Entrez Gene

Basic Information
Gene ID	2268
Name	FGR
Synonymous	FGR proto-oncogene, Src family tyrosine kinase;FGR;FGR proto-oncogene, Src family tyrosine kinase
Definition	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog\|c-fgr protooncogene\|c-src-2 proto-oncogene\|feline Gardner-Rasheed sarcoma viral oncogene homolog\|p55-c-fgr protein\|proto-oncogene c-Fgr\|proto-oncogene tyrosine-protein kinase FGR\|tyrosine-prote
Position	1p36.2-p36.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.711C>T; p.L237L; 1:27615816-27615816	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1348G>A; p.E450K; 1:27613252-27613252	breast	carcinoma	Substitution - Missense
c.1412T>G; p.V471G; 1:27613092-27613092	breast	carcinoma	Substitution - Missense
c.511C>T; p.R171W; 1:27617214-27617214	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.781A>G; p.S261G; 1:27615746-27615746	breast	carcinoma	Substitution - Missense
c.648C>T; p.F216F; 1:27616891-27616891	central_nervous_system; brain	glioma	Substitution - coding silent
c.737C>T; p.P246L; 1:27615790-27615790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1497G>A; p.P499P; 1:27613007-27613007	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.268G>A; p.A90T; 1:27623103-27623103	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.619G>A; p.G207S; 1:27616920-27616920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1130A>G; p.N377S; 1:27614549-27614549	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.417C>T; p.I139I; 1:27621570-27621570	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1448G>A; p.C483Y; 1:27613056-27613056	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.894G>C; p.M298I; 1:27615558-27615558	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1481C>T; p.T494I; 1:27613023-27613023	kidney	other; neoplasm	Substitution - Missense
c.1481C>T; p.T494I; 1:27613023-27613023	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.605A>T; p.K202I; 1:27616934-27616934	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1098A>G; p.V366V; 1:27614581-27614581	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1487G>A; p.R496H; 1:27613017-27613017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.33G>A; p.P11P; 1:27623884-27623884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1512C>A; p.T504T; 1:27612992-27612992	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.970G>A; p.V324M; 1:27615482-27615482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.800G>A; p.R267H; 1:27615727-27615727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.263A>G; p.Y88C; 1:27623108-27623108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.31C>T; p.P11S; 1:27623886-27623886	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.576C>T; p.G192G; 1:27616963-27616963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1486C>T; p.R496C; 1:27613018-27613018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.333A>C; p.E111D; 1:27621654-27621654	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.805C>A; p.L269M; 1:27615722-27615722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>T; p.T297I; 1:27615562-27615562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1273A>G; p.T425A; 1:27613327-27613327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.51G>A; p.E17E; 1:27623866-27623866	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.76A>G; p.R26G; 1:27623841-27623841	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1561C>A; p.P521T; 1:27612943-27612943	liver	carcinoma	Substitution - Missense
c.228G>T; p.G76G; 1:27623143-27623143	liver	carcinoma	Substitution - coding silent
c.228G>T; p.G76G; 1:27623143-27623143	liver	carcinoma	Substitution - coding silent
c.1152G>A; p.R384R; 1:27614527-27614527	liver	carcinoma	Substitution - coding silent
c.846G>A; p.W282*; 1:27615606-27615606	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.979G>C; p.E327Q; 1:27615473-27615473	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.532G>T; p.G178C; 1:27617193-27617193	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.945C>T; p.H315H; 1:27615507-27615507	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.967G>A; p.A323T; 1:27615485-27615485	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1383C>T; p.G461G; 1:27613121-27613121	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.228G>A; p.G76G; 1:27623143-27623143	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1396G>A; p.E466K; 1:27613108-27613108	NS	malignant_melanoma	Substitution - Missense
c.867G>A; p.A289A; 1:27615585-27615585	oesophagus	carcinoma	Substitution - coding silent
c.791C>T; p.T264M; 1:27615736-27615736	oesophagus	carcinoma	Substitution - Missense
