Entrez Gene

Basic Information
Gene ID	1894
Name	ECT2
Synonymous	epithelial cell transforming 2;ECT2;epithelial cell transforming 2
Definition	epithelial cell transforming sequence 2 oncogene\|epithelial cell-transforming sequence 2 oncogene\|protein ECT2
Position	3q26.1-q26.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.943C>T; p.R315*; 3:172762940-172762940	bone; femur	chondrosarcoma	Substitution - Nonsense
c.1569T>C; p.F523F; 3:172783843-172783843	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1663C>T; p.R555W; 3:172784734-172784734	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.553C>G; p.H185D; 3:172760225-172760225	breast	carcinoma	Substitution - Missense
c.2622G>A; p.T874T; 3:172820207-172820207	breast	carcinoma	Substitution - coding silent
c.2449A>G; p.K817E; 3:172816724-172816724	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1815-2A>G; p.?; 3:172802614-172802614	breast	carcinoma	Unknown
c.2404A>C; p.T802P; 3:172815700-172815700	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1142C>T; p.S381F; 3:172764444-172764444	breast	carcinoma	Substitution - Missense
c.1948C>G; p.L650V; 3:172802915-172802915	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.2489C>T; p.S830L; 3:172816764-172816764	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.2612G>T; p.R871I; 3:172820197-172820197	breast	carcinoma	Substitution - Missense
c.2501G>A; p.R834K; 3:172816776-172816776	breast	carcinoma	Substitution - Missense
c.1630C>T; p.L544F; 3:172783904-172783904	central_nervous_system; brain	glioma	Substitution - Missense
c.1708C>T; p.P570S; 3:172784779-172784779	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.1708C>T; p.P570S; 3:172784779-172784779	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.95A>T; p.E32V; 3:172754625-172754625	central_nervous_system; brain	glioma	Substitution - Missense
c.1549C>G; p.P517A; 3:172783823-172783823	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.532G>T; p.D178Y; 3:172760204-172760204	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2028G>A; p.R676R; 3:172805745-172805745	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2028G>A; p.R676R; 3:172805745-172805745	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2028G>A; p.R676R; 3:172805745-172805745	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2407T>C; p.S803P; 3:172815703-172815703	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1449G>T; p.K483N; 3:172774016-172774016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2528T>C; p.V843A; 3:172816803-172816803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1916G>A; p.R639Q; 3:172802883-172802883	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.888G>T; p.K296N; 3:172762782-172762782	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.865G>A; p.D289N; 3:172762759-172762759	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2196G>T; p.E732D; 3:172807813-172807813	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.950G>A; p.G317E; 3:172762947-172762947	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1199-7G>C; p.?; 3:172769000-172769000	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1217C>G; p.T406S; 3:172769025-172769025	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.763A>G; p.K255E; 3:172762513-172762513	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2482C>A; p.H828N; 3:172816757-172816757	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1646C>G; p.A549G; 3:172784717-172784717	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1962C>G; p.P654P; 3:172802929-172802929	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.884C>A; p.S295*; 3:172762778-172762778	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.842T>C; p.V281A; 3:172762736-172762736	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1732G>T; p.D578Y; 3:172784803-172784803	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2484C>T; p.H828H; 3:172816759-172816759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2397delA; p.K801fs*25; 3:172815693-172815693	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.532G>T; p.D178Y; 3:172760204-172760204	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2248G>T; p.E750*; 3:172807865-172807865	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2406T>C; p.T802T; 3:172815702-172815702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2406T>C; p.T802T; 3:172815702-172815702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2462G>A; p.R821Q; 3:172816737-172816737	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1946C>T; p.S649F; 3:172802913-172802913	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1040G>A; p.R347H; 3:172764342-172764342	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2537G>A; p.R846H; 3:172816812-172816812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1369C>T; p.R457C; 3:172773936-172773936	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.806A>G; p.Y269C; 3:172762700-172762700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.958A>T; p.M320L; 3:172762955-172762955	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.958A>T; p.M320L; 3:172762955-172762955	large_intestine; colon	carcinoma	Substitution - Missense
