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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

5058

Name

PAK1

Synonymous

p21 protein (Cdc42/Rac)-activated kinase 1;PAK1;p21 protein (Cdc42/Rac)-activated kinase 1

Definition

STE20 homolog, yeast|alpha-PAK|p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)|p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)|p65-PAK|serine/threonine-protein kinase PAK 1

Position

11q13-q14

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1111C>T; p.R371C; 11:77340651-77340651

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.910C>T; p.Q304*; 11:77343907-77343907

 breastcarcinomaSubstitution - Nonsense

c.184G>A; p.D62N; 11:77392337-77392337

 breastcarcinomaSubstitution - Missense

c.1114G>A; p.E372K; 11:77340648-77340648

 breastcarcinomaSubstitution - Missense

c.531G>T; p.E177D; 11:77358964-77358964

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.772C>T; p.R258*; 11:77355668-77355668

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.976A>C; p.N326H; 11:77343841-77343841

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.790G>T; p.G264C; 11:77353582-77353582

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.190+1G>A; p.?; 11:77392330-77392330

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1526G>A; p.R509K; 11:77332755-77332755

 haematopoietic_and_lymphoid_tissue; soft_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.1447G>A; p.E483K; 11:77332834-77332834

 haematopoietic_and_lymphoid_tissue; soft_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.1071A>C; p.T357T; 11:77340691-77340691

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1581C>G; p.L527L; 11:77323331-77323331

 kidneycarcinoma; renal_cell_carcinomaSubstitution - coding silent

c.1581C>G; p.L527L; 11:77323331-77323331

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.685A>G; p.T229A; 11:77355755-77355755

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1333G>T; p.V445F; 11:77336166-77336166

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1333G>T; p.V445F; 11:77336166-77336166

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.477+2T>C; p.?; 11:77374326-77374326

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.414C>T; p.N138N; 11:77379266-77379266

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.356A>G; p.K119R; 11:77379324-77379324

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.772C>T; p.R258*; 11:77355668-77355668

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1262G>T; p.R421L; 11:77336237-77336237

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.951G>A; p.L317L; 11:77343866-77343866

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.951G>A; p.L317L; 11:77343866-77343866

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.80G>A; p.G27D; 11:77392441-77392441

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.949C>A; p.L317M; 11:77343868-77343868

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.95G>A; p.G32E; 11:77392426-77392426

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.935T>G; p.I312S; 11:77343882-77343882

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.935T>G; p.I312S; 11:77343882-77343882

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.935T>G; p.I312S; 11:77343882-77343882

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1262G>A; p.R421Q; 11:77336237-77336237

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.167G>A; p.R56Q; 11:77392354-77392354

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.331A>C; p.N111H; 11:77379349-77379349

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.607C>T; p.R203W; 11:77355833-77355833

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.950T>C; p.L317P; 11:77343867-77343867

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.120T>G; p.P40P; 11:77392401-77392401

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.120T>G; p.P40P; 11:77392401-77392401

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.792C>T; p.G264G; 11:77353580-77353580

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.299C>T; p.P100L; 11:77379381-77379381

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1230C>A; p.F410L; 11:77336269-77336269

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.950T>A; p.L317Q; 11:77343867-77343867

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.89A>G; p.D30G; 11:77392432-77392432

 livercarcinomaSubstitution - Missense

c.789G>A; p.V263V; 11:77353583-77353583

 livercarcinomaSubstitution - coding silent

c.789G>A; p.V263V; 11:77353583-77353583

 livercarcinomaSubstitution - coding silent

c.196A>G; p.K66E; 11:77379989-77379989

 livercarcinomaSubstitution - Missense

c.485A>G; p.K162R; 11:77359010-77359010

 livercarcinomaSubstitution - Missense

c.253A>G; p.I85V; 11:77379932-77379932

 livercarcinomaSubstitution - Missense

c.1371G>A; p.M457I; 11:77336128-77336128

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1112G>T; p.R371L; 11:77340650-77340650

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.285G>T; p.E95D; 11:77379900-77379900

