Entrez Gene

Basic Information
Gene ID	4361
Name	MRE11A
Synonymous	MRE11 meiotic recombination 11 homolog A (S. cerevisiae);MRE11A;MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Definition	AT-like disease\|DNA recombination and repair protein\|MRE11 homolog 1\|MRE11 homolog A\|double-strand break repair protein MRE11A\|endo/exonuclease Mre11\|meiotic recombination 11 homolog 1\|meiotic recombination 11 homolog A
Position	11q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1351G>C; p.E451Q; 11:94459557-94459557	breast	carcinoma	Substitution - Missense
c.710T>G; p.F237C; 11:94471709-94471709	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.229G>A; p.E77K; 11:94486009-94486009	breast	carcinoma	Substitution - Missense
c.1146C>T; p.S382S; 11:94464192-94464192	breast	carcinoma; ER-PR-positive_carcinoma	Substitution - coding silent
c.904C>T; p.H302Y; 11:94470584-94470584	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.904C>T; p.H302Y; 11:94470584-94470584	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.904C>T; p.H302Y; 11:94470584-94470584	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1287A>G; p.V429V; 11:94460975-94460975	breast	carcinoma	Substitution - coding silent
c.1951C>A; p.Q651K; 11:94429946-94429946	breast	carcinoma	Substitution - Missense
c.1318G>A; p.A440T; 11:94460944-94460944	breast	carcinoma	Substitution - Missense
c.1507C>T; p.R503C; 11:94456332-94456332	breast	carcinoma	Substitution - Missense
c.652C>A; p.Q218K; 11:94476296-94476296	breast	carcinoma	Substitution - Missense
c.1205G>A; p.R402K; 11:94464133-94464133	breast	carcinoma	Substitution - Missense
c.1964G>T; p.G655V; 11:94429933-94429933	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1385T>A; p.V462E; 11:94459523-94459523	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1398G>A; p.E466E; 11:94459510-94459510	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1504C>T; p.R502C; 11:94456335-94456335	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.763A>G; p.K255E; 11:94471656-94471656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1552G>T; p.E518*; 11:94456287-94456287	endometrium	carcinoma; serous_carcinoma	Substitution - Nonsense
c.853G>T; p.G285C; 11:94470635-94470635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1582G>A; p.A528T; 11:94447420-94447420	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.43A>C; p.I15L; 11:94490943-94490943	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1378G>T; p.E460*; 11:94459530-94459530	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1640G>T; p.S547I; 11:94447362-94447362	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1318G>A; p.A440T; 11:94460944-94460944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1959G>A; p.S653S; 11:94429938-94429938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1959G>A; p.S653S; 11:94429938-94429938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.449T>C; p.V150A; 11:94478830-94478830	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1429C>G; p.Q477E; 11:94459479-94459479	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.862C>T; p.R288C; 11:94470626-94470626	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Missense
c.1795A>G; p.T599A; 11:94437224-94437224	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1890C>T; p.T630T; 11:94435852-94435852	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.282C>A; p.L94L; 11:94485956-94485956	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1783G>T; p.A595S; 11:94447219-94447219	kidney	other; neoplasm	Substitution - Missense
c.130T>G; p.L44V; 11:94490856-94490856	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.910G>A; p.V304M; 11:94470578-94470578	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.585T>C; p.N195N; 11:94476363-94476363	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1139G>A; p.R380H; 11:94464199-94464199	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.E77K; 11:94486009-94486009	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.863G>A; p.R288H; 11:94470625-94470625	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.904C>A; p.H302N; 11:94470584-94470584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.710T>C; p.F237S; 11:94471709-94471709	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.710T>C; p.F237S; 11:94471709-94471709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.710T>C; p.F237S; 11:94471709-94471709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1521C>A; p.T507T; 11:94456318-94456318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1196delT; p.F399fs*29; 11:94464142-94464142	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1757C>T; p.S586L; 11:94447245-94447245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1505G>A; p.R502H; 11:94456334-94456334	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.151G>A; p.E51K; 11:94490835-94490835	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1626T>C; p.A542A; 11:94447376-94447376	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1626T>C; p.A542A; 11:94447376-94447376	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1098+2T>A; p.?; 11:94467811-94467811	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.1180G>T; p.D394Y; 11:94464158-94464158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.708C>T; p.D236D; 11:94471711-94471711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1584A>G; p.A528A; 11:94447418-94447418	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1378G>T; p.E460*; 11:94459530-94459530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.228C>T; p.L76L; 11:94486010-94486010	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1820T>C; p.V607A; 11:94437199-94437199	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1441delA; p.T481fs*43; 11:94459467-94459467	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1441delA; p.T481fs*43; 11:94459467-94459467	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1441delA; p.T481fs*43; 11:94459467-94459467	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1138C>T; p.R380C; 11:94464200-94464200	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.709T>C; p.F237L; 11:94471710-94471710	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.709T>C; p.F237L; 11:94471710-94471710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.709T>C; p.F237L; 11:94471710-94471710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.894A>C; p.K298N; 