c.1179G>A; p.E393E; 3:172764481-172764481	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.888G>T; p.K296N; 3:172762782-172762782	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.803A>C; p.K268T; 3:172762697-172762697	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2512A>G; p.S838G; 3:172816787-172816787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1550C>A; p.P517H; 3:172783824-172783824	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1894G>A; p.A632T; 3:172802861-172802861	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1111C>T; p.R371C; 3:172764413-172764413	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1763C>T; p.P588L; 3:172786523-172786523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2404A>G; p.T802A; 3:172815700-172815700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2404A>G; p.T802A; 3:172815700-172815700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2404A>G; p.T802A; 3:172815700-172815700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.527G>T; p.R176L; 3:172760199-172760199	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.134A>G; p.E45G; 3:172755298-172755298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.134A>G; p.E45G; 3:172755298-172755298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1762C>T; p.P588S; 3:172786522-172786522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2398A>C; p.K800Q; 3:172815694-172815694	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2172C>T; p.A724A; 3:172807789-172807789	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011G>A; p.M337I; 3:172764313-172764313	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.R176*; 3:172760198-172760198	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.591+2T>C; p.?; 3:172760265-172760265	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.2403G>T; p.K801N; 3:172815699-172815699	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2403G>T; p.K801N; 3:172815699-172815699	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1664G>A; p.R555Q; 3:172784735-172784735	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2624T>C; p.L875S; 3:172820209-172820209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.328C>A; p.L110I; 3:172757100-172757100	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2310G>A; p.E770E; 3:172815606-172815606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1004T>C; p.V335A; 3:172764306-172764306	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1574T>G; p.M525R; 3:172783848-172783848	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1574T>G; p.M525R; 3:172783848-172783848	liver	carcinoma	Substitution - Missense
c.320T>C; p.F107S; 3:172757092-172757092	liver	carcinoma	Substitution - Missense
c.106A>T; p.I36F; 3:172754636-172754636	liver	carcinoma	Substitution - Missense
c.106A>T; p.I36F; 3:172754636-172754636	liver	carcinoma	Substitution - Missense
c.2151A>C; p.E717D; 3:172805868-172805868	liver	carcinoma	Substitution - Missense
c.2519A>C; p.D840A; 3:172816794-172816794	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1422C>A; p.I474I; 3:172773989-172773989	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2586C>T; p.V862V; 3:172820171-172820171	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.383A>G; p.Q128R; 3:172757155-172757155	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.922G>T; p.G308*; 3:172762919-172762919	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.821A>T; p.D274V; 3:172762715-172762715	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.274G>C; p.E92Q; 3:172757046-172757046	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1053T>G; p.R351R; 3:172764355-172764355	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.347G>C; p.R116T; 3:172757119-172757119	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2465G>T; p.R822M; 3:172816740-172816740	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2466G>T; p.R822S; 3:172816741-172816741	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.271C>G; p.P91A; 3:172757043-172757043	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.614C>A; p.P205Q; 3:172761632-172761632	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1907C>A; p.S636Y; 3:172802874-172802874	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1754A>T; p.D585V; 3:172786514-172786514	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1993C>A; p.L665I; 3:172802960-172802960	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.785C>A; p.T262N; 3:172762535-172762535	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.852G>C; p.E284D; 3:172762746-172762746	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2471T>C; p.L824P; 3:172816746-172816746	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.438_467del30; p.N147_R156del10; 3:172759024-172759053	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - In frame
