Entrez Gene

Basic Information
Gene ID	4613
Name	MYCN
Synonymous	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog;MYCN;v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Definition	N-myc proto-oncogene protein\|class E basic helix-loop-helix protein 37\|neuroblastoma MYC oncogene\|neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene\|oncogene NMYC\|pp65/67
Position	2p24.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1392C>A; p.C464*; 2:15946094-15946094	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.997G>T; p.A333S; 2:15945699-15945699	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.904C>T; p.R302C; 2:15945606-15945606	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1365A>G; p.L455L; 2:15946067-15946067	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.207G>A; p.E69E; 2:15942271-15942271	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1201T>A; p.F401I; 2:15945903-15945903	breast	carcinoma	Substitution - Missense
c.903G>A; p.V301V; 2:15945605-15945605	breast	carcinoma	Substitution - coding silent
c.854G>A; p.R285Q; 2:15945556-15945556	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.173C>T; p.T58M; 2:15942237-15942237	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.173C>T; p.T58M; 2:15942237-15942237	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1095A>G; p.P365P; 2:15945797-15945797	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.131C>T; p.P44L; 2:15942195-15942195	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1186G>C; p.D396H; 2:15945888-15945888	central_nervous_system; brain	glioma	Substitution - Missense
c.962A>G; p.K321R; 2:15945664-15945664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.831C>T; p.I277I; 2:15945533-15945533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.131C>T; p.P44L; 2:15942195-15942195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1157A>G; p.H386R; 2:15945859-15945859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.533delA; p.E178fs*20; 2:15942597-15942597	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Deletion - Frameshift
c.72A>G; p.L24L; 2:15942136-15942136	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.805G>A; p.E269K; 2:15945507-15945507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.957C>T; p.I319I; 2:15945659-15945659	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.131C>T; p.P44L; 2:15942195-15942195	kidney	Wilms_tumour	Substitution - Missense
c.1186G>A; p.D396N; 2:15945888-15945888	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>A; p.P44H; 2:15942195-15942195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>A; p.P44H; 2:15942195-15942195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1074G>T; p.P358P; 2:15945776-15945776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.127_128insC; p.E47fs*8; 2:15942191-15942192	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1319delT; p.L441fs*15; 2:15946021-15946021	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.135delG; p.E47fs*84; 2:15942199-15942199	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.846G>A; p.V282V; 2:15945548-15945548	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.186G>A; p.S62S; 2:15942250-15942250	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.100G>T; p.D34Y; 2:15942164-15942164	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1385G>A; p.R462Q; 2:15946087-15946087	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1118G>A; p.R373Q; 2:15945820-15945820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1118G>A; p.R373Q; 2:15945820-15945820	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.190A>G; p.S64G; 2:15942254-15942254	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1144C>T; p.R382C; 2:15945846-15945846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1069C>T; p.R357C; 2:15945771-15945771	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1074G>A; p.P358P; 2:15945776-15945776	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.128delC; p.P45fs*86; 2:15942192-15942192	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.128delC; p.P45fs*86; 2:15942192-15942192	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.128delC; p.P45fs*86; 2:15942192-15942192	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.128delC; p.P45fs*86; 2:15942192-15942192	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.385G>A; p.A129T; 2:15942449-15942449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1284G>A; p.E428E; 2:15945986-15945986	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1205T>C; p.L402P; 2:15945907-15945907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.856C>T; p.R286C; 2:15945558-15945558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.860C>T; p.S287F; 2:15945562-15945562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1039C>A; p.Q347K; 2:15945741-15945741	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1093C>A; p.P365T; 2:15945795-15945795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.904C>T; p.R302C; 2:15945606-15945606	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.904C>T; p.R302C; 2:15945606-15945606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.170C>A; p.P57H; 2:15942234-15942234	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.170C>A; p.P57H; 2:15942234-15942234	large_intestine; colon	carcinoma	Substitution - Missense
