ONGene
Top
Scroll To Top
Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

2534

Name

FYN

Synonymous

FYN proto-oncogene, Src family tyrosine kinase;FYN;FYN proto-oncogene, Src family tyrosine kinase

Definition

FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn

Position

6q21

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1483C>T; p.L495L; 6:111661870-111661870

 bone; pelvisEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1050A>G; p.L350L; 6:111694697-111694697

 breastcarcinomaSubstitution - coding silent

c.980T>C; p.V327A; 6:111696339-111696339

 breastcarcinomaSubstitution - Missense

c.870G>A; p.W290*; 6:111696449-111696449

 central_nervous_system; braingliomaSubstitution - Nonsense

c.870G>A; p.W290*; 6:111696449-111696449

 central_nervous_system; braingliomaSubstitution - Nonsense

c.1087A>G; p.K363E; 6:111694660-111694660

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.530A>G; p.E177G; 6:111704016-111704016

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1059C>A; p.F353L; 6:111694688-111694688

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.944C>T; p.A315V; 6:111696375-111696375

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.247G>T; p.G83*; 6:111719805-111719805

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.805G>T; p.E269*; 6:111700161-111700161

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1189C>A; p.L397I; 6:111694459-111694459

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1227C>T; p.F409F; 6:111694421-111694421

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.521T>G; p.L174R; 6:111704025-111704025

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecifiedSubstitution - Missense

c.1591T>C; p.Y531H; 6:111661762-111661762

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecifiedSubstitution - Missense

c.526C>T; p.R176C; 6:111704020-111704020

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecifiedSubstitution - Missense

c.526C>T; p.R176C; 6:111704020-111704020

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecifiedSubstitution - Missense

c.1002T>A; p.S334S; 6:111696317-111696317

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1535C>A; p.T512N; 6:111661818-111661818

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1220C>T; p.A407V; 6:111694428-111694428

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1042+1G>A; p.?; 6:111696276-111696276

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.1042+1G>A; p.?; 6:111696276-111696276

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.60C>T; p.G20G; 6:111719992-111719992

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.328C>A; p.Q110K; 6:111714363-111714363

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.569G>A; p.R190H; 6:111703013-111703013

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.569G>A; p.R190H; 6:111703013-111703013

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.869G>T; p.W290L; 6:111696450-111696450

 large_intestine; rectumNSSubstitution - Missense

c.1514delA; p.K505fs*>33; 6:111661839-111661839

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - Frameshift

c.870G>A; p.W290*; 6:111696449-111696449

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1561G>A; p.E521K; 6:111661792-111661792

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1561G>A; p.E521K; 6:111661792-111661792

 large_intestine; coloncarcinomaSubstitution - Missense

c.1561G>A; p.E521K; 6:111661792-111661792

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.87C>A; p.R29R; 6:111719965-111719965

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1544A>G; p.Y515C; 6:111661809-111661809

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.727G>A; p.V243I; 6:111700239-111700239

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.210G>A; p.S70S; 6:111719842-111719842

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.481C>T; p.R161*; 6:111704065-111704065

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.481C>T; p.R161*; 6:111704065-111704065

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.481C>T; p.R161*; 6:111704065-111704065

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.296A>T; p.D99V; 6:111714395-111714395

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1488T>C; p.H496H; 6:111661865-111661865

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.156C>A; p.N52K; 6:111719896-111719896

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.327T>G; p.F109L; 6:111714364-111714364

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.28G>T; p.E10*; 6:111720024-111720024

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1344C>T; p.D448D; 6:111674560-111674560

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.229C>T; p.R77C; 6:111719823-111719823

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1372G>A; p.E458K; 6:111674532-111674532

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1230A>G; p.G410G; 6:111694418-111694418

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.127G>A; p.G43S; 6:111719925-111719925

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.868T>C; p.W290R; 6:111696451-111696451

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 6:111702966-111702966

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 6:111702966-111702966

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 6:111702966-111702966

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 6:111702966-111702966

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1216A>G; p.I406V; 6:111694432-111694432

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.230G>A; p.R77H; 6:111719822-111719822

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.44C>T; p.T15M; 6:111720008-111720008

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.85C>G; p.R29G; 6:111719967-111719967

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1509G>T; p.W503C; 6:111661844-111661844

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1042+1G>A; p.?; 6:111696276-111696276

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.1042+1G>A; p.?; 6:111696276-111696276

 lungcarcinoma; adenocarcinomaUnknown

c.503A>T; p.N168I; 6:111704043-111704043

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.831G>C; p.L277L; 6:111700135-111700135

