Entrez Gene

Basic Information
Gene ID	23326
Name	USP22
Synonymous	ubiquitin specific peptidase 22;USP22;ubiquitin specific peptidase 22
Definition	deubiquitinating enzyme 22\|ubiquitin carboxyl-terminal hydrolase 22\|ubiquitin specific protease 22\|ubiquitin thioesterase 22\|ubiquitin thiolesterase 22\|ubiquitin-specific processing protease 22\|ubiquitin-specific-processing protease 22
Position	17p11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.845C>T; p.S282F; 17:21028667-21028667	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1510G>A; p.D504N; 17:21012930-21012930	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1400T>C; p.L467P; 17:21015856-21015856	breast	carcinoma	Substitution - Missense
c.1289G>A; p.R430K; 17:21018009-21018009	breast	carcinoma	Substitution - Missense
c.1295G>A; p.R432H; 17:21018003-21018003	breast	carcinoma	Substitution - Missense
c.1063C>A; p.R355R; 17:21021134-21021134	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.848G>A; p.C283Y; 17:21028664-21028664	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1494A>G; p.R498R; 17:21015762-21015762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.948G>A; p.A316A; 17:21028564-21028564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.948G>A; p.A316A; 17:21028564-21028564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2239delG; p.E747fs?; 17:21003036-21003036	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1876G>A; p.V626I; 17:21007890-21007890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1755G>A; p.T585T; 17:21011165-21011165	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1193G>A; p.R398H; 17:21018105-21018105	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1837G>A; p.E613K; 17:21007929-21007929	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2152G>A; p.D718N; 17:21004251-21004251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1926G>A; p.R642R; 17:21006958-21006958	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1194T>C; p.R398R; 17:21018104-21018104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1372C>A; p.R458R; 17:21015884-21015884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1264C>A; p.L422M; 17:21018034-21018034	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1766G>C; p.R589P; 17:21011154-21011154	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1754C>T; p.T585M; 17:21011166-21011166	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1064G>A; p.R355Q; 17:21021133-21021133	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1896+10C>A; p.?; 17:21007860-21007860	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1607G>C; p.C536S; 17:21012833-21012833	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.2103C>G; p.H701Q; 17:21004300-21004300	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.2103C>G; p.H701Q; 17:21004300-21004300	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.2103C>G; p.H701Q; 17:21004300-21004300	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1875C>A; p.I625I; 17:21007891-21007891	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.945T>C; p.H315H; 17:21028567-21028567	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1574G>A; p.G525D; 17:21012866-21012866	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1129C>A; p.L377I; 17:21019141-21019141	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1814G>A; p.C605Y; 17:21007952-21007952	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1188T>C; p.G396G; 17:21018110-21018110	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2019G>A; p.Q673Q; 17:21004960-21004960	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1095G>T; p.E365D; 17:21019175-21019175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1922G>A; p.R641Q; 17:21006962-21006962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.868G>A; p.V290I; 17:21028644-21028644	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.882delG; p.R294fs*34; 17:21028630-21028630	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1829G>C; p.S610T; 17:21007937-21007937	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1741A>G; p.T581A; 17:21011179-21011179	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1471G>A; p.A491T; 17:21015785-21015785	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.769A>G; p.K257E; 17:21042733-21042733	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1294C>T; p.R432C; 17:21018004-21018004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1257G>A; p.T419T; 17:21018041-21018041	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1257G>A; p.T419T; 17:21018041-21018041	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1172C>T; p.S391L; 17:21019098-21019098	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1436G>C; p.G479A; 17:21015820-21015820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.877A>G; p.N293D; 17:21028635-21028635	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1064G>A; p.R355Q; 17:21021133-21021133	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1929G>T; p.K643N; 17:21006955-21006955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1875C>A; p.I625I; 17:21007891-21007891	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1367G>T; p.G456V; 17:21015889-21015889	liver	carcinoma	Substitution - Missense
c.2078A>G; p.H693R; 17:21004325-21004325	liver	carcinoma	Substitution - Missense
c.1339T>C; p.S447P; 17:21017959-21017959	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1594A>C; p.T532P; 17:21012846-21012846	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1594A>C; p.T532P; 17:21012846-21012846	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1167C>T; p.I389I; 17:21019103-21019103	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.667A>T; p.M223L; 17:21042835-21042835	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1097A>G; p.K366R; 17:21019173-21019173	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1399C>T; p.L467L; 17:21015857-21015857	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2197G>T; p.E733*; 17:21004206-21004206	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1710C>G; p.N570K; 17:21011210-21011210	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1042A>G; p.I348V; 17:21021155-21021155	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2027C>T; p.T676M; 17:21004952-21004952	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1686_1687delCC; p.L563fs*47; 17:21011233-21011234	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.848G>A; p.C283Y; 17:21028664-21028664	pancreas	carcinoma	Substitution - Missense
c.848G>A; p.C283Y; 17:21028664-21028664	pancreas	carcinoma	Substitution - Missense
c.848G>A; p.C283Y; 17:21028664-21028664	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2184C>T; p.D728D; 17:21004219-21004219	pancreas	carcinoma	Substitution - coding silent
c.743T>C; p.L248P; 17:21042759-21042759	pancreas	carcinoma	Substitution - Missense
c.1935C>T; p.T645T; 17:21006949-21006949	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1403A>G; p.H468R; 17:21015853-21015853	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1676C>T; p.P559L; 17:21011244-21011244	skin	malignant_melanoma	Substitution - Missense
c.1771T>C; p.F591L; 17:21007995-21007995	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1278C>T; p.F426F; 17:21018020-21018020	skin	malignant_melanoma	Substitution - coding silent
c.1193G>T; p.R398L; 17:21018105-21018105	skin	malignant_melanoma	Substitution - Missense
c.1236C>T; p.I412I; 17:21018062-21018062	skin	malignant_melanoma	Substitution - coding silent
c.1467C>T; p.L489L; 17:21015789-21015789	skin	malignant_melanoma	Substitution - coding silent
c.2229C>T; p.F743F; 17:21003046-21003046	skin	malignant_melanoma	Substitution - coding silent
c.2118C>T; p.I706I; 17:21004285-21004285	skin	malignant_melanoma	Substitution - coding silent
c.1236C>T; p.I412I; 17:21018062-21018062	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2110A>C; p.S704R; 17:21004293-21004293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1192C>T; p.R398C; 17:21018106-21018106	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1268G>A; p.R423Q; 17:21018030-21018030	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1124G>A; p.R375Q; 17:21019146-21019146	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1800C>T; p.S600S; 17:21007966-21007966	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1536_1537insC; p.N513fs*98; 17:21012903-21012904	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.1305G>A; p.M435I; 17:21017993-21017993	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1187G>A; p.G396D; 17:21018111-21018111	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1895A>G; p.K632R; 17:21007871-21007871	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1895A>G; p.K632R; 17:21007871-21007871	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1783G>T; p.E595*; 17:21007983-21007983	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.1783G>T; p.E595*; 17:21007983-21007983	urinary_tract; bladder	carcinoma	Substitution - Nonsense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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