Entrez Gene

Basic Information
Gene ID	3036
Name	HAS1
Synonymous	hyaluronan synthase 1;HAS1;hyaluronan synthase 1
Definition	HA synthase 1\|hyaluronate synthase 1\|hyaluronic acid synthase 1
Position	19q13.4
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.377C>A; p.A126E; 19:51719531-51719531	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.658T>C; p.Y220H; 19:51719250-51719250	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	breast	carcinoma	Substitution - Missense
c.1337C>T; p.A446V; 19:51713827-51713827	breast	carcinoma	Substitution - Missense
c.1178G>C; p.W393S; 19:51713986-51713986	breast	carcinoma	Substitution - Missense
c.1111C>T; p.R371W; 19:51714053-51714053	breast	carcinoma	Substitution - Missense
c.915C>T; p.I305I; 19:51716981-51716981	breast	carcinoma	Substitution - coding silent
c.1358G>A; p.R453Q; 19:51713806-51713806	breast	carcinoma	Substitution - Missense
c.766G>A; p.E256K; 19:51717130-51717130	central_nervous_system; brain	glioma	Substitution - Missense
c.703-1G>A; p.?; 19:51717194-51717194	central_nervous_system; brain	glioma	Unknown
c.519G>A; p.A173A; 19:51719389-51719389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.649G>A; p.E217K; 19:51719259-51719259	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.679G>A; p.G227R; 19:51719229-51719229	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1125G>A; p.Q375Q; 19:51714039-51714039	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1024C>A; p.L342I; 19:51716293-51716293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1310G>A; p.C437Y; 19:51713854-51713854	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.929G>T; p.G310V; 19:51716388-51716388	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520G>A; p.A174T; 19:51719388-51719388	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1395G>A; p.A465A; 19:51713769-51713769	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.622G>A; p.V208M; 19:51719286-51719286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.609C>T; p.R203R; 19:51719299-51719299	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - coding silent
c.1358G>A; p.R453Q; 19:51713806-51713806	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.798C>A; p.D266E; 19:51717098-51717098	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.442T>C; p.F148L; 19:51719466-51719466	kidney	other; neoplasm	Substitution - Missense
c.1034G>A; p.R345H; 19:51716283-51716283	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1705C>T; p.R569W; 19:51713459-51713459	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.443T>A; p.F148Y; 19:51719465-51719465	kidney	other; neoplasm	Substitution - Missense
c.1670C>T; p.T557M; 19:51713494-51713494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.639C>T; p.G213G; 19:51719269-51719269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1529C>T; p.A510V; 19:51713635-51713635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>A; p.L321I; 19:51716356-51716356	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1206C>A; p.T402T; 19:51713958-51713958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1139C>A; p.S380Y; 19:51714025-51714025	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1133G>A; p.R378H; 19:51714031-51714031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.609C>T; p.R203R; 19:51719299-51719299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.735G>T; p.M245I; 19:51717161-51717161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1625C>T; p.A542V; 19:51713539-51713539	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.40T>C; p.C14R; 19:51719868-51719868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.18G>A; p.A6A; 19:51719890-51719890	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1280G>A; p.R427H; 19:51713884-51713884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1185C>T; p.H395H; 19:51713979-51713979	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1216G>T; p.V406L; 19:51713948-51713948	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1289C>T; p.A430V; 19:51713875-51713875	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1257G>A; p.V419V; 19:51713907-51713907	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.490G>A; p.G164S; 19:51719418-51719418	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.686C>T; p.S229L; 19:51719222-51719222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.R216C; 19:51719262-51719262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.776G>A; p.R259Q; 19:51717120-51717120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1590C>T; p.S530S; 19:51713574-51713574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1590C>T; p.S530S; 19:51713574-51713574	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1187G>A; p.R396Q; 19:51713977-51713977	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1258C>T; p.L420L; 19:51713906-51713906	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1543G>T; p.G515W; 19:51713621-51713621	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1543G>T; p.G515W; 19:51713621-51713621	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1543G>T; p.G515W; 19:51713621-51713621	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1018C>T; p.R340W; 19:51716299-51716299	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1708C>T; p.R570W; 19:51713456-51713456	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1274C>T; p.A425V; 19:51713890-51713890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1489G>A; p.A497T; 19:51713675-51713675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.812A>G; p.N271S; 19:51717084-51717084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.678C>T; p.L226L; 19:51719230-51719230	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.626C>T; p.A209V; 19:51719282-51719282	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.696C>T; p.Y232Y; 19:51719212-51719212	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1073G>T; p.R358M; 19:51714091-51714091	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.367T>C; p.Y123H; 19:51719541-51719541	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.714G>A; p.S238S; 19:51717182-51717182	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1079G>A; p.R360H; 19:51714085-51714085	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.750C>T; p.L250L; 19:51717146-51717146	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1210G>C; p.E404Q; 19:51713954-51713954	liver	carcinoma	Substitution - Missense
c.1717G>A; p.G573S; 19:51713447-51713447	liver	carcinoma	Substitution - Missense
c.1717G>A; p.G573S; 19:51713447-51713447	liver	carcinoma	Substitution - Missense