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.315A>T; p.K105N; 6:111714376-111714376

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.287G>A; p.R96Q; 6:111714404-111714404

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.684A>T; p.V228V; 6:111702898-111702898

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1286C>T; p.P429L; 6:111674618-111674618

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1377G>T; p.L459L; 6:111674527-111674527

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1003G>C; p.E335Q; 6:111696316-111696316

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.355_356insA; p.W119fs*1; 6:111708009-111708010

 lungcarcinoma; adenocarcinomaInsertion - Frameshift

c.1324A>G; p.R442G; 6:111674580-111674580

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1081G>T; p.A361S; 6:111694666-111694666

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1376T>C; p.L459P; 6:111674528-111674528

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.169G>A; p.G57R; 6:111719883-111719883

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1420G>T; p.E474*; 6:111661933-111661933

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1503C>G; p.H501Q; 6:111661850-111661850

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.727G>C; p.V243L; 6:111700239-111700239

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.727G>C; p.V243L; 6:111700239-111700239

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.727G>C; p.V243L; 6:111700239-111700239

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.727G>C; p.V243L; 6:111700239-111700239

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.233C>T; p.T78M; 6:111719819-111719819

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>A; p.T15T; 6:111720007-111720007

 pancreascarcinomaSubstitution - coding silent

c.45G>A; p.T15T; 6:111720007-111720007

 pancreascarcinoma; ductal_carcinomaSubstitution - coding silent

c.100C>G; p.P34A; 6:111719952-111719952

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.962T>G; p.L321R; 6:111696357-111696357

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1162C>T; p.H388Y; 6:111694486-111694486

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.328C>A; p.Q110K; 6:111714363-111714363

 skinmalignant_melanomaSubstitution - Missense

c.1352C>T; p.S451F; 6:111674552-111674552

 skinmalignant_melanomaSubstitution - Missense

c.1228G>A; p.G410R; 6:111694420-111694420

 skinmalignant_melanomaSubstitution - Missense

c.1228G>A; p.G410R; 6:111694420-111694420

 skinmalignant_melanomaSubstitution - Missense

c.375G>A; p.L125L; 6:111707990-111707990

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1298C>T; p.T433M; 6:111674606-111674606

 skinmalignant_melanomaSubstitution - Missense

c.939G>A; p.E313E; 6:111696380-111696380

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.861G>A; p.M287I; 6:111700105-111700105

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1532C>T; p.P511L; 6:111661821-111661821

 skinmalignant_melanomaSubstitution - Missense

c.292G>A; p.E98K; 6:111714399-111714399

 skinmalignant_melanomaSubstitution - Missense

c.466C>T; p.R156*; 6:111704080-111704080

 skinmalignant_melanomaSubstitution - Nonsense

c.509G>A; p.R170K; 6:111704037-111704037

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>A; p.T15T; 6:111720007-111720007

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.328C>T; p.Q110*; 6:111714363-111714363

 skinmalignant_melanomaSubstitution - Nonsense

c.799C>T; p.P267S; 6:111700167-111700167

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1229G>A; p.G410E; 6:111694419-111694419

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.616C>T; p.R206C; 6:111702966-111702966

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.770C>T; p.S257F; 6:111700196-111700196

 skinmalignant_melanomaSubstitution - Missense

c.46G>A; p.E16K; 6:111720006-111720006

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.652C>T; p.R218W; 6:111702930-111702930

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.388_404del17; p.T130fs*7; 6:111707961-111707977

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.1175G>A; p.R392Q; 6:111694473-111694473

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.514A>G; p.T172A; 6:111704032-111704032

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.252G>A; p.V84V; 6:111714439-111714439

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1283T>G; p.F428C; 6:111674621-111674621

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1394T>C; p.V465A; 6:111674510-111674510

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1156T>C; p.Y386H; 6:111694492-111694492

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1315C>A; p.L439M; 6:111674589-111674589

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1451G>T; p.R484M; 6:111661902-111661902

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.118C>T; p.P40S; 6:111719934-111719934

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 6:111702966-111702966

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.354T>C; p.D118D; 6:111708011-111708011

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1606A>C; p.N536H; 6:111661747-111661747

 thyroidother; neoplasmSubstitution - Missense

c.16T>C; p.C6R; 6:111720036-111720036

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.258C>G; p.L86L; 6:111714433-111714433

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.258C>G; p.L86L; 6:111714433-111714433

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.328C>G; p.Q110E; 6:111714363-111714363

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1479C>T; p.I493I; 6:111661874-111661874

 urinary_tract; bladdercarcinomaSubstitution - coding silent