Entrez Gene

Basic Information
Gene ID	4163
Name	MCC
Synonymous	mutated in colorectal cancers;MCC;mutated in colorectal cancers
Definition	colorectal mutant cancer protein
Position	5q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.703C>T; p.L235L; 5:113101864-113101864	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.545G>C; p.S182T; 5:113104268-113104268	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1444G>A; p.V482M; 5:113068095-113068095	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1304T>G; p.V435G; 5:113071145-113071145	breast	carcinoma	Substitution - Missense
c.691T>G; p.W231G; 5:113101876-113101876	breast	carcinoma	Substitution - Missense
c.2476G>A; p.E826K; 5:113027316-113027316	breast	carcinoma	Substitution - Missense
c.969C>G; p.I323M; 5:113085170-113085170	breast	carcinoma	Substitution - Missense
c.373A>T; p.N125Y; 5:113122768-113122768	breast	carcinoma	Substitution - Missense
c.2283C>T; p.F761F; 5:113028960-113028960	breast	carcinoma	Substitution - coding silent
c.552C>A; p.S184S; 5:113104261-113104261	central_nervous_system; brain	glioma	Substitution - coding silent
c.2260C>T; p.R754*; 5:113028983-113028983	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.552C>T; p.S184S; 5:113104261-113104261	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1423G>A; p.G475R; 5:113068116-113068116	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1378G>A; p.E460K; 5:113068161-113068161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2085+9G>A; p.?; 5:113049084-113049084	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2108C>A; p.P703Q; 5:113043608-113043608	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.386G>A; p.R129Q; 5:113122755-113122755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2227G>T; p.A743S; 5:113029016-113029016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1745C>T; p.A582V; 5:113053858-113053858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2367G>C; p.K789N; 5:113027425-113027425	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1487C>A; p.T496N; 5:113064140-113064140	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2148G>T; p.E716D; 5:113043568-113043568	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1957C>T; p.R653W; 5:113049221-113049221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.424G>A; p.E142K; 5:113122717-113122717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221C>T; p.T74M; 5:113143311-113143311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221C>T; p.T74M; 5:113143311-113143311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2375C>T; p.S792L; 5:113027417-113027417	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1331C>T; p.A444V; 5:113071118-113071118	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.847C>T; p.R283*; 5:113085292-113085292	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2376G>A; p.S792S; 5:113027416-113027416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2283C>T; p.F761F; 5:113028960-113028960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2283C>T; p.F761F; 5:113028960-113028960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1444G>A; p.V482M; 5:113068095-113068095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.376G>A; p.E126K; 5:113122765-113122765	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.124A>G; p.T42A; 5:113151356-113151356	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1284C>T; p.A428A; 5:113071165-113071165	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2385G>A; p.M795I; 5:113027407-113027407	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.393_394GG>AA; p.M131_D132>IN; 5:113122747-113122748	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Complex - compound substitution
c.347A>C; p.E116A; 5:113122794-113122794	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.744G>A; p.M248I; 5:113101823-113101823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.435T>A; p.S145S; 5:113122706-113122706	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.241C>T; p.R81C; 5:113143291-113143291	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.160G>T; p.A54S; 5:113151320-113151320	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1695C>T; p.D565D; 5:113053908-113053908	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1469C>T; p.S490L; 5:113064158-113064158	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.552C>T; p.S184S; 5:113104261-113104261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.739G>A; p.A247T; 5:113101828-113101828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2141G>T; p.C714F; 5:113043575-113043575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2483C>T; p.S828L; 5:113027309-113027309	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.911C>T; p.P304L; 5:113085228-113085228	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.858C>T; p.S286S; 5:113085281-113085281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.386G>A; p.R129Q; 5:113122755-113122755	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine; colon	carcinoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.86A>G; p.K29R; 5:113151394-113151394	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.815G>A; p.R272Q; 5:113101752-113101752	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.907C>T; p.R303C; 5:113085232-113085232	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984G>A; p.E328E; 5:113084182-113084182	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>A; p.E328E; 5:113084182-113084182	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>A; p.E328E; 5:113084182-113084182	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.208G>A; p.V70I; 5:113143324-113143324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.745C>T; p.L249L; 5:113101822-113101822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.534G>A; p.K178K; 5:113104279-113104279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.113G>A; p.R38H; 5:113151367-113151367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113G>A; p.R38H; 5:113151367-113151367	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.507G>A; p.L169L; 5:113104306-113104306	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.424G>A; p.E142K; 5:113122717-113122717	large_intestine; colon	NS	Substitution - Missense