c.859G>T; p.V287L; 19:51717037-51717037	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.593C>A; p.A198E; 19:51719315-51719315	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.851G>C; p.R284P; 19:51717045-51717045	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.635G>A; p.W212*; 19:51719273-51719273	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1323G>T; p.V441V; 19:51713841-51713841	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.357C>A; p.R119R; 19:51719551-51719551	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1713C>A; p.T571T; 19:51713451-51713451	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.637G>C; p.G213R; 19:51719271-51719271	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1555C>T; p.R519C; 19:51713609-51713609	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.847C>A; p.L283M; 19:51717049-51717049	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.775C>A; p.R259R; 19:51717121-51717121	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1574C>A; p.A525D; 19:51713590-51713590	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.669C>T; p.F223F; 19:51719239-51719239	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.639C>A; p.G213G; 19:51719269-51719269	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.649G>T; p.E217*; 19:51719259-51719259	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.874G>A; p.E292K; 19:51717022-51717022	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.963T>A; p.L321L; 19:51716354-51716354	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.472G>A; p.A158T; 19:51719436-51719436	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1289C>T; p.A430V; 19:51713875-51713875	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.614G>A; p.C205Y; 19:51719294-51719294	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>A; p.R345H; 19:51716283-51716283	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1561G>A; p.V521I; 19:51713603-51713603	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1076C>T; p.S359F; 19:51714088-51714088	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.674C>T; p.A225V; 19:51719234-51719234	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1394C>T; p.A465V; 19:51713770-51713770	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1691G>A; p.R564Q; 19:51713473-51713473	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1001G>A; p.C334Y; 19:51716316-51716316	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1464G>C; p.W488C; 19:51713700-51713700	pancreas	carcinoma	Substitution - Missense
c.435C>T; p.V145V; 19:51719473-51719473	pancreas	carcinoma	Substitution - coding silent
c.435C>T; p.V145V; 19:51719473-51719473	pancreas	carcinoma	Substitution - coding silent
c.1561G>A; p.V521I; 19:51713603-51713603	pancreas	NS	Substitution - Missense
c.251C>T; p.A84V; 19:51719657-51719657	pancreas	carcinoma	Substitution - Missense
c.489C>T; p.D163D; 19:51719419-51719419	pancreas	carcinoma	Substitution - coding silent
c.1602C>T; p.R534R; 19:51713562-51713562	pancreas	carcinoma	Substitution - coding silent
c.919G>A; p.G307S; 19:51716977-51716977	prostate	carcinoma	Substitution - Missense
c.804G>A; p.R268R; 19:51717092-51717092	skin	malignant_melanoma	Substitution - coding silent
c.1210G>A; p.E404K; 19:51713954-51713954	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1067C>T; p.T356I; 19:51714097-51714097	skin	malignant_melanoma	Substitution - Missense
c.1716G>A; p.G572G; 19:51713448-51713448	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1124A>C; p.Q375P; 19:51714040-51714040	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.987C>T; p.F329F; 19:51716330-51716330	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.582G>C; p.L194L; 19:51719326-51719326	skin	malignant_melanoma	Substitution - coding silent
c.1717G>A; p.G573S; 19:51713447-51713447	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.803G>C; p.R268P; 19:51717093-51717093	skin	malignant_melanoma	Substitution - Missense
c.552G>A; p.R184R; 19:51719356-51719356	skin	malignant_melanoma	Substitution - coding silent
c.351C>T; p.S117S; 19:51719557-51719557	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.785C>T; p.A262V; 19:51717111-51717111	skin	malignant_melanoma	Substitution - Missense
c.1153C>T; p.R385C; 19:51714011-51714011	skin	malignant_melanoma	Substitution - Missense
c.553G>A; p.E185K; 19:51719355-51719355	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.713C>T; p.S238L; 19:51717183-51717183	skin	malignant_melanoma	Substitution - Missense
c.1242C>T; p.F414F; 19:51713922-51713922	skin	malignant_melanoma	Substitution - coding silent
c.1242C>T; p.F414F; 19:51713922-51713922	skin	malignant_melanoma	Substitution - coding silent
c.160C>T; p.L54L; 19:51719748-51719748	skin; leg	malignant_melanoma	Substitution - coding silent
c.990_991GG>AA; p.G331S; 19:51716326-51716327	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.386G>A; p.R129H; 19:51719522-51719522	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1504C>T; p.P502S; 19:51713660-51713660	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1076C>T; p.S359F; 19:51714088-51714088	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.766G>A; p.E256K; 19:51717130-51717130	skin	malignant_melanoma	Substitution - Missense
c.1687G>A; p.V563M; 19:51713477-51713477	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.911G>C; p.C304S; 19:51716985-51716985	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1690C>T; p.R564W; 19:51713474-51713474	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1639G>A; p.A547T; 19:51713525-51713525	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1600C>T; p.R534C; 19:51713564-51713564	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1000T>G; p.C334G; 19:51716317-51716317	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1629G>T; p.A543A; 19:51713535-51713535	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1703G>A; p.R568Q; 19:51713461-51713461	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.627G>T; p.A209A; 19:51719281-51719281	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.40T>C; p.C14R; 19:51719868-51719868	thyroid	other; neoplasm	Substitution - Missense
c.1262G>A; p.R421H; 19:51713902-51713902	thyroid	carcinoma	Substitution - Missense
c.1092G>C; p.E364D; 19:51714072-51714072	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.751G>A; p.V251M; 19:51717145-51717145	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.751G>A; p.V251M; 19:51717145-51717145	urinary_tract; bladder	carcinoma	Substitution - Missense
c.798C>T; p.D266D; 19:51717098-51717098	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.884G>A; p.C295Y; 19:51717012-51717012	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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