Entrez Gene

Basic Information
Gene ID	2521
Name	FUS
Synonymous	FUS RNA binding protein;FUS;FUS RNA binding protein
Definition	75 kDa DNA-pairing protein\|RNA-binding protein FUS\|fus-like protein\|fused in sarcoma\|fusion gene in myxoid liposarcoma\|heterogeneous nuclear ribonucleoprotein P2\|oncogene FUS\|oncogene TLS\|translocated in liposarcoma protein
Position	16p11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1163G>A; p.R388Q; 16:31190136-31190136	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.413G>C; p.G138A; 16:31184286-31184286	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.66G>A; p.G22G; 16:31182540-31182540	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1530G>C; p.K510N; 16:31191099-31191099	breast	carcinoma	Substitution - Missense
c.259T>A; p.S87T; 16:31183926-31183926	breast	carcinoma	Substitution - Missense
c.1503_1505delGGA; p.D502delD; 16:31191072-31191074	breast	carcinoma	Deletion - In frame
c.1503_1505delGGA; p.D502delD; 16:31191072-31191074	breast	carcinoma	Deletion - In frame
c.934A>C; p.K312Q; 16:31189224-31189224	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.934A>C; p.K312Q; 16:31189224-31189224	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1157G>A; p.R386Q; 16:31190130-31190130	breast	carcinoma	Substitution - Missense
c.1418G>A; p.R473H; 16:31190987-31190987	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1418G>A; p.R473H; 16:31190987-31190987	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.234T>C; p.T78T; 16:31183901-31183901	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1264C>A; p.R422R; 16:31190370-31190370	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.684C>T; p.G228G; 16:31185099-31185099	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1493G>A; p.R498Q; 16:31191062-31191062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1249G>A; p.G417S; 16:31190355-31190355	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.323G>A; p.S108N; 16:31183990-31183990	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.910T>C; p.Y304H; 16:31189200-31189200	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1289A>C; p.N430T; 16:31190395-31190395	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.630G>T; p.Q210H; 16:31185045-31185045	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.498T>A; p.G166G; 16:31184371-31184371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1080C>A; p.S360S; 16:31190053-31190053	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.135G>A; p.T45T; 16:31182609-31182609	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1136G>C; p.G379A; 16:31190109-31190109	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1342A>T; p.K448*; 16:31190791-31190791	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.640G>A; p.G214R; 16:31185055-31185055	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1438G>A; p.D480N; 16:31191007-31191007	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1340G>T; p.C447F; 16:31190789-31190789	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1339T>G; p.C447G; 16:31190788-31190788	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.136G>C; p.D46H; 16:31182610-31182610	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1197T>C; p.G399G; 16:31190303-31190303	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.147C>A; p.G49G; 16:31182621-31182621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.147C>A; p.G49G; 16:31182621-31182621	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.523+1G>T; p.?; 16:31184397-31184397	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.766G>A; p.G256R; 16:31186803-31186803	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.27_29delAGC; p.A10delA; 16:31182411-31182413	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.592G>T; p.D198Y; 16:31185007-31185007	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1500T>C; p.G500G; 16:31191069-31191069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.G228G; 16:31185099-31185099	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.G228G; 16:31185099-31185099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.G228G; 16:31185099-31185099	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.G228G; 16:31185099-31185099	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.G228G; 16:31185099-31185099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1129C>T; p.R377W; 16:31190102-31190102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.687T>C; p.G229G; 16:31185102-31185102	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.637C>T; p.R213C; 16:31185052-31185052	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1486delG; p.G497fs*>30; 16:31191055-31191055	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1463G>A; p.G488D; 16:31191032-31191032	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1516T>G; p.F506V; 16:31191085-31191085	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>T; p.P431L; 16:31190398-31190398	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.669C>T; p.G223G; 16:31185084-31185084	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.669C>T; p.G223G; 16:31185084-31185084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1348C>T; p.P450S; 16:31190797-31190797	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.451delC; p.P152fs*33; 16:31184324-31184324	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.67C>T; p.Q23*; 16:31182541-31182541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.681C>T; p.G227G; 16:31185096-31185096	liver	carcinoma	Substitution - coding silent
