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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

2059

Name

EPS8

Synonymous

epidermal growth factor receptor pathway substrate 8;EPS8;epidermal growth factor receptor pathway substrate 8

Definition

epidermal growth factor receptor kinase substrate 8

Position

12p12.3

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1995T>G; p.G665G; 12:15631491-15631491

 breastcarcinomaSubstitution - coding silent

c.1663G>C; p.D555H; 12:15641736-15641736

 breastcarcinomaSubstitution - Missense

c.287C>G; p.A96G; 12:15669743-15669743

 breastcarcinomaSubstitution - Missense

c.2090G>A; p.R697K; 12:15624362-15624362

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.2449G>A; p.D817N; 12:15621337-15621337

 breastcarcinomaSubstitution - Missense

c.2056C>T; p.Q686*; 12:15624396-15624396

 breastcarcinomaSubstitution - Nonsense

c.982T>C; p.F328L; 12:15658541-15658541

 breastcarcinomaSubstitution - Missense

c.535G>A; p.D179N; 12:15666504-15666504

 breastcarcinomaSubstitution - Missense

c.2452delG; p.E818fs*>5; 12:15621334-15621334

 breastcarcinomaDeletion - Frameshift

c.1313A>T; p.E438V; 12:15650944-15650944

 breastcarcinomaSubstitution - Missense

c.1508A>G; p.H503R; 12:15647187-15647187

 breastcarcinomaSubstitution - Missense

c.2226-3delT; p.?; 12:15623290-15623290

 central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.1324C>G; p.L442V; 12:15650933-15650933

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2447T>C; p.F816S; 12:15621339-15621339

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2366G>T; p.G789V; 12:15621420-15621420

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2044+1G>A; p.?; 12:15631441-15631441

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1321A>G; p.M441V; 12:15650936-15650936

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.694C>T; p.R232*; 12:15665798-15665798

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.856A>T; p.K286*; 12:15660695-15660695

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.204+1G>T; p.?; 12:15670855-15670855

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.2140C>T; p.Q714*; 12:15624312-15624312

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1847G>T; p.R616I; 12:15631639-15631639

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2387T>G; p.I796S; 12:15621399-15621399

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2456G>A; p.G819E; 12:15621330-15621330

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1267G>T; p.E423*; 12:15650990-15650990

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1736T>C; p.F579S; 12:15640788-15640788

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.70T>C; p.S24P; 12:15681292-15681292

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2352G>A; p.L784L; 12:15623161-15623161

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.516+6A>G; p.?; 12:15669381-15669381

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaUnknown

c.919A>G; p.K307E; 12:15660632-15660632

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.230G>A; p.R77Q; 12:15669800-15669800

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecifiedSubstitution - Missense

c.2138G>T; p.R713L; 12:15624314-15624314

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecifiedSubstitution - Missense

c.1927G>T; p.A643S; 12:15631559-15631559

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1434G>C; p.E478D; 12:15650823-15650823

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1262C>T; p.P421L; 12:15650995-15650995

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.744A>G; p.K248K; 12:15662092-15662092

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1998C>T; p.G666G; 12:15631488-15631488

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.781A>G; p.M261V; 12:15662055-15662055

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.793C>T; p.R265C; 12:15662043-15662043

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1179C>A; p.F393L; 12:15654216-15654216

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1300C>T; p.R434C; 12:15650957-15650957

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1300C>T; p.R434C; 12:15650957-15650957

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2311G>A; p.A771T; 12:15623202-15623202

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.749G>T; p.R250M; 12:15662087-15662087

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1711C>T; p.R571*; 12:15640813-15640813

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.2226-6_2226-3delTTTT; p.?; 12:15623290-15623293

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.1712G>A; p.R571Q; 12:15640812-15640812

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2465A>G; p.H822R; 12:15621321-15621321

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2465A>G; p.H822R; 12:15621321-15621321

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.378G>T; p.E126D; 12:15669525-15669525

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.378G>T; p.E126D; 12:15669525-15669525

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1685A>T; p.D562V; 12:15640839-15640839

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1307G>A; p.G436D; 12:15650950-15650950

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.639C>T; p.P213P; 12:15665853-15665853

 large_intestine; rectumNSSubstitution - coding silent

c.1061C>T; p.A354V; 12:15658119-15658119

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.660C>T; p.P220P; 12:15665832-15665832

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.445C>A; p.L149I; 12:15669458-15669458

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.445C>A; p.L149I; 12:15669458-15669458

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.310G>T; p.D104Y; 12:15669720-15669720

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1821G>A; p.Q607Q; 12:15640703-15640703

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1768C>T; p.P590S; 12:15640756-15640756

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2146G>A; p.V716M; 12:15624306-15624306

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.2461A>T; p.S821C; 12:15621325-15621325

 livercarcinomaSubstitution - Missense

c.1903G>T; p.V635F; 12:15631583-15631583

 livercarcinomaSubstitution - Missense

c.1903G>T; p.V635F; 12:15631583-15631583

 livercarcinomaSubstitution - Missense

c.1369G>A; p.A457T; 12:15650888-15650888

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.2129A>G; p.H710R; 12:15624323-15624323

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.793_794insT; p.R265fs*3; 12:15662042-15662043

 lungcarcinoma; adenocarcinomaInsertion - Frameshift

c.1919C>G; p.S640C; 12:15631567-15631567

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2303C>T; p.P768L; 12:15623210-15623210

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.397A>G; p.I133V; 12:15669506-15669506