c.1435G>T; p.D479Y; 3:172774002-172774002	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1693C>G; p.P565A; 3:172784764-172784764	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.135G>C; p.E45D; 3:172755299-172755299	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2633C>T; p.S878F; 3:172820218-172820218	pancreas	carcinoma	Substitution - Missense
c.656G>A; p.R219Q; 3:172761674-172761674	pancreas	carcinoma	Substitution - Missense
c.1223C>T; p.S408F; 3:172769031-172769031	pancreas	carcinoma	Substitution - Missense
c.952G>A; p.E318K; 3:172762949-172762949	pancreas	other; adenoma	Substitution - Missense
c.1814+1G>A; p.?; 3:172786575-172786575	pancreas	carcinoma	Unknown
c.812C>T; p.P271L; 3:172762706-172762706	prostate	carcinoma	Substitution - Missense
c.715C>T; p.P239S; 3:172762465-172762465	skin	malignant_melanoma	Substitution - Missense
c.2601C>T; p.F867F; 3:172820186-172820186	skin	malignant_melanoma	Substitution - coding silent
c.71C>T; p.S24F; 3:172754601-172754601	skin	malignant_melanoma	Substitution - Missense
c.811C>T; p.P271S; 3:172762705-172762705	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1137C>T; p.S379S; 3:172764439-172764439	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1203C>T; p.T401T; 3:172769011-172769011	skin	malignant_melanoma	Substitution - coding silent
c.1751C>T; p.A584V; 3:172786511-172786511	skin	malignant_melanoma	Substitution - Missense
c.1847C>G; p.A616G; 3:172802648-172802648	skin	malignant_melanoma	Substitution - Missense
c.812C>T; p.P271L; 3:172762706-172762706	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1110C>T; p.P370P; 3:172764412-172764412	skin	malignant_melanoma	Substitution - coding silent
c.950G>A; p.G317E; 3:172762947-172762947	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1423_1424CC>TT; p.P475L; 3:172773990-172773991	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2569C>T; p.P857S; 3:172820154-172820154	skin; neck	malignant_melanoma	Substitution - Missense
c.2569C>T; p.P857S; 3:172820154-172820154	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2408C>T; p.S803L; 3:172815704-172815704	skin	malignant_melanoma	Substitution - Missense
c.2314C>T; p.L772F; 3:172815610-172815610	skin	malignant_melanoma	Substitution - Missense
c.2641C>T; p.H881Y; 3:172820226-172820226	skin	malignant_melanoma	Substitution - Missense
c.621G>A; p.M207I; 3:172761639-172761639	skin	malignant_melanoma	Substitution - Missense
c.1762C>T; p.P588S; 3:172786522-172786522	skin	malignant_melanoma	Substitution - Missense
c.1539delA; p.T515fs*6; 3:172783813-172783813	skin	malignant_melanoma	Deletion - Frameshift
c.123T>A; p.Y41*; 3:172754653-172754653	skin	malignant_melanoma	Substitution - Nonsense
c.190G>A; p.E64K; 3:172755354-172755354	skin	malignant_melanoma	Substitution - Missense
c.2581C>T; p.L861F; 3:172820166-172820166	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2095A>C; p.I699L; 3:172805812-172805812	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1898A>C; p.N633T; 3:172802865-172802865	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1238C>T; p.T413I; 3:172769046-172769046	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1931G>A; p.R644Q; 3:172802898-172802898	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.210+2T>C; p.?; 3:172755376-172755376	stomach	carcinoma; adenocarcinoma	Unknown
c.1316T>C; p.I439T; 3:172769124-172769124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2272C>T; p.R758*; 3:172807889-172807889	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1347A>C; p.V449V; 3:172773914-172773914	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2400A>C; p.K800N; 3:172815696-172815696	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.982A>G; p.T328A; 3:172764284-172764284	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1066C>T; p.L356F; 3:172764368-172764368	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.714T>A; p.P238P; 3:172762464-172762464	thyroid	other; neoplasm	Substitution - coding silent
c.1060G>C; p.E354Q; 3:172764362-172764362	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.99C>G; p.N33K; 3:172754629-172754629	urinary_tract; bladder	carcinoma	Substitution - Missense
c.56C>G; p.S19C; 3:172754586-172754586	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1989C>G; p.L663L; 3:172802956-172802956	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1989C>G; p.L663L; 3:172802956-172802956	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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