c.2145C>T; p.S715S; 5:113043571-113043571	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2145C>T; p.S715S; 5:113043571-113043571	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2283C>A; p.F761L; 5:113028960-113028960	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.9C>T; p.S3S; 5:113294377-113294377	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1751A>G; p.K584R; 5:113053852-113053852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1184A>T; p.E395V; 5:113082890-113082890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1392G>A; p.A464A; 5:113068147-113068147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1285G>A; p.E429K; 5:113071164-113071164	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1285G>A; p.E429K; 5:113071164-113071164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1671C>T; p.C557C; 5:113053932-113053932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.863A>G; p.Q288R; 5:113085276-113085276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2375C>T; p.S792L; 5:113027417-113027417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2375C>T; p.S792L; 5:113027417-113027417	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.L216F; 5:113101921-113101921	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.293G>A; p.R98H; 5:113143239-113143239	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1357G>A; p.E453K; 5:113068182-113068182	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.252G>A; p.E84E; 5:113143280-113143280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1391delC; p.A464fs*55; 5:113068148-113068148	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1502G>A; p.R501Q; 5:113064125-113064125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1955C>T; p.T652M; 5:113049223-113049223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.140A>G; p.D47G; 5:113151340-113151340	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>T; p.R77C; 5:113143303-113143303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.580C>A; p.Q194K; 5:113104233-113104233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1438G>T; p.A480S; 5:113068101-113068101	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2283C>T; p.F761F; 5:113028960-113028960	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2283C>T; p.F761F; 5:113028960-113028960	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1283C>T; p.A428V; 5:113071166-113071166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.241C>T; p.R81C; 5:113143291-113143291	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.458-1G>T; p.?; 5:113104356-113104356	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.458-1G>T; p.?; 5:113104356-113104356	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.58-5C>T; p.?; 5:113151427-113151427	liver	carcinoma	Unknown
c.58-5C>T; p.?; 5:113151427-113151427	liver	carcinoma	Unknown
c.2476G>C; p.E826Q; 5:113027316-113027316	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1239A>G; p.Q413Q; 5:113071210-113071210	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1313A>G; p.Y438C; 5:113071136-113071136	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1066-1G>C; p.?; 5:113083009-113083009	lung	carcinoma; adenocarcinoma	Unknown
c.1694A>G; p.D565G; 5:113053909-113053909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1107G>C; p.Q369H; 5:113082967-113082967	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2068A>T; p.K690*; 5:113049110-113049110	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1070C>G; p.S357C; 5:113083004-113083004	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.771C>G; p.N257K; 5:113101796-113101796	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1693G>A; p.D565N; 5:113053910-113053910	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>T; p.E269*; 5:113101762-113101762	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1032G>T; p.R344R; 5:113084134-113084134	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1779C>G; p.I593M; 5:113053824-113053824	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2205C>T; p.A735A; 5:113029038-113029038	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.827G>A; p.R276K; 5:113101740-113101740	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.65C>A; p.S22*; 5:113151415-113151415	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.302G>T; p.G101V; 5:113143230-113143230	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.522C>T; p.C174C; 5:113104291-113104291	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.42G>A; p.S14S; 5:113294344-113294344	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1786G>A; p.D596N; 5:113053817-113053817	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1355+5_1355+6ins14; p.?; 5:113071088-113071089	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.2289delT; p.N763fs*3; 5:113028954-113028954	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1521G>T; p.K507N; 5:113064106-113064106	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2260C>T; p.R754*; 5:113028983-113028983	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.86A>T; p.K29M; 5:113151394-113151394	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.57G>A; p.E19E; 5:113294329-113294329	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.813C>A; p.D271E; 5:113101754-113101754	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.975+4A>G; p.?; 5:113085160-113085160	pancreas	other; adenoma	Unknown