c.941G>A; p.R314Q; 1:27615511-27615511	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.924G>A; p.Q308Q; 1:27615528-27615528	pancreas	carcinoma	Substitution - coding silent
c.1141C>T; p.R381C; 1:27614538-27614538	pancreas	carcinoma	Substitution - Missense
c.898C>A; p.P300T; 1:27615554-27615554	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1017C>T; p.H339H; 1:27615435-27615435	prostate	carcinoma	Substitution - coding silent
c.1425C>T; p.Y475Y; 1:27613079-27613079	skin	malignant_melanoma	Substitution - coding silent
c.1425C>T; p.Y475Y; 1:27613079-27613079	skin	malignant_melanoma	Substitution - coding silent
c.49G>A; p.E17K; 1:27623868-27623868	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.846G>A; p.W282*; 1:27615606-27615606	skin	malignant_melanoma	Substitution - Nonsense
c.440G>A; p.G147E; 1:27617285-27617285	skin	malignant_melanoma	Substitution - Missense
c.577G>A; p.D193N; 1:27616962-27616962	skin	malignant_melanoma	Substitution - Missense
c.891C>T; p.T297T; 1:27615561-27615561	skin; arm	malignant_melanoma	Substitution - coding silent
c.1579G>A; p.D527N; 1:27612925-27612925	skin	malignant_melanoma	Substitution - Missense
c.824G>A; p.G275E; 1:27615703-27615703	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.237G>A; p.V79V; 1:27623134-27623134	skin	malignant_melanoma	Substitution - coding silent
c.272G>A; p.R91Q; 1:27623099-27623099	skin	malignant_melanoma	Substitution - Missense
c.107C>T; p.P36L; 1:27623810-27623810	skin	malignant_melanoma	Substitution - Missense
c.1262C>T; p.P421L; 1:27613338-27613338	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.496G>A; p.G166R; 1:27617229-27617229	skin	malignant_melanoma	Substitution - Missense
c.885G>A; p.P295P; 1:27615567-27615567	skin	malignant_melanoma	Substitution - coding silent
c.1357A>C; p.T453P; 1:27613243-27613243	skin	malignant_melanoma	Substitution - Missense
c.1357A>C; p.T453P; 1:27613243-27613243	skin	malignant_melanoma	Substitution - Missense
c.514G>A; p.E172K; 1:27617211-27617211	skin	malignant_melanoma	Substitution - Missense
c.1469C>T; p.A490V; 1:27613035-27613035	skin	malignant_melanoma	Substitution - Missense
c.252C>T; p.A84A; 1:27623119-27623119	skin	malignant_melanoma	Substitution - coding silent
c.916G>A; p.E306K; 1:27615536-27615536	skin	malignant_melanoma	Substitution - Missense
c.417C>T; p.I139I; 1:27621570-27621570	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.346G>A; p.E116K; 1:27621641-27621641	skin	malignant_melanoma	Substitution - Missense
c.1554C>T; p.S518S; 1:27612950-27612950	skin	malignant_melanoma	Substitution - coding silent
c.1285G>A; p.A429T; 1:27613315-27613315	skin	malignant_melanoma	Substitution - Missense
c.228G>A; p.G76G; 1:27623143-27623143	skin	malignant_melanoma	Substitution - coding silent
c.667G>A; p.V223M; 1:27616872-27616872	skin; extremity	malignant_melanoma	Substitution - Missense
c.242T>G; p.L81R; 1:27623129-27623129	skin	malignant_melanoma	Substitution - Missense
c.1146C>T; p.D382D; 1:27614533-27614533	skin	malignant_melanoma	Substitution - coding silent
c.1362G>A; p.K454K; 1:27613238-27613238	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.305A>T; p.E102V; 1:27623066-27623066	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1539G>T; p.E513D; 1:27612965-27612965	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1487G>A; p.R496H; 1:27613017-27613017	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.653C>T; p.S218L; 1:27616886-27616886	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1575C>T; p.P525P; 1:27612929-27612929	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.329+1G>A; p.?; 1:27623041-27623041	stomach	carcinoma; adenocarcinoma	Unknown
c.601C>T; p.R201C; 1:27616938-27616938	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>A; p.K100K; 1:27623071-27623071	thyroid	carcinoma	Substitution - coding silent
c.49G>T; p.E17*; 1:27623868-27623868	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.358C>G; p.L120V; 1:27621629-27621629	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.358C>G; p.L120V; 1:27621629-27621629	urinary_tract; bladder	carcinoma	Substitution - Missense
c.314A>G; p.H105R; 1:27623057-27623057	urinary_tract; bladder	carcinoma	Substitution - Missense
c.572G>C; p.R191T; 1:27616967-27616967	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1062G>C; p.L354F; 1:27614883-27614883	urinary_tract; bladder	carcinoma	Substitution - Missense
c.85G>A; p.G29R; 1:27623832-27623832	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1515C>G; p.F505L; 1:27612989-27612989	urinary_tract; bladder	carcinoma	Substitution - Missense
c.346G>A; p.E116K; 1:27621641-27621641	urinary_tract; bladder	carcinoma	Substitution - Missense
c.77G>T; p.R26I; 1:27623840-27623840	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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