Entrez Gene

Basic Information
Gene ID	4739
Name	NEDD9
Synonymous	neural precursor cell expressed, developmentally down-regulated 9;NEDD9;neural precursor cell expressed, developmentally down-regulated 9
Definition	Cas scaffolding protein family member 2\|Crk-associated substrate related protein Cas-L\|Enhancer of filamentation 1 p55\|cas-like docking\|enhancer of filamentation 1\|neural precursor cell expressed developmentally down-regulated protein 9\|p130Cas-related pr
Position	6p24.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.962G>T; p.R321L; 6:11190907-11190907	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2182G>A; p.A728T; 6:11185485-11185485	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2238C>A; p.S746R; 6:11185429-11185429	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1128C>G; p.T376T; 6:11190741-11190741	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2328C>T; p.V776V; 6:11185339-11185339	breast	carcinoma	Substitution - coding silent
c.1080C>G; p.D360E; 6:11190789-11190789	breast	carcinoma	Substitution - Missense
c.1790A>T; p.Q597L; 6:11190079-11190079	breast	carcinoma	Substitution - Missense
c.932G>A; p.G311D; 6:11190937-11190937	breast	carcinoma	Substitution - Missense
c.1731G>A; p.T577T; 6:11190138-11190138	breast	carcinoma	Substitution - coding silent
c.1978C>T; p.Q660*; 6:11188235-11188235	breast	carcinoma	Substitution - Nonsense
c.1157C>T; p.S386F; 6:11190712-11190712	breast	carcinoma	Substitution - Missense
c.1730C>T; p.T577M; 6:11190139-11190139	breast	carcinoma	Substitution - Missense
c.1671C>T; p.F557F; 6:11190198-11190198	breast	carcinoma	Substitution - coding silent
c.771G>A; p.P257P; 6:11191098-11191098	breast	carcinoma	Substitution - coding silent
c.499G>A; p.E167K; 6:11193653-11193653	breast	carcinoma	Substitution - Missense
c.2378C>A; p.A793E; 6:11185289-11185289	breast	carcinoma	Substitution - Missense
c.967G>A; p.V323I; 6:11190902-11190902	breast	carcinoma	Substitution - Missense
c.74G>A; p.R25H; 6:11213666-11213666	breast	carcinoma	Substitution - Missense
c.2272T>C; p.F758L; 6:11185395-11185395	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1257C>T; p.A419A; 6:11190612-11190612	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.160A>G; p.I54V; 6:11213580-11213580	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1713G>T; p.E571D; 6:11190156-11190156	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.412G>T; p.V138L; 6:11213328-11213328	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2251C>A; p.L751I; 6:11185416-11185416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.499G>A; p.E167K; 6:11193653-11193653	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1130G>T; p.R377L; 6:11190739-11190739	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.334T>A; p.Y112N; 6:11213406-11213406	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.677C>T; p.P226L; 6:11191192-11191192	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.967G>A; p.V323I; 6:11190902-11190902	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.141A>G; p.S47S; 6:11213599-11213599	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.532G>A; p.D178N; 6:11193620-11193620	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.532G>A; p.D178N; 6:11193620-11193620	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.425T>C; p.I142T; 6:11213315-11213315	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.679C>T; p.P227S; 6:11191190-11191190	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.231T>C; p.P77P; 6:11213509-11213509	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.67G>A; p.A23T; 6:11213673-11213673	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.456A>G; p.K152K; 6:11213284-11213284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.734delC; p.P245fs*3; 6:11191135-11191135	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1401G>T; p.K467N; 6:11190468-11190468	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.419G>T; p.R140I; 6:11213321-11213321	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2055G>A; p.S685S; 6:11185612-11185612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2055G>A; p.S685S; 6:11185612-11185612	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2480C>T; p.S827F; 6:11185187-11185187	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.729C>T; p.F243F; 6:11191140-11191140	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.729C>T; p.F243F; 6:11191140-11191140	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.141A>G; p.S47S; 6:11213599-11213599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2229G>A; p.V743V; 6:11185438-11185438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2290A>G; p.T764A; 6:11185377-11185377	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326C>A; p.P109Q; 6:11213414-11213414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.947C>T; p.A316V; 6:11190922-11190922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1127C>G; p.T376S; 6:11190742-11190742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1955A>G; p.N652S; 6:11188258-11188258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.431delG; p.G144fs*11; 6:11213309-11213309	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1759C>T; p.Q587*; 6:11190110-11190110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.525C>T; p.D175D; 6:11193627-11193627	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2352C>T; p.C784C; 6:11185315-11185315	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2182G>A; p.A728T; 6:11185485-11185485	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2182G>A; p.A728T; 6:11185485-11185485	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2182G>A; p.A728T; 6:11185485-11185485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.568G>A; p.D190N; 6:11192440-11192440	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2218C>T; p.R740*; 6:11185449-11185449	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2392G>A; p.A798T; 6:11185275-11185275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2392G>A; p.A798T; 6:11185275-11185275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1056G>A; p.P352P; 6:11190813-11190813	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2367C>T; p.T789T; 6:11185300-11185300	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.946G>A; p.A316T; 6:11190923-11190923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.946G>A; p.A316T; 6:11190923-11190923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.134T>C; p.L45P; 6:11213606-11213606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2033A>C; p.K678T; 6:11185634-11185634	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.733C>G; p.P245A; 6:11191136-11191136	liver	carcinoma	Substitution - Missense