c.2406G>T; p.E802D; 5:113027386-113027386	pancreas	carcinoma	Substitution - Missense
c.2406G>T; p.E802D; 5:113027386-113027386	pancreas	carcinoma	Substitution - Missense
c.1068A>G; p.V356V; 5:113083006-113083006	pancreas	carcinoma	Substitution - coding silent
c.262G>A; p.V88I; 5:113143270-113143270	prostate	carcinoma	Substitution - Missense
c.262G>A; p.V88I; 5:113143270-113143270	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1082C>G; p.A361G; 5:113082992-113082992	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1671C>T; p.C557C; 5:113053932-113053932	prostate	carcinoma	Substitution - coding silent
c.172-1G>A; p.?; 5:113143361-113143361	skin	malignant_melanoma	Unknown
c.2422C>T; p.L808F; 5:113027370-113027370	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1581C>T; p.A527A; 5:113064046-113064046	skin	malignant_melanoma	Substitution - coding silent
c.1016C>T; p.S339L; 5:113084150-113084150	skin	malignant_melanoma	Substitution - Missense
c.1016C>T; p.S339L; 5:113084150-113084150	skin	malignant_melanoma	Substitution - Missense
c.204G>A; p.E68E; 5:113143328-113143328	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1870G>A; p.A624T; 5:113053733-113053733	skin	malignant_melanoma	Substitution - Missense
c.318G>A; p.E106E; 5:113122823-113122823	skin	malignant_melanoma	Substitution - coding silent
c.1853T>C; p.L618P; 5:113053750-113053750	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1433G>A; p.R478Q; 5:113068106-113068106	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.473T>G; p.L158R; 5:113104340-113104340	skin	malignant_melanoma	Substitution - Missense
c.1561G>A; p.D521N; 5:113064066-113064066	skin	malignant_melanoma	Substitution - Missense
c.1315G>A; p.E439K; 5:113071134-113071134	skin	malignant_melanoma	Substitution - Missense
c.1888G>T; p.A630S; 5:113049290-113049290	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1134C>T; p.F378F; 5:113082940-113082940	skin	malignant_melanoma	Substitution - coding silent
c.1789C>T; p.P597S; 5:113053814-113053814	skin	malignant_melanoma	Substitution - Missense
c.805G>A; p.E269K; 5:113101762-113101762	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1254C>T; p.T418T; 5:113071195-113071195	skin	malignant_melanoma	Substitution - coding silent
c.410C>T; p.S137F; 5:113122731-113122731	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.875C>T; p.P292L; 5:113085264-113085264	skin	malignant_melanoma	Substitution - Missense
c.1384C>T; p.L462F; 5:113068155-113068155	skin	malignant_melanoma	Substitution - Missense
c.2006C>T; p.S669F; 5:113049172-113049172	skin	malignant_melanoma	Substitution - Missense
c.2228C>T; p.A743V; 5:113029015-113029015	small_intestine	carcinoid-endocrine_tumour	Substitution - Missense
c.2250C>T; p.S750S; 5:113028993-113028993	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1568G>A; p.S523N; 5:113064059-113064059	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1232A>G; p.K411R; 5:113071217-113071217	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1266G>T; p.E422D; 5:113071183-113071183	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.558C>T; p.A186A; 5:113104255-113104255	stomach	adenocarcinoma	Substitution - coding silent
c.1588G>A; p.V530M; 5:113064039-113064039	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.270G>A; p.A90A; 5:113143262-113143262	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2095G>C; p.D699H; 5:113043621-113043621	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1031G>A; p.R344Q; 5:113084135-113084135	stomach	adenocarcinoma	Substitution - Missense
c.1284C>T; p.A428A; 5:113071165-113071165	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1955C>T; p.T652M; 5:113049223-113049223	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2170A>G; p.T724A; 5:113043546-113043546	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.241C>T; p.R81C; 5:113143291-113143291	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1592C>T; p.A531V; 5:113064035-113064035	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.964C>T; p.P322S; 5:113085175-113085175	thyroid	carcinoma	Substitution - Missense
c.1284C>T; p.A428A; 5:113071165-113071165	thyroid	other; neoplasm	Substitution - coding silent
c.2073C>T; p.D691D; 5:113049105-113049105	thyroid	other; neoplasm	Substitution - coding silent
c.113G>A; p.R38H; 5:113151367-113151367	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1084G>A; p.E362K; 5:113082990-113082990	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2361G>A; p.L787L; 5:113027431-113027431	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.835G>A; p.E279K; 5:113085304-113085304	urinary_tract; bladder	carcinoma	Substitution - Missense
c.325G>A; p.E109K; 5:113122816-113122816	urinary_tract; bladder	carcinoma	Substitution - Missense
c.489G>C; p.Q163H; 5:113104324-113104324	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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