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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

4170

Name

MCL1

Synonymous

myeloid cell leukemia 1;MCL1;myeloid cell leukemia 1

Definition

bcl-2-like protein 3|bcl-2-related protein EAT/mcl1|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia ES|myeloid cell leukemia sequence 1 (BCL2-related)

Position

1q21

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.583G>T; p.D195Y; 1:150578948-150578948

 bone; femurchondrosarcomaSubstitution - Missense

c.724G>A; p.D242N; 1:150578456-150578456

 breastcarcinomaSubstitution - Missense

c.648T>A; p.V216V; 1:150578883-150578883

 breastcarcinomaSubstitution - coding silent

c.870A>C; p.L290F; 1:150578310-150578310

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.520T>C; p.L174L; 1:150579011-150579011

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.441C>T; p.V147V; 1:150579090-150579090

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.970C>A; p.L324I; 1:150577458-150577458

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.278C>G; p.P93R; 1:150579253-150579253

 eye; uveal_tractmalignant_melanoma; spindleSubstitution - Missense

c.481C>T; p.P161S; 1:150579050-150579050

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.522G>A; p.L174L; 1:150579009-150579009

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.660G>A; p.V220V; 1:150578871-150578871

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.390G>A; p.E130E; 1:150579141-150579141

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.954C>T; p.F318F; 1:150577474-150577474

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.573C>T; p.T191T; 1:150578958-150578958

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.329A>G; p.E110G; 1:150579202-150579202

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.430C>T; p.L144L; 1:150579101-150579101

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.513_515delGGA; p.E171delE; 1:150579016-150579018

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.513_515delGGA; p.E171delE; 1:150579016-150579018

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.804T>C; p.I268I; 1:150578376-150578376

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.520T>C; p.L174L; 1:150579011-150579011

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.442G>A; p.G148R; 1:150579089-150579089

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.465T>G; p.S155R; 1:150579066-150579066

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.57C>A; p.A19A; 1:150579474-150579474

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.643C>G; p.R215G; 1:150578888-150578888

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.699G>C; p.R233R; 1:150578481-150578481

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.559C>T; p.R187W; 1:150578972-150578972

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.590A>T; p.K197M; 1:150578941-150578941

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.315G>T; p.A105A; 1:150579216-150579216

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1042C>G; p.L348V; 1:150577386-150577386

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.894C>A; p.L298L; 1:150578286-150578286

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.367G>A; p.E123K; 1:150579164-150579164

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.738G>T; p.L246F; 1:150578442-150578442

 oesophaguscarcinomaSubstitution - Missense

c.660G>A; p.V220V; 1:150578871-150578871

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.282G>C; p.A94A; 1:150579249-150579249

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.638T>A; p.L213*; 1:150578893-150578893

 pancreascarcinomaSubstitution - Nonsense

c.638T>A; p.L213*; 1:150578893-150578893

 pancreascarcinomaSubstitution - Nonsense

c.652G>A; p.D218N; 1:150578879-150578879

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.461C>T; p.T154I; 1:150579070-150579070

 skinmalignant_melanomaSubstitution - Missense

c.699G>A; p.R233R; 1:150578481-150578481

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.194C>T; p.P65L; 1:150579337-150579337

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.513_515delGGA; p.E171delE; 1:150579016-150579018

 skinmalignant_melanomaDeletion - In frame

c.635C>T; p.T212I; 1:150578896-150578896

 skinmalignant_melanomaSubstitution - Missense

c.913T>G; p.W305G; 1:150578267-150578267

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1038A>G; p.A346A; 1:150577390-150577390

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.143T>A; p.I48K; 1:150579388-150579388

 stomachcarcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableSubstitution - Missense

c.559C>T; p.R187W; 1:150578972-150578972

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.882C>T; p.I294I; 1:150578298-150578298

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.282G>C; p.A94A; 1:150579249-150579249

 urinary_tract; bladdercarcinomaSubstitution - coding silent