Entrez Gene

Basic Information
Gene ID	10642
Name	IGF2BP1
Synonymous	insulin-like growth factor 2 mRNA binding protein 1;IGF2BP1;insulin-like growth factor 2 mRNA binding protein 1
Definition	IGF-II mRNA-binding protein 1\|IGF2 mRNA-binding protein 1\|VICKZ family member 1\|ZBP-1\|coding region determinant-binding protein\|insulin-like growth factor 2 mRNA-binding protein 1\|zipcode-binding protein 1
Position	17q21.32
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.963C>A; p.Y321*; 17:49042263-49042263	autonomic_ganglia	neuroblastoma	Substitution - Nonsense
c.503G>A; p.R168Q; 17:49038269-49038269	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1650A>G; p.Q550Q; 17:49049360-49049360	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.900G>A; p.K300K; 17:49041459-49041459	breast	carcinoma	Substitution - coding silent
c.718G>A; p.A240T; 17:49039991-49039991	breast	carcinoma	Substitution - Missense
c.1621G>A; p.G541R; 17:49046353-49046353	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.911A>C; p.Q304P; 17:49041470-49041470	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1325C>T; p.A442V; 17:49044995-49044995	central_nervous_system; brain	glioma	Substitution - Missense
c.499C>T; p.R167C; 17:49038265-49038265	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.499C>T; p.R167C; 17:49038265-49038265	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.520C>T; p.R174W; 17:49038286-49038286	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.168T>G; p.T56T; 17:48997913-48997913	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.248T>C; p.I83T; 17:49025629-49025629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.592C>A; p.L198I; 17:49038358-49038358	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1227G>T; p.Q409H; 17:49043993-49043993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1596C>T; p.N532N; 17:49046328-49046328	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1227G>A; p.Q409Q; 17:49043993-49043993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1227G>A; p.Q409Q; 17:49043993-49043993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.766G>A; p.A256T; 17:49040039-49040039	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1377G>A; p.P459P; 17:49045047-49045047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.635G>A; p.G212D; 17:49038401-49038401	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1354C>T; p.R452C; 17:49045024-49045024	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1354C>T; p.R452C; 17:49045024-49045024	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.826G>A; p.E276K; 17:49041385-49041385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1002G>T; p.E334D; 17:49042302-49042302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.596G>A; p.R199Q; 17:49038362-49038362	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1314C>T; p.S438S; 17:49044080-49044080	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1207C>A; p.P403T; 17:49043973-49043973	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.304G>C; p.A102P; 17:49026484-49026484	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.941+0delCGTAAGGCTCTCTTCTATTTCCC; p.?; 17:49041500-49041522	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1377G>A; p.P459P; 17:49045047-49045047	kidney	other; neoplasm	Substitution - coding silent
c.421G>A; p.G141S; 17:49038187-49038187	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.990delG; p.A332fs*12; 17:49042290-49042290	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.502C>T; p.R168*; 17:49038268-49038268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1613A>T; p.K538I; 17:49046345-49046345	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.435G>T; p.E145D; 17:49038201-49038201	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>A; p.A237T; 17:49039982-49039982	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>A; p.A237T; 17:49039982-49039982	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>A; p.A237T; 17:49039982-49039982	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.555G>A; p.A185A; 17:49038321-49038321	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056G>T; p.E352D; 17:49042356-49042356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.466G>T; p.D156Y; 17:49038232-49038232	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1489T>G; p.S497A; 17:49045983-49045983	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.595C>T; p.R199W; 17:49038361-49038361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595C>T; p.R199W; 17:49038361-49038361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1550C>T; p.T517M; 17:49046282-49046282	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.A357T; 17:49042369-49042369	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.A357T; 17:49042369-49042369	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>T; p.E267*; 17:49040072-49040072	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.766G>A; p.A256T; 