Entrez Gene

Basic Information
Gene ID	2224
Name	FDPS
Synonymous	farnesyl diphosphate synthase;FDPS;farnesyl diphosphate synthase
Definition	(2E,6E)-farnesyl diphosphate synthase\|FPP synthase\|FPP synthetase\|dimethylallyltranstransferase\|farnesyl pyrophosphate synthase\|farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase\|geranyltranstransferase
Position	1q22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.608C>T; p.A203V; 1:155318215-155318215	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1182C>G; p.L394L; 1:155320531-155320531	breast	carcinoma	Substitution - coding silent
c.1137G>A; p.V379V; 1:155320486-155320486	breast	carcinoma	Substitution - coding silent
c.458C>A; p.T153N; 1:155312373-155312373	breast	carcinoma	Substitution - Missense
c.1140C>T; p.F380F; 1:155320489-155320489	breast	carcinoma	Substitution - coding silent
c.1036C>G; p.P346A; 1:155319905-155319905	breast	carcinoma	Substitution - Missense
c.532C>T; p.R178C; 1:155317992-155317992	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.532C>T; p.R178C; 1:155317992-155317992	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.635A>G; p.Y212C; 1:155318242-155318242	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.294G>C; p.E98D; 1:155310160-155310160	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.590A>G; p.D197G; 1:155318197-155318197	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.670G>A; p.E224K; 1:155318277-155318277	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.718G>T; p.D240Y; 1:155318698-155318698	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.181C>A; p.L61I; 1:155310047-155310047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.537G>T; p.R179R; 1:155317997-155317997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.213G>T; p.Q71H; 1:155310079-155310079	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.816C>G; p.F272L; 1:155318898-155318898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1073_1075delAGA; p.K359delK; 1:155320422-155320424	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1216G>A; p.V406I; 1:155320565-155320565	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1075_1077delAAG; p.K359delK; 1:155320424-155320426	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Deletion - In frame
c.156A>G; p.Q52Q; 1:155309945-155309945	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.968A>C; p.K323T; 1:155319837-155319837	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1198G>A; p.A400T; 1:155320547-155320547	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.463G>A; p.G155S; 1:155312378-155312378	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.159G>T; p.A53A; 1:155309948-155309948	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.698C>G; p.T233S; 1:155318678-155318678	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.963C>T; p.T321T; 1:155319832-155319832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.64delC; p.R23fs*45; 1:155309853-155309853	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1196C>T; p.A399V; 1:155320545-155320545	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.465C>T; p.G155G; 1:155312380-155312380	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1166G>A; p.S389N; 1:155320515-155320515	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.26C>T; p.S9F; 1:155309815-155309815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.395T>A; p.V132E; 1:155312310-155312310	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1132G>A; p.A378T; 1:155320481-155320481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.289G>C; p.D97H; 1:155310155-155310155	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>A; p.E56K; 1:155309955-155309955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.213G>T; p.Q71H; 1:155310079-155310079	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.288G>A; p.E96E; 1:155310154-155310154	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.969A>C; p.K323N; 1:155319838-155319838	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.999C>T; p.C333C; 1:155319868-155319868	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.963C>T; p.T321T; 1:155319832-155319832	liver	carcinoma	Substitution - coding silent
c.861C>T; p.G287G; 1:155319625-155319625	liver	carcinoma	Substitution - coding silent
c.71A>T; p.E24V; 1:155309860-155309860	liver	carcinoma	Substitution - Missense
c.71A>T; p.E24V; 1:155309860-155309860	liver	carcinoma	Substitution - Missense
c.1232C>T; p.A411V; 1:155320581-155320581	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.633C>G; p.L211L; 1:155318240-155318240	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1082C>A; p.A361D; 1:155320431-155320431	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.964G>C; p.G322R; 1:155319833-155319833	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.794A>T; p.Y265F; 1:155318876-155318876	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.501G>A; p.V167V; 1:155317961-155317961	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.615C>T; p.I205I; 1:155318222-155318222	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186G>A; p.E396K; 1:155320535-155320535	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.456G>T; p.W152C; 1:155312371-155312371	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.69G>T; p.R23R; 1:155309858-155309858	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.691T>G; p.Y231D; 1:155318671-155318671	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.689C>T; p.S230F; 1:155318669-155318669	ovary	other; neoplasm	Substitution - Missense
c.160T>G; p.W54G; 1:155309949-155309949	ovary	other; neoplasm	Substitution - Missense
c.160T>G; p.W54G; 1:155309949-155309949	ovary	other; neoplasm	Substitution - Missense
c.568G>A; p.V190M; 1:155318175-155318175	pancreas	carcinoma	Substitution - Missense
c.486A>G; p.Q162Q; 1:155317946-155317946	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.371A>G; p.Y124C; 1:155312286-155312286	prostate	carcinoma	Substitution - Missense
c.898G>A; p.E300K; 1:155319662-155319662	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.813_815delCTT; p.F272delF; 1:155318895-155318897	skin; mucosal	malignant_melanoma	Deletion - In frame
c.249C>T; p.F83F; 1:155310115-155310115	skin	malignant_melanoma	Substitution - coding silent
c.263C>T; p.S88F; 1:155310129-155310129	skin	malignant_melanoma	Substitution - Missense
c.72G>C; p.E24D; 1:155309861-155309861	skin	malignant_melanoma	Substitution - Missense
c.1234C>T; p.R412C; 1:155320583-155320583	skin	malignant_melanoma	Substitution - Missense
c.1243T>C; p.Y415H; 1:155320592-155320592	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.449G>A; p.R150Q; 1:155312364-155312364	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.568G>A; p.V190M; 1:155318175-155318175	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.518A>C; p.D173A; 1:155317978-155317978	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.670G>A; p.E224K; 1:155318277-155318277	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1192T>C; p.Y398H; 1:155320541-155320541	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.874G>A; p.A292T; 1:155319638-155319638	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.149G>T; p.W50L; 1:155309938-155309938	thyroid	other; neoplasm	Substitution - Missense
c.912C>G; p.F304L; 1:155319676-155319676	urinary_tract; bladder	carcinoma	Substitution - Missense
c.912C>G; p.F304L; 1:155319676-155319676	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.823C>G; p.P275A; 1:155318905-155318905	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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