Entrez Gene

Basic Information
Gene ID	1915
Name	EEF1A1
Synonymous	eukaryotic translation elongation factor 1 alpha 1;EEF1A1;eukaryotic translation elongation factor 1 alpha 1
Definition	CTCL tumor antigen\|EF-1-alpha-1\|EF1a-like protein\|cervical cancer suppressor 3\|elongation factor 1 alpha subunit\|elongation factor 1-alpha 1\|elongation factor Tu\|eukaryotic elongation factor 1 A-1\|eukaryotic translation elongation factor 1 alpha 1-like 14
Position	6q14.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1077T>G; p.P359P; 6:73518217-73518217	breast	carcinoma	Substitution - coding silent
c.1077T>G; p.P359P; 6:73518217-73518217	breast	carcinoma	Substitution - coding silent
c.1077T>G; p.P359P; 6:73518217-73518217	breast	carcinoma	Substitution - coding silent
c.500_501insA; p.Y167fs*1; 6:73519052-73519053	breast	carcinoma	Insertion - Frameshift
c.271G>A; p.D91N; 6:73519390-73519390	breast	carcinoma	Substitution - Missense
c.1138G>C; p.D380H; 6:73518156-73518156	breast	carcinoma	Substitution - Missense
c.1044C>A; p.N348K; 6:73518250-73518250	breast	carcinoma	Substitution - Missense
c.1231_1232insT; p.C411fs*3; 6:73518062-73518063	breast	carcinoma	Insertion - Frameshift
c.563T>C; p.V188A; 6:73518990-73518990	breast	carcinoma	Substitution - Missense
c.943G>C; p.V315L; 6:73518440-73518440	breast	carcinoma	Substitution - Missense
c.943G>C; p.V315L; 6:73518440-73518440	breast	carcinoma	Substitution - Missense
c.20A>G; p.H7R; 6:73520007-73520007	breast	carcinoma	Substitution - Missense
c.1295C>T; p.T432I; 6:73517904-73517904	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1295C>T; p.T432I; 6:73517904-73517904	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1301C>T; p.A434V; 6:73517898-73517898	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.188T>G; p.L63R; 6:73519473-73519473	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1044C>A; p.N348K; 6:73518250-73518250	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.82A>G; p.I28V; 6:73519945-73519945	central_nervous_system; brain	glioma	Substitution - Missense
c.296T>C; p.I99T; 6:73519365-73519365	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.802G>A; p.E268K; 6:73518581-73518581	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1264+3_1266del95; p.?; 6:73517933-73518027	central_nervous_system; brainstem	glioma; astrocytoma_Grade_III	Unknown
c.1264+3_1266del95; p.?; 6:73517933-73518027	central_nervous_system; brainstem	glioma; astrocytoma_Grade_III	Unknown
c.382_383delTC; p.S128fs*25; 6:73519170-73519171	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1355C>A; p.T452N; 6:73517844-73517844	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.986G>A; p.S329N; 6:73518397-73518397	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.269T>C; p.I90T; 6:73519392-73519392	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.316A>G; p.T106A; 6:73519345-73519345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1031T>C; p.V344A; 6:73518263-73518263	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.325-1G>A; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.209G>C; p.G70A; 6:73519452-73519452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.209G>C; p.G70A; 6:73519452-73519452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.754G>A; p.D252N; 6:73518716-73518716	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.325-1G>T; p.?; 6:73519229-73519229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1352T>A; p.V451D; 6:73517847-73517847	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.130A>G; p.K44E; 6:73519897-73519897	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.914G>T; p.G305V; 6:73518469-73518469	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1321G>A; p.V441M; 6:73517878-73517878	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.876C>A; p.V292V; 6:73518507-73518507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.629G>A; p.W210*; 6:73518841-73518841	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.788delC; p.P263fs*27; 6:73518595-73518595	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.830T>G; p.V277G; 6:73518553-73518553	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.134A>C; p.E45A; 6:73519893-73519893	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1133A>C; p.K378T; 6:73518161-73518161	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.271G>A; p.D91N; 6:73519390-73519390	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.827T>C; p.M276T; 6:73518556-73518556	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1061G>A; p.S354N; 6:73518233-73518233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.224T>C; p.I75T; 6:73519437-73519437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.213C>T; p.I71I; 6:73519448-73519448	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.647T>G; p.V216G; 6:73518823-73518823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.354T>C; p.A118A; 6:73519199-73519199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.756T>G; p.D252E; 6:73518714-73518714	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1294A>G; p.T432A; 6:73517905-73517905	liver	carcinoma	Substitution - Missense
c.1084G>T; p.D362Y; 6:73518210-73518210	liver	carcinoma	Substitution - Missense
c.705C>T; p.I235I; 6:73518765-73518765	liver	carcinoma	Substitution - coding silent
c.705C>T; p.I235I; 6:73518765-73518765	liver	carcinoma	Substitution - coding silent
c.1281T>A; p.R427R; 6:73517918-73517918	liver	carcinoma	Substitution - coding silent
c.1281T>A; p.R427R; 6:73517918-73517918	liver	carcinoma	Substitution - coding silent
c.694C>G; p.L232V; 6:73518776-73518776	liver	carcinoma	Substitution - Missense