17:49040039-49040039	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.656G>A; p.R219H; 17:49038422-49038422	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.E334K; 17:49042300-49042300	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.521G>A; p.R174Q; 17:49038287-49038287	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.E334K; 17:49042300-49042300	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.521G>A; p.R174Q; 17:49038287-49038287	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1377G>A; p.P459P; 17:49045047-49045047	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1042C>T; p.R348W; 17:49042342-49042342	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.184G>T; p.E62*; 17:48999117-48999117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.84C>A; p.S28S; 17:48997829-48997829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.219G>A; p.S73S; 17:48999152-48999152	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.341A>G; p.N114S; 17:49031913-49031913	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>T; p.E334D; 17:49042302-49042302	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1507A>G; p.I503V; 17:49046001-49046001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.825C>G; p.D275E; 17:49041384-49041384	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.999C>T; p.I333I; 17:49042299-49042299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1298G>T; p.R433L; 17:49044064-49044064	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1571C>T; p.P524L; 17:49046303-49046303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832C>T; p.P278S; 17:49041391-49041391	liver	carcinoma	Substitution - Missense
c.832C>T; p.P278S; 17:49041391-49041391	liver	carcinoma	Substitution - Missense
c.1714G>A; p.A572T; 17:49049424-49049424	liver	carcinoma	Substitution - Missense
c.1714G>A; p.A572T; 17:49049424-49049424	liver	carcinoma	Substitution - Missense
c.608C>A; p.P203H; 17:49038374-49038374	liver	carcinoma	Substitution - Missense
c.1710C>A; p.N570K; 17:49049420-49049420	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.549G>T; p.V183V; 17:49038315-49038315	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.819G>T; p.T273T; 17:49041378-49041378	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1472A>T; p.H491L; 17:49045966-49045966	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1333G>T; p.E445*; 17:49045003-49045003	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1354C>G; p.R452G; 17:49045024-49045024	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1528G>T; p.V510L; 17:49046260-49046260	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.363G>T; p.V121V; 17:49031935-49031935	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1016C>T; p.A339V; 17:49042316-49042316	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1326A>T; p.A442A; 17:49044996-49044996	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.31G>A; p.E11K; 17:48997776-48997776	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.G392E; 17:49043525-49043525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.646G>A; p.A216T; 17:49038412-49038412	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1166G>T; p.S389I; 17:49043516-49043516	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.710C>T; p.A237V; 17:49039983-49039983	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>A; p.P250T; 17:49040021-49040021	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1602G>C; p.Q534H; 17:49046334-49046334	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167H; 17:49038266-49038266	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167H; 17:49038266-49038266	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1470C>A; p.T490T; 17:49045964-49045964	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.155A>G; p.K52R; 17:48997900-48997900	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1269G>A; p.K423K; 17:49044035-49044035	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1269G>A; p.K423K; 17:49044035-49044035	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1269G>A; p.K423K; 17:49044035-49044035	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.37G>A; p.V13M; 17:48997782-48997782	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.958C>A; p.L320I; 17:49042258-49042258	pancreas	carcinoma	Substitution - Missense
c.958C>A; p.L320I; 17:49042258-49042258	pancreas	carcinoma	Substitution - Missense
c.1333G>A; p.E445K; 17:49045003-49045003	pancreas	carcinoma	Substitution - Missense
c.1492G>A; p.A498T; 17:49045986-49045986	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1527G>A; p.T509T; 17:49046021-49046021	pancreas	carcinoma	Substitution - coding silent
c.1721C>T; p.A574V; 17:49049431-49049431	prostate	carcinoma	Substitution - Missense
c.531C>T; p.P177P; 17:49038297-49038297	skin	malignant_melanoma	Substitution - coding silent
c.1725G>A; p.R575R; 17:49049435-49049435	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1528-1G>A; p.?; 17:49046259-49046259	skin; face	carcinoma; squamous_cell_carcinoma	Unknown
c.1634C>T; p.A545V; 17:49046366-49046366	skin	malignant_melanoma	Substitution - Missense
c.936C>T; p.I312I; 17:49041495-49041495	skin	malignant_melanoma	Substitution - coding silent
c.380C>T; p.S127F; 17:49031952-49031952	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1567G>A; p.V523I; 17:49046299-49046299	skin	malignant_melanoma	Substitution - Missense
c.882G>A; p.K294K; 17:49041441-49041441	skin	malignant_melanoma	Substitution - coding silent
c.761C>T; p.S254F; 17:49040034-49040034	skin	malignant_melanoma	Substitution - Missense
c.1425G>A; p.K475K; 17:49045919-49045919	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.941C>T; p.S314L; 17:49041500-49041500	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.941C>T; p.S314L; 17:49041500-49041500	skin	malignant_melanoma	Substitution - Missense
c.1585C>T; p.P529S; 17:49046317-49046317	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1724G>A; p.R575Q; 17:49049434-49049434	skin	malignant_melanoma	Substitution - Missense
c.1608C>T; p.I536I; 17:49046340-49046340	skin	malignant_melanoma	Substitution - coding silent
c.1024G>A; p.E342K; 17:49042324-49042324	skin; trunk	malignant_melanoma	Substitution - Missense
c.1024G>A; p.E342K; 17:49042324-49042324	skin	malignant_melanoma	Substitution - Missense
c.1024G>A; p.E342K; 17:49042324-49042324	skin	malignant_melanoma	Substitution - Missense
c.917C>T; p.T306I; 17:49041476-49041476	skin	malignant_melanoma	Substitution - Missense
c.1673C>G; p.A558G; 17:49049383-49049383	skin	malignant_melanoma	Substitution - Missense
c.1458G>A; p.V486V; 17:49045952-49045952	skin	malignant_melanoma	Substitution - coding silent
c.1442G>A; p.G481D; 17:49045936-49045936	skin	malignant_melanoma	Substitution - Missense
c.1453G>A; p.E485K; 17:49045947-49045947	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1405A>G; p.R469G; 17:49045899-49045899	skin	malignant_melanoma	Substitution - Missense
c.890_891GG>AA; p.R297Q; 17:49041449-49041450	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1354C>T; p.R452C; 17:49045024-49045024	skin	malignant_melanoma	Substitution - Missense
c.256C>T; p.R86*; 17:49025637-49025637	skin	malignant_melanoma	Substitution - Nonsense
c.256C>T; p.R86*; 17:49025637-49025637	skin	malignant_melanoma	Substitution - Nonsense
c.921G>A; p.E307E; 17:49041480-49041480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.588C>T; p.I196I; 17:49038354-49038354	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.499C>T; p.R167C; 17:49038265-49038265	skin	malignant_melanoma	Substitution - Missense
c.484G>A; p.G162R; 17:49038250-49038250	skin	malignant_melanoma	Substitution - Missense
c.224C>T; p.P75L; 17:48999157-48999157	skin	malignant_melanoma	Substitution - Missense
c.850C>T; p.H284Y; 17:49041409-49041409	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.225C>A; p.P75P; 17:48999158-48999158	skin	malignant_melanoma	Substitution - coding silent
c.432G>A; p.L144L; 17:49038198-49038198	skin	malignant_melanoma	Substitution - coding silent
c.748C>A; p.P250T; 17:49040021-49040021	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.283G>A; p.E95K; 17:49025664-49025664	skin	malignant_melanoma	Substitution - Missense
c.1406G>A; p.R469K; 17:49045900-49045900	skin	malignant_melanoma	Substitution - Missense
c.1256C>T; p.A419V; 17:49044022-49044022	skin	malignant_melanoma	Substitution - Missense
c.522G>A; p.R174R; 17:49038288-49038288	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.175+2T>C; p.?; 17:48997922-48997922	stomach	carcinoma; adenocarcinoma	Unknown
c.207G>C; p.E69D; 17:48999140-48999140	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.909G>T; p.E303D; 17:49041468-49041468	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.650C>T; p.T217I; 17:49038416-49038416	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.500G>A; p.R167H; 17:49038266-49038266	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1565T>C; p.V522A; 17:49046297-49046297	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1629C>A; p.F543L; 17:49046361-49046361	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.682A>G; p.K228E; 17:49038448-49038448	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1285A>G; p.K429E; 17:49044051-49044051	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.202T>C; p.L68L; 17:48999135-48999135	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1471C>A; p.H491N; 17:49045965-49045965	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1420C>T; p.L474F; 17:49045914-49045914	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1391T>A; p.F464Y; 17:49045061-49045061	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1642-11_1642delTCTTGCTGCAGA; p.?; 17:49049341-49049352	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.357G>A; p.T119T; 17:49031929-49031929	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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