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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

23411

Name

SIRT1

Synonymous

sirtuin 1;SIRT1;sirtuin 1

Definition

NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1

Position

10q21.3

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1906C>T; p.R636W; 10:67913022-67913022

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1852G>A; p.G618R; 10:67912968-67912968

 breastcarcinomaSubstitution - Missense

c.2043G>C; p.Q681H; 10:67916392-67916392

 breastcarcinomaSubstitution - Missense

c.1441G>A; p.D481N; 10:67912557-67912557

 breastcarcinomaSubstitution - Missense

c.1945C>T; p.R649C; 10:67916294-67916294

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.1945C>T; p.R649C; 10:67916294-67916294

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.845G>A; p.R282H; 10:67891457-67891457

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2188G>T; p.A730S; 10:67916537-67916537

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1558G>T; p.E520*; 10:67912674-67912674

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1399G>T; p.E467*; 10:67912515-67912515

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1423G>T; p.D475Y; 10:67912539-67912539

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2094C>T; p.F698F; 10:67916443-67916443

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1208C>T; p.P403L; 10:67909293-67909293

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1260A>G; p.E420E; 10:67909345-67909345

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.994T>C; p.L332L; 10:67906841-67906841

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.2135C>A; p.A712D; 10:67916484-67916484

 kidneyother; neoplasmSubstitution - Missense

c.877C>T; p.P293S; 10:67891489-67891489

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.874G>T; p.D292Y; 10:67891486-67891486

 kidneyother; neoplasmSubstitution - Missense

c.876T>A; p.D292E; 10:67891488-67891488

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.760delA; p.I256fs*2; 10:67889094-67889094

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.760delA; p.I256fs*2; 10:67889094-67889094

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.341C>A; p.P114Q; 10:67885062-67885062

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1021C>T; p.R341C; 10:67906868-67906868

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1282T>C; p.Y428H; 10:67909367-67909367

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1220T>C; p.M407T; 10:67909305-67909305

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1220T>C; p.M407T; 10:67909305-67909305

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.845G>A; p.R282H; 10:67891457-67891457

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1147G>A; p.V383I; 10:67908102-67908102

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.306C>T; p.D102D; 10:67885027-67885027

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1558G>T; p.E520*; 10:67912674-67912674

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1558G>T; p.E520*; 10:67912674-67912674

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1105G>A; p.A369T; 10:67908060-67908060

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2227C>T; p.P743S; 10:67916576-67916576

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1289A>C; p.K430T; 10:67909374-67909374

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1628G>T; p.R543I; 10:67912744-67912744

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.408G>A; p.A136A; 10:67885129-67885129

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1209G>A; p.P403P; 10:67909294-67909294

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.444C>T; p.F148F; 10:67887430-67887430

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.943G>T; p.E315*; 10:67906790-67906790

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.2059G>A; p.E687K; 10:67916408-67916408

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2059G>A; p.E687K; 10:67916408-67916408

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1236_1237insT; p.G415fs*2; 10:67909321-67909322

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1236_1237insT; p.G415fs*2; 10:67909321-67909322

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1547G>A; p.R516Q; 10:67912663-67912663

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1547G>A; p.R516Q; 10:67912663-67912663

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1150C>T; p.R384*; 10:67908105-67908105

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1850C>T; p.A617V; 10:67912966-67912966

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2024G>A; p.S675N; 10:67916373-67916373

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1447G>T; p.D483Y; 10:67912563-67912563

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1646C>G; p.S549C; 10:67912762-67912762

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.892G>C; p.D298H; 10:67891504-67891504

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.770T>G; p.I257R; 10:67889104-67889104

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.547+1G>A; p.?; 10:67887534-67887534

 lungcarcinoma; adenocarcinomaUnknown

c.1646C>T; p.S549F; 10:67912762-67912762

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.844C>A; p.R282S; 10:67891456-67891456

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.963C>T; p.F321F; 10:67906810-67906810

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.2199G>A; p.V733V; 10:67916548-67916548

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.686C>T; p.S229L; 10:67889020-67889020

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1208C>G; p.P403R; 10:67909293-67909293

 ovaryother; neoplasmSubstitution - Missense

c.477C>T; p.S159S; 10:67887463-67887463

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1095C>A; p.S365S; 10:67908050-67908050

 pancreascarcinomaSubstitution - coding silent

c.682C>A; p.L228I; 10:67889016-67889016

 pancreascarcinomaSubstitution - Missense

c.2018G>A; p.S673N; 10:67916367-67916367

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1021C>T; p.R341C; 10:67906868-67906868

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1891G>A; p.E631K; 10:67913007-67913007

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.942G>A; p.K314K; 10:67891554-67891554

 skinmalignant_melanomaSubstitution - coding silent

c.1242T>C; p.F414F; 10:67909327-67909327

 skinmalignant_melanomaSubstitution - coding silent

c.1015C>T; p.L339L; 10:67906862-67906862

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.987C>T; p.F329F; 10:67906834-67906834

 skinmalignant_melanomaSubstitution - coding silent

c.596G>A; p.R199Q; 10:67888930-67888930

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1828delA; p.N611fs*10; 10:67912944-67912944

 stomachadenocarcinomaDeletion - Frameshift

c.1546C>T; p.R516*; 10:67912662-67912662

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.504C>A; p.A168A; 10:67887490-67887490

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1752T>G; p.T584T; 10:67912868-67912868

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1339C>T; p.P447S; 10:67909424-67909424

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1319G>A; p.G440E; 10:67909404-67909404

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2005A>G; p.S669G; 10:67916354-67916354

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.214G>T; p.A72S; 10:67884935-67884935

 thyroidother; neoplasmSubstitution - Missense

c.620C>T; p.P207L; 10:67888954-67888954

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1411C>T; p.H471Y; 10:67912527-67912527

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.476C>T; p.S159F; 10:67887462-67887462

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.476C>T; p.S159F; 10:67887462-67887462

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1278G>T; p.M426I; 10:67909363-67909363

 urinary_tract; bladdercarcinomaSubstitution - Missense