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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

208

Name

AKT2

Synonymous

v-akt murine thymoma viral oncogene homolog 2;AKT2;v-akt murine thymoma viral oncogene homolog 2

Definition

PKB beta|RAC-PK-beta|RAC-beta serine/threonine-protein kinase|murine thymoma viral (v-akt) homolog-2|protein kinase Akt-2|protein kinase B beta|rac protein kinase beta

Position

19q13.1-q13.2

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.49G>A; p.E17K; 19:40257052-40257052

 breastcarcinomaSubstitution - Missense

c.1000T>G; p.W334G; 19:40236065-40236065

 breastcarcinomaSubstitution - Missense

c.867C>G; p.I289M; 19:40236350-40236350

 breastcarcinomaSubstitution - Missense

c.999G>A; p.W333*; 19:40236066-40236066

 breastcarcinomaSubstitution - Nonsense

c.252C>T; p.I84I; 19:40255193-40255193

 breastcarcinomaSubstitution - coding silent

c.1066G>A; p.E356K; 19:40235999-40235999

 breastcarcinomaSubstitution - Missense

c.36C>T; p.L12L; 19:40265232-40265232

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1103G>A; p.R368H; 19:40235962-40235962

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.157A>C; p.N53H; 19:40256944-40256944

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1030A>G; p.M344V; 19:40236035-40236035

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.417G>A; p.A139A; 19:40242558-40242558

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.508C>T; p.R170W; 19:40242003-40242003

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.430C>T; p.R144W; 19:40242545-40242545

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.396G>A; p.T132T; 19:40242579-40242579

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.206G>A; p.R69Q; 19:40255239-40255239

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1011T>G; p.G337G; 19:40236054-40236054

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1273C>T; p.P425S; 19:40235138-40235138

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.971A>G; p.D324G; 19:40236094-40236094

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.408G>A; p.M136I; 19:40242567-40242567

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.970G>C; p.D324H; 19:40236095-40236095

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1285C>G; p.Q429E; 19:40235126-40235126

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.686T>C; p.M229T; 19:40238927-40238927

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1320T>A; p.D440E; 19:40235091-40235091

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1318G>A; p.D440N; 19:40235093-40235093

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.783G>A; p.S261S; 19:40238017-40238017

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.751C>T; p.R251W; 19:40238049-40238049

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.782C>T; p.S261L; 19:40238018-40238018

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.669C>T; p.D223D; 19:40238944-40238944

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.47-1G>A; p.?; 19:40257055-40257055

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.583G>A; p.A195T; 19:40240101-40240101

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1189C>T; p.P397S; 19:40235337-40235337

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.221T>C; p.V74A; 19:40255224-40255224

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1402A>T; p.T468S; 19:40233916-40233916

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.517G>A; p.A173T; 19:40241994-40241994

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.431G>A; p.R144Q; 19:40242544-40242544

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1324G>T; p.E442*; 19:40235087-40235087

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.204G>A; p.P68P; 19:40255241-40255241

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.204G>A; p.P68P; 19:40255241-40255241

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1035C>T; p.C345C; 19:40236030-40236030

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.416C>T; p.A139V; 19:40242559-40242559

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.401A>G; p.E134G; 19:40242574-40242574

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1102C>T; p.R368C; 19:40235963-40235963

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1111C>T; p.R371C; 19:40235954-40235954

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1111C>T; p.R371C; 19:40235954-40235954

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.456C>T; p.F152F; 19:40242055-40242055

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.711G>C; p.L237L; 19:40238089-40238089

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1272A>G; p.P424P; 19:40235139-40235139

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.523G>A; p.G175S; 19:40241988-40241988

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.596C>G; p.T199S; 19:40240088-40240088

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1112G>T; p.R371L; 19:40235953-40235953

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.285G>A; p.E95E; 19:40255160-40255160

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1338G>T; p.Q446H; 19:40235073-40235073

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.622A>G; p.R208G; 19:40240062-40240062

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.609C>T; p.V203V; 19:40240075-40240075

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.268G>T; p.V90L; 19:40255177-40255177

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.510G>T; p.R170R; 19:40242001-40242001

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1184G>T; p.G395V; 19:40235342-40235342

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.240G>T; p.W80C; 19:40255205-40255205

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.239G>T; p.W80L; 19:40255206-40255206

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.627C>T; p.H209H; 19:40240057-40240057

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1350C>A; p.I450I; 19:40235061-40235061

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1112G>A; p.R371H; 19:40235953-40235953

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.574-1G>T; p.?; 19:40240111-40240111

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.423C>T; p.S141S; 19:40242552-40242552

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.461A>G; p.Y154C; 19:40242050-40242050

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1205_1207delAGG; p.E402delE; 19:40235319-40235321

 prostatecarcinomaDeletion - In frame

c.641C>T; p.A214V; 19:40238972-40238972

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.661A>G; p.T221A; 19:40238952-40238952

 prostatecarcinomaSubstitution - Missense

c.195C>A; p.T65T; 19:40255250-40255250

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.1063C>T; p.H355Y; 19:40236002-40236002

 skinmalignant_melanomaSubstitution - Missense

c.1063C>T; p.H355Y; 19:40236002-40236002

 skinmalignant_melanomaSubstitution - Missense

c.1063C>T; p.H355Y; 19:40236002-40236002

 skinmalignant_melanomaSubstitution - Missense

c.1421C>T; p.S474F; 19:40233897-40233897

 skinmalignant_melanomaSubstitution - Missense

c.821G>C; p.R274P; 19:40237979-40237979

 skinmalignant_melanomaSubstitution - Missense

c.482G>T; p.G161V; 19:40242029-40242029

 skinmalignant_melanomaSubstitution - Missense

c.253G>C; p.E85Q; 19:40255192-40255192

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.546C>T; p.I182I; 19:40241965-40241965

 skinmalignant_melanomaSubstitution - coding silent

c.989C>T; p.A330V; 19:40236076-40236076

 skinmalignant_melanomaSubstitution - Missense

c.145C>T; p.L49L; 19:40256956-40256956

 skinmalignant_melanomaSubstitution - coding silent

c.1340C>T; p.S447F; 19:40235071-40235071

 skinmalignant_melanomaSubstitution - Missense

c.1331C>T; p.T444I; 19:40235080-40235080

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.582C>T; p.V194V; 19:40240102-40240102

 skinmalignant_melanomaSubstitution - coding silent

c.568G>A; p.A190T; 19:40241943-40241943

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1040G>A; p.R347H; 19:40236025-40236025

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.508C>T; p.R170W; 19:40242003-40242003

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.74G>A; p.R25Q; 19:40257027-40257027

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.805C>T; p.R269W; 19:40237995-40237995

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.169G>A; p.V57I; 19:40256932-40256932

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.535G>A; p.A179T; 19:40241976-40241976

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.49G>A; p.E17K; 19:40257052-40257052

 thyroidcarcinomaSubstitution - Missense

c.696C>A; p.A232A; 19:40238917-40238917

 thyroidother; neoplasmSubstitution - coding silent

c.639+4A>G; p.?; 19:40240041-40240041

 thyroidcarcinomaUnknown

c.1040G>A; p.R347H; 19:40236025-40236025

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1052A>G; p.Y351C; 19:40236013-40236013

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense