Entrez Gene

Basic Information
Gene ID	11186
Name	RASSF1
Synonymous	Ras association (RalGDS/AF-6) domain family member 1;RASSF1;Ras association (RalGDS/AF-6) domain family member 1
Definition	WUGSC:H_LUCA12.5\|cardiac-specific ras association domain family 1 protein\|pancreas-specific ras association domain family 1 protein\|ras association domain-containing protein 1\|tumor suppressor protein RDA32
Position	3p21.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.808C>T; p.L270L; 3:50331414-50331414	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.992G>A; p.R331H; 3:50330624-50330624	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.753C>T; p.R251R; 3:50331578-50331578	breast	carcinoma	Substitution - coding silent
c.679C>T; p.R227C; 3:50331652-50331652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.652C>A; p.L218M; 3:50331679-50331679	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1012C>A; p.L338M; 3:50330604-50330604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.928C>T; p.R310C; 3:50330688-50330688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.658G>A; p.V220M; 3:50331673-50331673	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.460C>T; p.L154F; 3:50332064-50332064	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.466A>G; p.M156V; 3:50332058-50332058	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.526C>T; p.R176C; 3:50331805-50331805	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>T; p.R321C; 3:50330655-50330655	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.667C>T; p.R223C; 3:50331664-50331664	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.427A>C; p.I143L; 3:50332097-50332097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.541C>T; p.P181S; 3:50331790-50331790	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.409G>T; p.A137S; 3:50332115-50332115	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1027delC; p.*345fs?; 3:50330589-50330589	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.731G>A; p.R244H; 3:50331600-50331600	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.709T>C; p.F237L; 3:50331622-50331622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.811C>A; p.R271R; 3:50331411-50331411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.753C>T; p.R251R; 3:50331578-50331578	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.387G>T; p.W129C; 3:50332137-50332137	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.813G>A; p.R271R; 3:50331409-50331409	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.43C>T; p.P15S; 3:50340763-50340763	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.278G>A; p.C93Y; 3:50337996-50337996	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.931A>T; p.I311F; 3:50330685-50330685	liver	carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	liver	carcinoma	Substitution - Missense
c.52C>A; p.R18S; 3:50340754-50340754	liver	carcinoma	Substitution - Missense
c.52C>A; p.R18S; 3:50340754-50340754	liver	carcinoma	Substitution - Missense
c.475-1G>C; p.?; 3:50331857-50331857	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.990C>T; p.C330C; 3:50330626-50330626	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.811C>T; p.R271W; 3:50331411-50331411	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.437A>G; p.Y146C; 3:50332087-50332087	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.324C>T; p.P108P; 3:50337950-50337950	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.373G>A; p.E125K; 3:50332151-50332151	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.564C>T; p.S188S; 3:50331767-50331767	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.969C>T; p.I323I; 3:50330647-50330647	skin	malignant_melanoma	Substitution - coding silent
c.475-1G>A; p.?; 3:50331857-50331857	skin	malignant_melanoma	Unknown
c.900C>T; p.F300F; 3:50330716-50330716	skin	malignant_melanoma	Substitution - coding silent
c.668G>A; p.R223H; 3:50331663-50331663	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1023C>T; p.C341C; 3:50330593-50330593	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.751C>T; p.R251C; 3:50331580-50331580	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.680G>A; p.R227H; 3:50331651-50331651	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.928C>T; p.R310C; 3:50330688-50330688	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.613C>T; p.R205C; 3:50331718-50331718	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.941G>A; p.R314Q; 3:50330675-50330675	thyroid	carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	thyroid	other; neoplasm	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	thyroid	other; neoplasm	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	thyroid	other; neoplasm	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.F91S; 3:50338002-50338002	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274A>C; p.T92P; 3:50338000-50338000	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.715G>A; p.V239M; 3:50331616-50331616	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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