c.1184C>T; p.S395F; 6:11190685-11190685	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1971C>A; p.N657K; 6:11188242-11188242	liver	carcinoma	Substitution - Missense
c.1971C>A; p.N657K; 6:11188242-11188242	liver	carcinoma	Substitution - Missense
c.2301G>A; p.V767V; 6:11185366-11185366	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1507A>T; p.S503C; 6:11190362-11190362	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1261G>C; p.E421Q; 6:11190608-11190608	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2259A>T; p.A753A; 6:11185408-11185408	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.581C>G; p.S194*; 6:11192427-11192427	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.894C>T; p.S298S; 6:11190975-11190975	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1389C>T; p.L463L; 6:11190480-11190480	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2472C>G; p.F824L; 6:11185195-11185195	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2361C>G; p.L787L; 6:11185306-11185306	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.962G>A; p.R321Q; 6:11190907-11190907	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1733A>T; p.E578V; 6:11190136-11190136	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1300G>T; p.D434Y; 6:11190569-11190569	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.966C>G; p.G322G; 6:11190903-11190903	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.532G>A; p.D178N; 6:11193620-11193620	NS	malignant_melanoma	Substitution - Missense
c.1045C>T; p.L349L; 6:11190824-11190824	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1299C>T; p.T433T; 6:11190570-11190570	pancreas	carcinoma	Substitution - coding silent
c.729C>T; p.F243F; 6:11191140-11191140	pancreas	carcinoma	Substitution - coding silent
c.787A>G; p.I263V; 6:11191082-11191082	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.152G>A; p.R51Q; 6:11213588-11213588	prostate	carcinoma	Substitution - Missense
c.1504A>C; p.T502P; 6:11190365-11190365	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.967G>A; p.V323I; 6:11190902-11190902	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.283C>A; p.P95T; 6:11213457-11213457	skin	malignant_melanoma	Substitution - Missense
c.124G>A; p.G42R; 6:11213616-11213616	skin; ankle	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.893C>T; p.S298F; 6:11190976-11190976	skin	malignant_melanoma	Substitution - Missense
c.470C>T; p.P157L; 6:11193682-11193682	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1782C>A; p.H594Q; 6:11190087-11190087	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2416G>A; p.A806T; 6:11185251-11185251	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1912G>A; p.E638K; 6:11188301-11188301	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.362C>T; p.P121L; 6:11213378-11213378	skin	malignant_melanoma	Substitution - Missense
c.1022_1023GG>AA; p.R341K; 6:11190846-11190847	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.790C>T; p.P264S; 6:11191079-11191079	skin	malignant_melanoma	Substitution - Missense
c.2164C>T; p.L722F; 6:11185503-11185503	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.734C>T; p.P245L; 6:11191135-11191135	skin	malignant_melanoma	Substitution - Missense
c.1657G>A; p.A553T; 6:11190212-11190212	skin	malignant_melanoma	Substitution - Missense
c.442C>T; p.P148S; 6:11213298-11213298	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.526G>A; p.V176I; 6:11193626-11193626	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.702A>G; p.A234A; 6:11191167-11191167	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1299C>T; p.T433T; 6:11190570-11190570	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1618G>A; p.D540N; 6:11190251-11190251	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1735T>C; p.Y579H; 6:11190134-11190134	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.460-9C>G; p.?; 6:11193701-11193701	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.2001C>T; p.S667S; 6:11185666-11185666	stomach	adenocarcinoma	Substitution - coding silent
c.1617C>T; p.P539P; 6:11190252-11190252	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2182G>A; p.A728T; 6:11185485-11185485	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2182G>A; p.A728T; 6:11185485-11185485	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2182G>A; p.A728T; 6:11185485-11185485	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.903C>T; p.H301H; 6:11190966-11190966	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.651G>A; p.P217P; 6:11192357-11192357	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056G>A; p.P352P; 6:11190813-11190813	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.471C>T; p.P157P; 6:11193681-11193681	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.946G>A; p.A316T; 6:11190923-11190923	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.946G>A; p.A316T; 6:11190923-11190923	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1656C>T; p.N552N; 6:11190213-11190213	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1657G>A; p.A553T; 6:11190212-11190212	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.736C>T; p.P246S; 6:11191133-11191133	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1642A>T; p.T548S; 6:11190227-11190227	thyroid	other; neoplasm	Substitution - Missense
c.1504A>C; p.T502P; 6:11190365-11190365	thyroid	other; neoplasm	Substitution - Missense
c.1100G>A; p.R367Q; 6:11190769-11190769	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.168A>G; p.P56P; 6:11213572-11213572	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2296C>T; p.Q766*; 6:11185371-11185371	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1455G>A; p.M485I; 6:11190414-11190414	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1962G>A; p.M654I; 6:11188251-11188251	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1962G>A; p.M654I; 6:11188251-11188251	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1755G>A; p.Q585Q; 6:11190114-11190114	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1389C>G; p.L463L; 6:11190480-11190480	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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