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.2046A>G; p.R682R; 12:15624406-15624406

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.598A>T; p.R200W; 12:15666441-15666441

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.365A>T; p.K122M; 12:15669665-15669665

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.197G>T; p.R66L; 12:15670863-15670863

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2157C>G; p.I719M; 12:15624295-15624295

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.918T>C; p.G306G; 12:15660633-15660633

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.2226-3delT; p.?; 12:15623290-15623290

 lungcarcinoma; small_cell_carcinomaUnknown

c.131T>G; p.L44R; 12:15681231-15681231

 NSmalignant_melanomaSubstitution - Missense

c.1955C>T; p.A652V; 12:15631531-15631531

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1576G>A; p.E526K; 12:15641823-15641823

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.888G>C; p.E296D; 12:15660663-15660663

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.721G>C; p.A241P; 12:15665771-15665771

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1183A>C; p.N395H; 12:15654212-15654212

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.26C>A; p.P9H; 12:15682926-15682926

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.205-10C>G; p.?; 12:15669835-15669835

 ovaryother; neoplasmUnknown

c.1100T>A; p.M367K; 12:15658080-15658080

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1057A>G; p.S353G; 12:15658123-15658123

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.2422G>A; p.A808T; 12:15621364-15621364

 pancreascarcinomaSubstitution - Missense

c.1434+1G>T; p.?; 12:15650822-15650822

 pancreascarcinoma; ductal_carcinomaUnknown

c.1434+1G>T; p.?; 12:15650822-15650822

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Unknown

c.1906C>A; p.P636T; 12:15631580-15631580

 skinmalignant_melanomaSubstitution - Missense

c.2127C>T; p.F709F; 12:15624325-15624325

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.653C>T; p.P218L; 12:15665839-15665839

 skinmalignant_melanomaSubstitution - Missense

c.973_974CC>TT; p.P325F; 12:15658549-15658550

 skinmalignant_melanomaSubstitution - Missense

c.973_974CC>TT; p.P325F; 12:15658549-15658550

 skinmalignant_melanomaSubstitution - Missense

c.956G>C; p.R319P; 12:15658567-15658567

 skinmalignant_melanomaSubstitution - Missense

c.2305G>A; p.E769K; 12:15623208-15623208

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.1881T>G; p.P627P; 12:15631605-15631605

 skin; upper_legmalignant_melanomaSubstitution - coding silent

c.2004C>T; p.I668I; 12:15631482-15631482

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.2004C>T; p.I668I; 12:15631482-15631482

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1756G>A; p.D586N; 12:15640768-15640768

 skin; trunkmalignant_melanomaSubstitution - Missense

c.229C>T; p.R77W; 12:15669801-15669801

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1771C>T; p.P591S; 12:15640753-15640753

 skinmalignant_melanomaSubstitution - Missense

c.2174C>T; p.S725F; 12:15624278-15624278

 skinmalignant_melanomaSubstitution - Missense

c.1594_1595CC>TT; p.P532F; 12:15641804-15641805

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.508G>A; p.E170K; 12:15669395-15669395

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.230G>T; p.R77L; 12:15669800-15669800

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.367-1G>A; p.?; 12:15669537-15669537

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.1232G>A; p.G411E; 12:15654163-15654163

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1513G>A; p.D505N; 12:15647182-15647182

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1637A>G; p.N546S; 12:15641762-15641762

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.956G>T; p.R319L; 12:15658567-15658567

 skinmalignant_melanomaSubstitution - Missense

c.184A>T; p.I62L; 12:15670876-15670876

 skinmalignant_melanomaSubstitution - Missense

c.87_88CC>TT; p.Q30*; 12:15681274-15681275

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1843C>T; p.P615S; 12:15631643-15631643

 skinmalignant_melanomaSubstitution - Missense

c.1091C>T; p.P364L; 12:15658089-15658089

 soft_tissue; blood_vesselangiosarcomaSubstitution - Missense

c.2194A>G; p.T732A; 12:15624258-15624258

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1292C>T; p.P431L; 12:15650965-15650965

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2312C>T; p.A771V; 12:15623201-15623201

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1711C>T; p.R571*; 12:15640813-15640813

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1961T>A; p.I654K; 12:15631525-15631525

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.466C>T; p.P156S; 12:15669437-15669437

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.592G>A; p.A198T; 12:15666447-15666447

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.592G>A; p.A198T; 12:15666447-15666447

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.963A>G; p.K321K; 12:15658560-15658560

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1055C>G; p.P352R; 12:15658125-15658125

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.991T>G; p.C331G; 12:15658532-15658532

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1599G>C; p.K533N; 12:15641800-15641800

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.158G>A; p.R53Q; 12:15670902-15670902

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2215T>C; p.F739L; 12:15624237-15624237

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2215T>C; p.F739L; 12:15624237-15624237

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2226-3delT; p.?; 12:15623290-15623290

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.230G>A; p.R77Q; 12:15669800-15669800

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.695G>T; p.R232L; 12:15665797-15665797

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.695G>T; p.R232L; 12:15665797-15665797

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.756T>C; p.Y252Y; 12:15662080-15662080

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1255G>C; p.E419Q; 12:15651002-15651002

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1255G>C; p.E419Q; 12:15651002-15651002

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1139C>A; p.S380*; 12:15654256-15654256

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.1251-1G>A; p.?; 12:15651007-15651007

 urinary_tract; bladdercarcinomaUnknown