c.694C>G; p.L232V; 6:73518776-73518776	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.144+1G>A; p.?; 6:73519882-73519882	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.370G>A; p.E124K; 6:73519183-73519183	liver	carcinoma	Substitution - Missense
c.370G>A; p.E124K; 6:73519183-73519183	liver	carcinoma	Substitution - Missense
c.1294A>T; p.T432S; 6:73517905-73517905	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.719G>A; p.R240H; 6:73518751-73518751	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.644A>G; p.K215R; 6:73518826-73518826	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.356G>C; p.G119A; 6:73519197-73519197	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.787C>T; p.P263S; 6:73518596-73518596	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.359T>G; p.V120G; 6:73519194-73519194	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.73G>T; p.G25C; 6:73519954-73519954	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.221A>T; p.D74V; 6:73519440-73519440	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1205T>C; p.V402A; 6:73518089-73518089	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1297G>C; p.V433L; 6:73517902-73517902	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.15G>C; p.K5N; 6:73520012-73520012	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.778G>T; p.G260C; 6:73518605-73518605	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.307A>C; p.I103L; 6:73519354-73519354	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.681G>A; p.T227T; 6:73518789-73518789	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.159C>T; p.S53S; 6:73519502-73519502	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1024G>A; p.A342T; 6:73518359-73518359	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1084G>C; p.D362H; 6:73518210-73518210	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1265-6delT; p.?; 6:73517940-73517940	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1095G>A; p.T365T; 6:73518199-73518199	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.173G>A; p.W58*; 6:73519488-73519488	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.285_286delCA; p.H95fs*15; 6:73519375-73519376	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.622-1G>A; p.?; 6:73518849-73518849	pancreas	carcinoma; ductal_carcinoma	Unknown
c.622-1G>A; p.?; 6:73518849-73518849	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Unknown
c.620A>G; p.N207S; 6:73518933-73518933	pancreas	carcinoma	Substitution - Missense
c.920A>C; p.N307T; 6:73518463-73518463	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.724A>G; p.T242A; 6:73518746-73518746	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.719G>A; p.R240H; 6:73518751-73518751	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.314G>C; p.G105A; 6:73519347-73519347	prostate	carcinoma	Substitution - Missense
c.778G>A; p.G260S; 6:73518605-73518605	skin	malignant_melanoma	Substitution - Missense
c.369T>C; p.F123F; 6:73519184-73519184	skin	malignant_melanoma	Substitution - coding silent
c.369T>C; p.F123F; 6:73519184-73519184	skin	malignant_melanoma	Substitution - coding silent
c.719G>A; p.R240H; 6:73518751-73518751	skin; trunk	malignant_melanoma	Substitution - Missense
c.1216C>T; p.P406S; 6:73518078-73518078	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.196G>A; p.E66K; 6:73519465-73519465	skin	malignant_melanoma	Substitution - Missense
c.794G>A; p.G265D; 6:73518589-73518589	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.933T>G; p.N311K; 6:73518450-73518450	skin; extremity	malignant_melanoma	Substitution - Missense
c.1045C>T; p.H349Y; 6:73518249-73518249	skin	malignant_melanoma	Substitution - Missense
c.1045C>T; p.H349Y; 6:73518249-73518249	skin	malignant_melanoma	Substitution - Missense
c.253T>C; p.Y85H; 6:73519408-73519408	skin	malignant_melanoma	Substitution - Missense
c.110G>A; p.R37K; 6:73519917-73519917	skin	malignant_melanoma	Substitution - Missense
c.666T>A; p.N222K; 6:73518804-73518804	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.121A>T; p.K41*; 6:73519906-73519906	skin	malignant_melanoma	Substitution - Nonsense
c.328G>A; p.D110N; 6:73519225-73519225	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1141C>T; p.R381C; 6:73518153-73518153	soft_tissue; fibrous_tissue_and_uncertain_o	synovial_sarcoma	Substitution - Missense
c.1250A>G; p.D417G; 6:73518044-73518044	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.202G>C; p.E68Q; 6:73519459-73519459	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1265-6delT; p.?; 6:73517940-73517940	stomach	adenocarcinoma	Unknown
c.806C>G; p.T269S; 6:73518577-73518577	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1065C>T; p.A355A; 6:73518229-73518229	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.786T>C; p.V262V; 6:73518597-73518597	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.670A>G; p.S224G; 6:73518800-73518800	thyroid	carcinoma	Substitution - Missense
c.860C>T; p.T287M; 6:73518523-73518523	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1044C>A; p.N348K; 6:73518250-73518250	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.519A>G; p.E173E; 6:73519034-73519034	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1065C>T; p.A355A; 6:73518229-73518229	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1075C>G; p.P359A; 6:73518219-73518219	urinary_tract; bladder	carcinoma	Substitution - Missense
c.271G>A; p.D91N; 6:73519390-73519390	urinary_tract; bladder	carcinoma	Substitution - Missense
c.21T>C; p.H7H; 6:73520006-73520006	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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