpha\|TCF1-alpha
Position	4q23-q25
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.952G>T; p.V318F; 4:108078276-108078276	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.846-7_846-6insACC; p.?; 4:108078388-108078389	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.111C>A; p.I37I; 4:108167657-108167657	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.182C>G; p.S61C; 4:108167586-108167586	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.391_392delCT; p.L131fs*10; 4:108163590-108163591	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.972A>T; p.K324N; 4:108078256-108078256	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.640C>T; p.Q214*; 4:108081668-108081668	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.933A>C; p.K311N; 4:108078295-108078295	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.745G>A; p.G249S; 4:108079592-108079592	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.120G>T; p.E40D; 4:108167648-108167648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.658C>G; p.P220A; 4:108081650-108081650	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.319T>C; p.S107P; 4:108163663-108163663	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.396T>C; p.S132S; 4:108163586-108163586	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - coding silent
c.560A>C; p.H187P; 4:108083434-108083434	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.363T>G; p.N121K; 4:108163619-108163619	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.318C>T; p.P106P; 4:108163664-108163664	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.915T>C; p.A305A; 4:108078313-108078313	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.269A>C; p.H90P; 4:108165108-108165108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.400C>T; p.P134S; 4:108163582-108163582	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.215T>C; p.V72A; 4:108165162-108165162	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.252C>T; p.H84H; 4:108165125-108165125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.925T>C; p.Y309H; 4:108078303-108078303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.914C>T; p.A305V; 4:108078314-108078314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.362A>G; p.N121S; 4:108163620-108163620	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.886delA; p.R296fs*8; 4:108078342-108078342	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.788T>C; p.I263T; 4:108079549-108079549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.916T>C; p.F306L; 4:108078312-108078312	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.745G>A; p.G249S; 4:108079592-108079592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1195A>C; p.I399L; 4:108063634-108063634	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.40delG; p.D14fs*10; 4:108167728-108167728	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1057C>T; p.R353W; 4:108070722-108070722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.337G>A; p.G113R; 4:108163645-108163645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898A>G; p.K300E; 4:108078330-108078330	liver	carcinoma	Substitution - Missense
c.898A>G; p.K300E; 4:108078330-108078330	liver	carcinoma	Substitution - Missense
c.722+7G>C; p.?; 4:108081579-108081579	liver	carcinoma	Unknown
c.280G>T; p.G94*; 4:108165097-108165097	liver	carcinoma	Substitution - Nonsense
c.280G>T; p.G94*; 4:108165097-108165097	liver	carcinoma	Substitution - Nonsense
c.1016C>A; p.A339D; 4:108070763-108070763	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.318C>A; p.P106P; 4:108163664-108163664	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.410G>A; p.R137K; 4:108163572-108163572	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>A; p.P44H; 4:108167637-108167637	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.413C>G; p.T138R; 4:108163569-108163569	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.284A>G; p.K95R; 4:108163698-108163698	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1025G>T; p.R342L; 4:108070754-108070754	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.826G>C; p.D276H; 4:108079511-108079511	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.722+1G>T; p.?; 4:108081585-108081585	lung	carcinoma; adenocarcinoma	Unknown
c.834C>G; p.D278E; 4:108079503-108079503	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>T; p.V72L; 4:108165163-108165163	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.157A>G; p.I53V; 4:108167611-108167611	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.157A>G; p.I53V; 4:108167611-108167611	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.243G>C; p.E81D; 4:108165134-108165134	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.715A>G; p.M239V; 4:108081593-108081593	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.589delT; p.Y197fs*50; 4:108083405-108083405	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.31G>A; p.G11S; 4:108167737-108167737	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.628C>G; p.P210A; 4:108083366-108083366	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1094G>T; p.G365V; 4:108070685-108070685	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.723-3C>G; p.?; 4:108079617-108079617	lung	carcinoma; small_cell_carcinoma	Unknown
c.208C>G; p.H70D; 4:108167560-108167560	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.611T>G; p.V204G; 4:108083383-108083383	meninges	meningioma	Substitution - Missense
c.78C>A; p.F26L; 4:108167690-108167690	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.327G>A; p.S109S; 4:108163655-108163655	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.280+1G>T; p.?; 4:108165096-108165096	ovary	carcinoma; serous_carcinoma	Unknown
c.1057C>T; p.R353W; 4:108070722-108070722	pancreas	carcinoma	Substitution - Missense
c.1057C>T; p.R353W; 4:108070722-108070722	pancreas	carcinoma	Substitution - Missense
c.326C>A; p.S109*; 4:108163656-108163656	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.424G>A; p.V142M; 4:108089248-108089248	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.998T>C; p.L333P; 4:108078230-108078230	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.281G>A; p.G94E; 4:108163701-108163701	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1A>G; p.M1V; 4:108167767-108167767	skin	malignant_melanoma	Substitution - Missense
c.739A>T; p.I247F; 4:108079598-108079598	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.406C>T; p.P136S; 4:108163576-108163576	skin	malignant_melanoma	Substitution - Missense
c.592C>T; p.P198S; 4:108083402-108083402	skin	malignant_melanoma	Substitution - Missense
c.592C>T; p.P198S; 4:108083402-108083402	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274G>A; p.D92N; 4:108165103-108165103	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.580C>T; p.P194S; 4:108083414-108083414	skin	malignant_melanoma	Substitution - Missense
c.36G>C; p.G12G; 4:108167732-108167732	stomach	adenocarcinoma	Substitution - coding silent
c.127C>T; p.H43Y; 4:108167641-108167641	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.401C>T; p.P134L; 4:108163581-108163581	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1121A>C; p.K374T; 4:108064380-108064380	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.821A>G; p.H274R; 4:108079516-108079516	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.452T>C; p.V151A; 4:108089220-108089220	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.933A>T; p.K311N; 4:108078295-108078295	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1047T>C; p.Y349Y; 4:108070732-108070732	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.856C>T; p.H286Y; 4:108078372-108078372	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.449C>T; p.A150V; 4:108089223-108089223	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.621C>T; p.I207I; 4:108083373-108083373	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.905C>T; p.P302L; 4:108078323-108078323	urinary_tract; bladder	carcinoma	Substitution - Missense
c.353C>G; p.P118R; 4:108163629-108163629	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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