c.1132G>T; p.E378*; 2:15945834-15945834	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1144C>T; p.R382C; 2:15945846-15945846	liver	carcinoma	Substitution - Missense
c.1040A>G; p.Q347R; 2:15945742-15945742	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.225G>T; p.P75P; 2:15942289-15942289	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1204C>T; p.L402F; 2:15945906-15945906	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1351C>G; p.Q451E; 2:15946053-15946053	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1193G>T; p.R398L; 2:15945895-15945895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1186G>T; p.D396Y; 2:15945888-15945888	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.954G>T; p.L318L; 2:15945656-15945656	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.672T>G; p.G224G; 2:15942736-15942736	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>T; p.L402L; 2:15945908-15945908	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1323G>C; p.L441F; 2:15946025-15946025	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.8G>T; p.S3I; 2:15942072-15942072	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>A; p.M1I; 2:15942067-15942067	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.333C>T; p.I111I; 2:15942397-15942397	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1132G>A; p.E378K; 2:15945834-15945834	NS	malignant_melanoma	Substitution - Missense
c.1033C>A; p.P345T; 2:15945735-15945735	NS	NS	Substitution - Missense
c.711G>A; p.P237P; 2:15942775-15942775	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1336A>C; p.K446Q; 2:15946038-15946038	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.266G>A; p.G89D; 2:15942330-15942330	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1073C>T; p.P358L; 2:15945775-15945775	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1107C>A; p.S369R; 2:15945809-15945809	pancreas	carcinoma	Substitution - Missense
c.131C>T; p.P44L; 2:15942195-15942195	pancreas	other; adenoma	Substitution - Missense
c.725G>T; p.R242L; 2:15942789-15942789	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.296T>C; p.L99P; 2:15942360-15942360	prostate	carcinoma	Substitution - Missense
c.1042A>G; p.K348E; 2:15945744-15945744	salivary_gland; parotid	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1333G>A; p.E445K; 2:15946035-15946035	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1333G>A; p.E445K; 2:15946035-15946035	skin	malignant_melanoma	Substitution - Missense
c.1333G>A; p.E445K; 2:15946035-15946035	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.919G>A; p.A307T; 2:15945621-15945621	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.965G>A; p.R322Q; 2:15945667-15945667	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1287T>A; p.Y429*; 2:15945989-15945989	skin	malignant_melanoma	Substitution - Nonsense
c.1003C>T; p.P335S; 2:15945705-15945705	skin	malignant_melanoma	Substitution - Missense
c.125C>T; p.S42L; 2:15942189-15942189	skin	malignant_melanoma	Substitution - Missense
c.1296C>A; p.S432S; 2:15945998-15945998	skin	malignant_melanoma	Substitution - coding silent
c.1073C>T; p.P358L; 2:15945775-15945775	skin; trunk	malignant_melanoma	Substitution - Missense
c.915C>T; p.N305N; 2:15945617-15945617	skin	malignant_melanoma	Substitution - coding silent
c.136G>A; p.G46R; 2:15942200-15942200	skin	malignant_melanoma	Substitution - Missense
c.1007C>T; p.S336F; 2:15945709-15945709	skin	malignant_melanoma	Substitution - Missense
c.91G>A; p.D31N; 2:15942155-15942155	skin	malignant_melanoma	Substitution - Missense
c.1368G>A; p.K456K; 2:15946070-15946070	skin	malignant_melanoma	Substitution - coding silent
c.1368G>A; p.K456K; 2:15946070-15946070	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1368G>A; p.K456K; 2:15946070-15946070	skin	malignant_melanoma	Substitution - coding silent
c.365delC; p.R123fs*8; 2:15942429-15942429	skin; abdomen	malignant_melanoma	Deletion - Frameshift
c.221C>T; p.P74L; 2:15942285-15942285	skin	malignant_melanoma	Substitution - Missense
c.1092C>T; p.P364P; 2:15945794-15945794	skin	malignant_melanoma	Substitution - coding silent
c.1192C>T; p.R398W; 2:15945894-15945894	skin	malignant_melanoma	Substitution - Missense
c.1067C>T; p.P356L; 2:15945769-15945769	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.267C>A; p.G89G; 2:15942331-15942331	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1004C>T; p.P335L; 2:15945706-15945706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.134C>T; p.P45L; 2:15942198-15942198	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.128delC; p.P45fs*86; 2:15942192-15942192	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.426C>G; p.T142T; 2:15942490-15942490	thyroid	other; neoplasm	Substitution - coding silent
c.383G>A; p.R128H; 2:15942447-15942447	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.105C>T; p.F35F; 2:15942169-15942169	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.370G>A; p.E124K; 2:15942434-15942434	urinary_tract; bladder	carcinoma	Substitution - Missense
c.58G>C; p.E20Q; 2:15942122-15942122	urinary_tract; bladder	carcinoma	Substitution - Missense
c.805G>T; p.E269*; 2:15945507-15945507	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.867C>T; p.S289S; 2:15945569-15945569	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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