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.399G>A; p.S133S; 11:77379281-77379281

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.223A>T; p.I75F; 11:77379962-77379962

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1507G>A; p.E503K; 11:77332774-77332774

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1000T>G; p.Y334D; 11:77340762-77340762

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.789G>T; p.V263V; 11:77353583-77353583

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1431C>A; p.A477A; 11:77332850-77332850

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.928G>T; p.E310*; 11:77343889-77343889

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1066G>T; p.V356L; 11:77340696-77340696

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1557A>G; p.Q519Q; 11:77323355-77323355

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1024G>T; p.V342F; 11:77340738-77340738

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.354G>A; p.K118K; 11:77379326-77379326

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.398C>T; p.S133L; 11:77379282-77379282

 NSmalignant_melanomaSubstitution - Missense

c.313C>T; p.R105C; 11:77379367-77379367

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1181A>G; p.N394S; 11:77337359-77337359

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.451G>A; p.E151K; 11:77374354-77374354

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1311A>T; p.T437T; 11:77336188-77336188

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.772+1G>T; p.?; 11:77355667-77355667

 ovarycarcinoma; serous_carcinomaUnknown

c.1419G>C; p.L473F; 11:77332862-77332862

 ovaryother; neoplasmSubstitution - Missense

c.1236A>C; p.A412A; 11:77336263-77336263

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.552T>C; p.A184A; 11:77358943-77358943

 pancreascarcinomaSubstitution - coding silent

c.231C>G; p.L77L; 11:77379954-77379954

 pancreascarcinomaSubstitution - coding silent

c.1045G>T; p.G349*; 11:77340717-77340717

 prostateadenomaSubstitution - Nonsense

c.59C>T; p.T20I; 11:77392462-77392462

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.236C>T; p.S79L; 11:77379949-77379949

 skin; upper_armmalignant_melanomaSubstitution - Missense

c.1595C>T; p.P532L; 11:77323317-77323317

 skinmalignant_melanomaSubstitution - Missense

c.711G>A; p.R237R; 11:77355729-77355729

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.951G>A; p.L317L; 11:77343866-77343866

 skinmalignant_melanomaSubstitution - coding silent

c.951G>A; p.L317L; 11:77343866-77343866

 skinmalignant_melanomaSubstitution - coding silent

c.1272G>A; p.M424I; 11:77336227-77336227

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.453G>A; p.E151E; 11:77374352-77374352

 skinmalignant_melanomaSubstitution - coding silent

c.1583C>T; p.S528F; 11:77323329-77323329

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.256C>T; p.H86Y; 11:77379929-77379929

 skinmalignant_melanomaSubstitution - Missense

c.478-1G>A; p.?; 11:77359018-77359018

 skinmalignant_melanomaUnknown

c.726G>A; p.Q242Q; 11:77355714-77355714

 skinmalignant_melanomaSubstitution - coding silent

c.1300G>A; p.E434K; 11:77336199-77336199

 skinmalignant_melanomaSubstitution - Missense

c.903G>A; p.M301I; 11:77343914-77343914

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1457A>G; p.N486S; 11:77332824-77332824

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.498G>C; p.E166D; 11:77358997-77358997

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.228T>G; p.S76S; 11:77379957-77379957

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.260T>C; p.V87A; 11:77379925-77379925

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.78C>A; p.A26A; 11:77392443-77392443

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.78C>A; p.A26A; 11:77392443-77392443

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.78C>A; p.A26A; 11:77392443-77392443

 stomachadenocarcinomaSubstitution - coding silent

c.319C>T; p.L107F; 11:77379361-77379361

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.772+1G>A; p.?; 11:77355667-77355667

 stomachcarcinoma; adenocarcinomaUnknown

c.556C>T; p.P186S; 11:77358939-77358939

 thyroidother; neoplasmSubstitution - Missense

c.132C>T; p.N44N; 11:77392389-77392389

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.132C>T; p.N44N; 11:77392389-77392389

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.205G>A; p.E69K; 11:77379980-77379980

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.205G>A; p.E69K; 11:77379980-77379980

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense