Entrez Gene

Basic Information
Gene ID	4211
Name	MEIS1
Synonymous	Meis homeobox 1;MEIS1;Meis homeobox 1
Definition	Meis1, myeloid ecotropic viral integration site 1 homolog\|WUGSC:H_NH0444B04.1\|homeobox protein Meis1\|leukemogenic homolog protein
Position	2p14
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.220G>T; p.D74Y; 2:66437944-66437944	breast	carcinoma	Substitution - Missense
c.826C>T; p.R276C; 2:66512232-66512232	breast	carcinoma	Substitution - Missense
c.81G>A; p.P27P; 2:66437805-66437805	breast	carcinoma	Substitution - coding silent
c.298A>C; p.T100P; 2:66439901-66439901	breast	carcinoma	Substitution - Missense
c.269T>A; p.I90N; 2:66439872-66439872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.671G>T; p.R224L; 2:66464149-66464149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1069G>A; p.G357S; 2:66568711-66568711	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.513delC; p.R172fs*6; 2:66442931-66442931	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.274G>T; p.E92*; 2:66439877-66439877	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.15C>T; p.Y5Y; 2:66437739-66437739	kidney	other; neoplasm	Substitution - coding silent
c.712T>C; p.S238P; 2:66464190-66464190	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.671G>A; p.R224H; 2:66464149-66464149	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.306C>T; p.R102R; 2:66439909-66439909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.779C>G; p.T260R; 2:66512185-66512185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.K268N; 2:66512210-66512210	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.65C>T; p.T22M; 2:66437789-66437789	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.R102C; 2:66439907-66439907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1076T>C; p.V359A; 2:66568718-66568718	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1076T>C; p.V359A; 2:66568718-66568718	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1076T>C; p.V359A; 2:66568718-66568718	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.388G>A; p.A130T; 2:66440568-66440568	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.205G>T; p.D69Y; 2:66437929-66437929	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.19G>A; p.D7N; 2:66437743-66437743	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.312delG; p.V106fs*16; 2:66439915-66439915	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.299delC; p.R102fs*20; 2:66439902-66439902	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1135A>G; p.M379V; 2:66569070-66569070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>T; p.R203I; 2:66443026-66443026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.700G>A; p.G234S; 2:66464178-66464178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.770delC; p.S259fs*24; 2:66512176-66512176	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.587_590delCAGA; p.D197fs*4; 2:66443005-66443008	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.298_299insC; p.R102fs*18; 2:66439901-66439902	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.986G>T; p.R329I; 2:66567473-66567473	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.793G>T; p.D265Y; 2:66512199-66512199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.742+2delT; p.?; 2:66464222-66464222	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.480G>T; p.E160D; 2:66441461-66441461	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.480G>T; p.E160D; 2:66441461-66441461	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.544C>T; p.P182S; 2:66442962-66442962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>A; p.P373H; 2:66569053-66569053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.514C>T; p.R172W; 2:66442932-66442932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.871C>T; p.L291L; 2:66512277-66512277	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.871C>T; p.L291L; 2:66512277-66512277	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.25C>T; p.P9S; 2:66437749-66437749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.814C>T; p.R272C; 2:66512220-66512220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.717C>G; p.H239Q; 2:66464195-66464195	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1147A>G; p.M383V; 2:66569082-66569082	liver	carcinoma	Substitution - Missense
c.482A>C; p.K161T; 2:66441463-66441463	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.382-1G>T; p.?; 2:66440561-66440561	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.1150G>A; p.E384K; 2:66569085-66569085	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.921G>T; p.Q307H; 2:66547975-66547975	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1019G>A; p.R340Q; 2:66567506-66567506	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.R129R; 2:66440567-66440567	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.674C>G; p.S225*; 2:66464152-66464152	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1027A>C; p.S343R; 2:66568669-66568669	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.866C>T; p.A289V; 2:66512272-66512272	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>G; p.L141V; 2:66440601-66440601	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.583A>G; p.K195E; 2:66443001-66443001	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.870G>C; p.W290C; 2:66512276-66512276	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1143G>T; p.M381I; 2:66569078-66569078	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.153G>A; p.P51P; 2:66437877-66437877	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1084G>A; p.G362S; 2:66568726-66568726	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.330C>T; p.D110D; 2:66439933-66439933	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.34G>A; p.G12R; 2:66437758-66437758	prostate	carcinoma	Substitution - Missense
c.1019G>A; p.R340Q; 2:66567506-66567506	prostate	carcinoma	Substitution - Missense
c.972T>G; p.I324M; 2:66567459-66567459	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.838C>T; p.P280S; 2:66512244-66512244	skin	malignant_melanoma	Substitution - Missense
c.58C>T; p.P20S; 2:66437782-66437782	skin; extremity	malignant_melanoma	Substitution - Missense
c.691C>T; p.P231S; 2:66464169-66464169	skin	malignant_melanoma	Substitution - Missense
c.400C>T; p.L134L; 2:66440580-66440580	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.400C>T; p.L134L; 2:66440580-66440580	skin	malignant_melanoma	Substitution - coding silent
c.1019G>A; p.R340Q; 2:66567506-66567506	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1087C>T; p.Q363*; 2:66568729-66568729	skin	malignant_melanoma	Substitution - Nonsense
c.1013_1014CC>TT; p.S338F; 2:66567500-66567501	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.267G>A; p.L89L; 2:66439870-66439870	skin	malignant_melanoma	Substitution - coding silent
c.1033G>A; p.G345R; 2:66568675-66568675	skin	malignant_melanoma	Substitution - Missense
c.695C>T; p.S232F; 2:66464173-66464173	skin	malignant_melanoma	Substitution - Missense
c.302C>T; p.P101L; 2:66439905-66439905	skin	malignant_melanoma	Substitution - Missense
c.1167C>T; p.Y389Y; 2:66569102-66569102	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.485T>C; p.V162A; 2:66442903-66442903	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.307G>A; p.E103K; 2:66439910-66439910	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.923T>C; p.L308S; 2:66547977-66547977	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>A; p.K268K; 2:66512210-66512210	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.364G>A; p.A122T; 2:66439967-66439967	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.738G>T; p.E246D; 2:66464216-66464216	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.738G>T; p.E246D; 2:66464216-66464216	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.66G>A; p.T22T; 2:66437790-66437790	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1087C>T; p.Q363*; 2:66568729-66568729	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.902C>T; p.S301F; 2:66547956-66547956	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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