c.681C>T; p.G227G; 16:31185096-31185096	liver	carcinoma	Substitution - coding silent
c.964A>T; p.I322F; 16:31189692-31189692	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.964A>T; p.I322F; 16:31189692-31189692	liver	carcinoma	Substitution - Missense
c.993C>G; p.G331G; 16:31189721-31189721	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.419A>C; p.Q140P; 16:31184292-31184292	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1462G>T; p.G488C; 16:31191031-31191031	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.617G>C; p.G206A; 16:31185032-31185032	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.611G>T; p.G204V; 16:31185026-31185026	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1542G>T; p.R514S; 16:31191399-31191399	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1541G>T; p.R514M; 16:31191398-31191398	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1148G>A; p.R383H; 16:31190121-31190121	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.776G>T; p.R259L; 16:31186813-31186813	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1401C>G; p.N467K; 16:31190970-31190970	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.317C>T; p.P106L; 16:31183984-31183984	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1405G>A; p.G469R; 16:31190974-31190974	oesophagus	carcinoma	Substitution - Missense
c.1013C>T; p.T338M; 16:31189741-31189741	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1539-4T>A; p.?; 16:31191392-31191392	ovary	other; neoplasm	Unknown
c.1539-4T>A; p.?; 16:31191392-31191392	ovary	other; neoplasm	Unknown
c.531T>C; p.Y177Y; 16:31184946-31184946	pancreas	carcinoma	Substitution - coding silent
c.274G>A; p.G92R; 16:31183941-31183941	prostate	carcinoma	Substitution - Missense
c.1111C>T; p.R371C; 16:31190084-31190084	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.237C>T; p.G79G; 16:31183904-31183904	prostate	carcinoma	Substitution - coding silent
c.1462G>A; p.G488S; 16:31191031-31191031	prostate	carcinoma	Substitution - Missense
c.714C>T; p.G238G; 16:31185129-31185129	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1087C>T; p.P363S; 16:31190060-31190060	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1458C>T; p.G486G; 16:31191027-31191027	skin	malignant_melanoma	Substitution - coding silent
c.1077C>T; p.F359F; 16:31190050-31190050	skin	malignant_melanoma	Substitution - coding silent
c.1129C>T; p.R377W; 16:31190102-31190102	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.210A>T; p.S70S; 16:31183877-31183877	skin	malignant_melanoma	Substitution - coding silent
c.786C>T; p.F262F; 16:31186823-31186823	skin	malignant_melanoma	Substitution - coding silent
c.684delC; p.G229fs*93; 16:31185099-31185099	skin	malignant_melanoma	Deletion - Frameshift
c.191-2A>T; p.?; 16:31183856-31183856	skin	malignant_melanoma	Unknown
c.1503G>A; p.G501G; 16:31191072-31191072	skin	malignant_melanoma	Substitution - coding silent
c.861C>T; p.I287I; 16:31189151-31189151	skin	malignant_melanoma	Substitution - coding silent
c.1470C>T; p.D490D; 16:31191039-31191039	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1179C>T; p.G393G; 16:31190285-31190285	skin	malignant_melanoma	Substitution - coding silent
c.846A>G; p.S282S; 16:31189136-31189136	skin	malignant_melanoma	Substitution - coding silent
c.285C>T; p.S95S; 16:31183952-31183952	skin	malignant_melanoma	Substitution - coding silent
c.1446C>T; p.G482G; 16:31191015-31191015	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.339C>T; p.Y113Y; 16:31184212-31184212	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.147C>A; p.G49G; 16:31182621-31182621	thyroid	other; neoplasm	Substitution - coding silent
c.1566G>T; p.R522S; 16:31191423-31191423	thyroid	other; neoplasm	Substitution - Missense
c.800-3A>T; p.?; 16:31188322-31188322	urinary_tract; bladder	carcinoma	Unknown
c.457C>T; p.Q153*; 16:31184330-31184330	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1100C>A; p.S367*; 16:31190073-31190073	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1412A>G; p.D471G; 16:31190981-31190981	urinary_tract; bladder	carcinoma	Substitution - Missense
c.273C>A; p.Y91*; 16:31183940-31183940	urinary_tract; bladder	carcinoma	Substitution - Nonsense

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COSMIC confirmed somatic mutation [Top]

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