Entrez Gene

Basic Information
Gene ID	23512
Name	SUZ12
Synonymous	SUZ12 polycomb repressive complex 2 subunit;SUZ12;SUZ12 polycomb repressive complex 2 subunit
Definition	chET 9 protein\|chromatin precipitated E2F target 9 protein\|joined to JAZF1 protein\|polycomb protein SUZ12\|suppressor of zeste 12 homolog\|suppressor of zeste 12 protein homolog
Position	17q11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1585C>G; p.L529V; 17:31994711-31994711	breast	carcinoma	Substitution - Missense
c.343_346delCTTA; p.Y117fs*24; 17:31940443-31940446	breast	carcinoma	Deletion - Frameshift
c.1147G>A; p.E383K; 17:31988443-31988443	breast	carcinoma	Substitution - Missense
c.338G>A; p.R113K; 17:31940438-31940438	breast	carcinoma	Substitution - Missense
c.955A>C; p.M319L; 17:31983036-31983036	breast	carcinoma	Substitution - Missense
c.2073G>A; p.G691G; 17:31998856-31998856	breast	carcinoma	Substitution - coding silent
c.285G>C; p.Q95H; 17:31940296-31940296	breast	carcinoma	Substitution - Missense
c.432G>C; p.M144I; 17:31947662-31947662	breast	carcinoma	Substitution - Missense
c.2192C>G; p.S731*; 17:31998975-31998975	breast	carcinoma	Substitution - Nonsense
c.856C>T; p.R286*; 17:31976553-31976553	central_nervous_system; brain	glioma	Substitution - Nonsense
c.1794+1G>C; p.?; 17:31995763-31995763	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Unknown
c.1794+1G>C; p.?; 17:31995763-31995763	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Unknown
c.1261G>A; p.E421K; 17:31993301-31993301	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2148_2154delCTCAAAA; p.N716fs*>22; 17:31998931-31998937	central_nervous_system; brain	glioma	Deletion - Frameshift
c.1295T>G; p.F432C; 17:31993866-31993866	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.546T>C; p.V182V; 17:31973186-31973186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.974G>A; p.C325Y; 17:31983055-31983055	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2013A>G; p.I671M; 17:31998796-31998796	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.302G>A; p.R101Q; 17:31940313-31940313	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.343_346delCTTA; p.Y117fs*24; 17:31940443-31940446	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.504T>C; p.N168N; 17:31966195-31966195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1062G>A; p.T354T; 17:31988358-31988358	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1038C>T; p.F346F; 17:31988334-31988334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2044C>T; p.R682C; 17:31998827-31998827	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.426G>T; p.E142D; 17:31947656-31947656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1316G>T; p.R439M; 17:31993887-31993887	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2173G>T; p.D725Y; 17:31998956-31998956	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.646A>C; p.N216H; 17:31975536-31975536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1323A>C; p.Q441H; 17:31993894-31993894	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1993G>T; p.D665Y; 17:31998776-31998776	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.480G>A; p.T160T; 17:31966171-31966171	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.480G>A; p.T160T; 17:31966171-31966171	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.856C>T; p.R286*; 17:31976553-31976553	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Nonsense
c.1377delA; p.K459fs*29; 17:31993948-31993948	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Deletion - Frameshift
c.488G>A; p.G163D; 17:31966179-31966179	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.488G>A; p.G163D; 17:31966179-31966179	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.488G>A; p.G163D; 17:31966179-31966179	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.308G>A; p.R103Q; 17:31940319-31940319	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1146_1147delAG; p.L385fs*10; 17:31988442-31988443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Deletion - Frameshift
c.820A>C; p.I274L; 17:31975710-31975710	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.372_375delAACA; p.N126fs*15; 17:31940472-31940475	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Deletion - Frameshift
c.1814A>T; p.D605V; 17:31996817-31996817	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Missense
c.1692_1704del13; p.Y565fs*13; 17:31995660-31995672	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Deletion - Frameshift
c.1738G>T; p.E580*; 17:31995706-31995706	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Nonsense
c.921_922delCT; p.L308fs*8; 17:31983002-31983003	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Deletion - Frameshift
c.1105_1106insA; p.S369fs*12; 17:31988401-31988402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Insertion - Frameshift
c.1105_1106insA; p.S369fs*12; 17:31988401-31988402	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Insertion - Frameshift
