Entrez Gene

Basic Information
Gene ID	1326
Name	MAP3K8
Synonymous	mitogen-activated protein kinase kinase kinase 8;MAP3K8;mitogen-activated protein kinase kinase kinase 8
Definition	Ewing sarcoma transformant\|augmented in rheumatoid arthritis 2\|cot (cancer Osaka thyroid) oncogene\|proto-oncogene c-Cot\|proto-oncogene serine/threoine protein kinase\|tumor progression locus 2
Position	10p11.23
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1269T>C; p.I423I; 10:30459497-30459497	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.275C>G; p.S92C; 10:30439213-30439213	breast	carcinoma	Substitution - Missense
c.905G>T; p.R302M; 10:30458115-30458115	breast	carcinoma	Substitution - Missense
c.1382C>T; p.P461L; 10:30460814-30460814	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1382C>T; p.P461L; 10:30460814-30460814	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.497G>T; p.C166F; 10:30447942-30447942	breast	carcinoma	Substitution - Missense
c.1382C>T; p.P461L; 10:30460814-30460814	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1159G>A; p.A387T; 10:30459387-30459387	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.687A>G; p.E229E; 10:30450440-30450440	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1063G>C; p.D355H; 10:30459291-30459291	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.437G>T; p.R146L; 10:30447882-30447882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.494C>T; p.A165V; 10:30447939-30447939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1222C>T; p.R408C; 10:30459450-30459450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1170G>A; p.P390P; 10:30459398-30459398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1280C>T; p.S427L; 10:30460712-30460712	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.97C>A; p.L33I; 10:30439035-30439035	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1348G>A; p.A450T; 10:30460780-30460780	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1346G>C; p.G449A; 10:30460778-30460778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.305G>A; p.R102Q; 10:30439243-30439243	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.941G>C; p.G314A; 10:30458151-30458151	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.91G>A; p.E31K; 10:30439029-30439029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.168C>T; p.N56N; 10:30439106-30439106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.162T>C; p.N54N; 10:30439100-30439100	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1325G>A; p.R442H; 10:30460757-30460757	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.928A>G; p.I310V; 10:30458138-30458138	haematopoietic_and_lymphoid_tissue; tonsil	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.234T>C; p.Y78Y; 10:30439172-30439172	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 10:30458096-30458096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1268T>G; p.I423S; 10:30459496-30459496	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1060G>A; p.A354T; 10:30459288-30459288	large_intestine; colon	carcinoma	Substitution - Missense
c.1060G>A; p.A354T; 10:30459288-30459288	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.212C>A; p.P71Q; 10:30439150-30439150	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.628G>A; p.G210S; 10:30450381-30450381	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1044T>C; p.P348P; 10:30459272-30459272	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.751C>A; p.H251N; 10:30450504-30450504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.600T>C; p.G200G; 10:30450353-30450353	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.I190I; 10:30450323-30450323	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.966G>A; p.T322T; 10:30458176-30458176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.234T>C; p.Y78Y; 10:30439172-30439172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.766+1G>A; p.?; 10:30450520-30450520	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1284C>T; p.C428C; 10:30460716-30460716	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.483G>T; p.K161N; 10:30447928-30447928	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.757G>T; p.D253Y; 10:30450510-30450510	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.P349L; 10:30459274-30459274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.558G>A; p.R186R; 10:30450311-30450311	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.948G>A; p.T316T; 10:30458158-30458158	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.821G>T; p.S274I; 10:30451692-30451692	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.706C>T; p.H236Y; 10:30450459-30450459	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.947C>T; p.T316M; 10:30458157-30458157	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.144C>A; p.T48T; 10:30439082-30439082	liver	carcinoma	Substitution - coding silent
c.374C>T; p.S125F; 10:30447819-30447819	liver	carcinoma	Substitution - Missense
c.247G>T; p.D83Y; 10:30439185-30439185	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1092G>C; p.L364L; 10:30459320-30459320	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.925G>C; p.D309H; 10:30458135-30458135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1164G>C; p.L388L; 10:30459392-30459392	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.826C>T; p.Q276*; 10:30451697-30451697	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.440_441insG; p.A148fs*20; 10:30447885-30447886	lung	carcinoma; non_small_cell_carcinoma	Insertion - Frameshift
c.440_441insG; p.A148fs*20; 10:30447885-30447886	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.59A>G; p.H20R; 10:30438997-30438997	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1190G>A; p.R397H; 10:30459418-30459418	pleura	pulmonary_blastoma	Substitution - Missense
c.1170G>A; p.P390P; 10:30459398-30459398	prostate	carcinoma	Substitution - coding silent
c.426T>A; p.D142E; 10:30447871-30447871	skin	malignant_melanoma	Substitution - Missense
c.1378G>A; p.G460R; 10:30460810-30460810	skin	malignant_melanoma	Substitution - Missense
c.1299G>A; p.E433E; 10:30460731-30460731	skin	malignant_melanoma	Substitution - coding silent
c.424G>T; p.D142Y; 10:30447869-30447869	skin	malignant_melanoma	Substitution - Missense
c.420delT; p.S141fs*18; 10:30447865-30447865	skin	malignant_melanoma	Deletion - Frameshift
c.859C>T; p.L287F; 10:30451730-30451730	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.897C>T; p.I299I; 10:30458107-30458107	skin	malignant_melanoma	Substitution - coding silent
c.1324C>T; p.R442C; 10:30460756-30460756	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1170G>A; p.P390P; 10:30459398-30459398	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1281G>A; p.S427S; 10:30460713-30460713	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1296C>T; p.T432T; 10:30460728-30460728	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.585C>T; p.G195G; 10:30450338-30450338	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1098A>G; p.E366E; 10:30459326-30459326	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1127G>T; p.R376L; 10:30459355-30459355	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1193G>A; p.C398Y; 10:30459421-30459421	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1193G>A; p.C398Y; 10:30459421-30459421	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.37G>C; p.E13Q; 10:30438975-30438975	urinary_tract; bladder	carcinoma	Substitution - Missense
c.127G>C; p.E43Q; 10:30439065-30439065	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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