11:94470594-94470594	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.711C>T; p.F237F; 11:94471708-94471708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1532delA; p.N511fs*13; 11:94456307-94456307	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1532delA; p.N511fs*13; 11:94456307-94456307	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1532delA; p.N511fs*13; 11:94456307-94456307	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1532delA; p.N511fs*13; 11:94456307-94456307	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.139G>T; p.A47S; 11:94490847-94490847	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.58G>T; p.D20Y; 11:94490928-94490928	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1480G>A; p.E494K; 11:94459428-94459428	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2010G>T; p.M670I; 11:94420158-94420158	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1098+10A>G; p.?; 11:94467803-94467803	liver	carcinoma	Unknown
c.1098+10A>G; p.?; 11:94467803-94467803	liver	carcinoma	Unknown
c.694C>T; p.Q232*; 11:94471725-94471725	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.314+6T>C; p.?; 11:94485918-94485918	liver	carcinoma	Unknown
c.314+6T>C; p.?; 11:94485918-94485918	liver	carcinoma	Unknown
c.72A>G; p.G24G; 11:94490914-94490914	liver	carcinoma	Substitution - coding silent
c.1564-2A>T; p.?; 11:94447440-94447440	liver	carcinoma	Unknown
c.1564-2A>T; p.?; 11:94447440-94447440	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.237A>T; p.L79F; 11:94486001-94486001	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.530C>G; p.A177G; 11:94478749-94478749	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.366G>T; p.V122V; 11:94479710-94479710	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1777_1778GG>AA; p.G593K; 11:94447224-94447225	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1777_1778GG>AA; p.G593K; 11:94447224-94447225	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1043A>T; p.E348V; 11:94467868-94467868	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.157G>T; p.D53Y; 11:94486081-94486081	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.853G>T; p.G285C; 11:94470635-94470635	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1746G>A; p.Q582Q; 11:94447256-94447256	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1559G>C; p.R520P; 11:94456280-94456280	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.616G>T; p.D206Y; 11:94476332-94476332	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1688C>T; p.S563L; 11:94447314-94447314	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1714C>T; p.R572*; 11:94447288-94447288	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1651G>A; p.A551T; 11:94447351-94447351	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.256G>A; p.D86N; 11:94485982-94485982	lung	carcinoma; mucoepidermoid_carcinoma	Substitution - Missense
c.1575G>T; p.R525S; 11:94447427-94447427	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.928G>T; p.E310*; 11:94470560-94470560	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.332A>C; p.Y111S; 11:94479744-94479744	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.742G>A; p.E248K; 11:94471677-94471677	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.515G>A; p.G172E; 11:94478764-94478764	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.315-5_315-4delTT; p.?; 11:94479765-94479766	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.93C>T; p.V31V; 11:94490893-94490893	oesophagus	carcinoma	Substitution - coding silent
c.1327-2A>G; p.?; 11:94459583-94459583	ovary	carcinoma; serous_carcinoma	Unknown
c.597A>T; p.T199T; 11:94476351-94476351	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.315-4delT; p.?; 11:94479765-94479765	ovary	carcinoma; serous_carcinoma	Unknown
c.194A>T; p.N65I; 11:94486044-94486044	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.194A>T; p.N65I; 11:94486044-94486044	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.142C>T; p.Q48*; 11:94490844-94490844	skin	malignant_melanoma	Substitution - Nonsense
c.1944C>T; p.S648S; 11:94429953-94429953	skin	malignant_melanoma	Substitution - coding silent
c.1870G>A; p.E624K; 11:94435872-94435872	skin	malignant_melanoma	Substitution - Missense
c.154-3C>G; p.?; 11:94486087-94486087	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1069C>A; p.Q357K; 11:94467842-94467842	skin	malignant_melanoma	Substitution - Missense
c.2002C>T; p.P668S; 11:94420166-94420166	skin	malignant_melanoma	Substitution - Missense
c.1688C>T; p.S563L; 11:94447314-94447314	skin	malignant_melanoma	Substitution - Missense
c.1558C>T; p.R520C; 11:94456281-94456281	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.711C>T; p.F237F; 11:94471708-94471708	skin	malignant_melanoma	Substitution - coding silent
c.818C>T; p.S273F; 11:94471601-94471601	skin	malignant_melanoma	Substitution - Missense
c.1491C>T; p.I497I; 11:94459417-94459417	skin	malignant_melanoma	Substitution - coding silent
c.1189C>T; p.H397Y; 11:94464149-94464149	skin	malignant_melanoma	Substitution - Missense
c.1196delT; p.F399fs*29; 11:94464142-94464142	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1090C>T; p.R364*; 11:94467821-94467821	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.466T>C; p.S156P; 11:94478813-94478813	stomach	adenocarcinoma	Substitution - Missense
c.1629T>C; p.D543D; 11:94447373-94447373	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.29A>G; p.E10G; 11:94490957-94490957	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1184T>C; p.I395T; 11:94464154-94464154	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1532delA; p.N511fs*13; 11:94456307-94456307	stomach	adenocarcinoma	Deletion - Frameshift
c.568T>C; p.Y190H; 11:94476380-94476380	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1784C>T; p.A595V; 11:94437235-94437235	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1046G>T; p.R349L; 11:94467865-94467865	urinary_tract; bladder	carcinoma	Substitution - Missense
c.92T>G; p.V31G; 11:94490894-94490894	urinary_tract; bladder	carcinoma	Substitution - Missense
c.92T>G; p.V31G; 11:94490894-94490894	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1326+1G>C; p.?; 11:94460935-94460935	urinary_tract; bladder	carcinoma	Unknown

Oncogene database

COSMIC confirmed somatic mutation [Top]

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