c.153T>G; p.S51R; 17:31937399-31937399	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.283C>A; p.Q95K; 17:31940294-31940294	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.283C>A; p.Q95K; 17:31940294-31940294	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.667A>T; p.K223*; 17:31975557-31975557	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1430A>C; p.N477T; 17:31994001-31994001	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1013T>A; p.L338H; 17:31983094-31983094	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1764T>G; p.D588E; 17:31995732-31995732	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1620G>T; p.M540I; 17:31995588-31995588	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1078C>T; p.R360C; 17:31988374-31988374	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1950G>T; p.K650N; 17:31998733-31998733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1552G>A; p.G518R; 17:31994678-31994678	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.856C>T; p.R286*; 17:31976553-31976553	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2087_2088insA; p.A697fs*7; 17:31998870-31998871	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.301C>T; p.R101*; 17:31940312-31940312	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.767G>A; p.R256H; 17:31975657-31975657	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.308G>A; p.R103Q; 17:31940319-31940319	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1522C>T; p.R508C; 17:31994648-31994648	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1926T>G; p.N642K; 17:31998709-31998709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.920G>A; p.R307H; 17:31983001-31983001	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1702A>G; p.S568G; 17:31995670-31995670	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1702A>G; p.S568G; 17:31995670-31995670	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1702A>G; p.S568G; 17:31995670-31995670	large_intestine; colon	carcinoma	Substitution - Missense
c.1702A>G; p.S568G; 17:31995670-31995670	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1039G>A; p.E347K; 17:31988335-31988335	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1079G>A; p.R360H; 17:31988375-31988375	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1183A>G; p.K395E; 17:31988479-31988479	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.857G>A; p.R286Q; 17:31976554-31976554	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2098G>T; p.E700*; 17:31998881-31998881	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.427A>G; p.K143E; 17:31947657-31947657	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1412A>G; p.H471R; 17:31993983-31993983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.824-1G>T; p.?; 17:31976520-31976520	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.995C>T; p.A332V; 17:31983076-31983076	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1375A>G; p.K459E; 17:31993946-31993946	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1090G>T; p.E364*; 17:31988386-31988386	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1373G>A; p.R458H; 17:31993944-31993944	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2148_2154delCTCAAAA; p.N716fs*>22; 17:31998931-31998937	lung	carcinoma; large_cell_carcinoma	Deletion - Frameshift
c.1993G>A; p.D665N; 17:31998776-31998776	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1742T>A; p.V581E; 17:31995710-31995710	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.184G>C; p.A62P; 17:31937430-31937430	ovary	other; neoplasm	Substitution - Missense
c.1078C>T; p.R360C; 17:31988374-31988374	skin; neck	malignant_melanoma	Substitution - Missense
c.868G>A; p.D290N; 17:31976565-31976565	skin	malignant_melanoma	Substitution - Missense
c.2043C>T; p.L681L; 17:31998826-31998826	skin	malignant_melanoma	Substitution - coding silent
c.1047T>A; p.F349L; 17:31988343-31988343	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55G>A; p.G19R; 17:31937301-31937301	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.681C>T; p.F227F; 17:31975571-31975571	skin	malignant_melanoma	Substitution - coding silent
c.1825G>A; p.G609R; 17:31996828-31996828	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.161_163delCCT; p.S59delS; 17:31937407-31937409	skin	malignant_melanoma	Deletion - In frame
c.2166G>A; p.L722L; 17:31998949-31998949	skin	malignant_melanoma	Substitution - coding silent
c.1284A>G; p.I428M; 17:31993324-31993324	skin; extremity	malignant_melanoma	Substitution - Missense
c.698C>T; p.S233F; 17:31975588-31975588	skin	malignant_melanoma	Substitution - Missense
c.1875-1G>T; p.?; 17:31998657-31998657	skin	malignant_melanoma	Unknown
c.825T>A; p.D275E; 17:31976522-31976522	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1268G>A; p.R423Q; 17:31993308-31993308	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1202-3C>A; p.?; 17:31993239-31993239	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.619C>T; p.P207S; 17:31975509-31975509	skin	malignant_melanoma	Substitution - Missense
c.1723C>T; p.R575C; 17:31995691-31995691	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.212T>C; p.V71A; 17:31937458-31937458	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.994G>A; p.A332T; 17:31983075-31983075	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.857G>A; p.R286Q; 17:31976554-31976554	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1648G>A; p.E550K; 17:31995616-31995616	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1886A>T; p.D629V; 17:31998669-31998669	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1129C>T; p.L377F; 17:31988425-31988425	urinary_tract; bladder	carcinoma	Substitution - Missense
c.992G>A; p.R331K; 17:31983073-31983073	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.992G>A; p.R331K; 17:31983073-31983073	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1801G>C; p.E601Q; 17:31996804-31996804	urinary_tract; bladder	carcinoma	Substitution - Missense
c.795G>A; p.M265I; 17:31975685-31975685	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1811C>G; p.S604C; 17:31996814-31996814	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

Bioinformatics and cancer genomics links

Bioinformatics centers

Bioinformatics centers

Welcome to Bioinfo-MinZhao!