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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

10419

Name

PRMT5

Synonymous

protein arginine methyltransferase 5;PRMT5;protein arginine methyltransferase 5

Definition

72 kDa ICln-binding protein|HMT1 hnRNP methyltransferase-like 5|SKB1 homolog|histone-arginine N-methyltransferase PRMT5|jak-binding protein 1|protein arginine N-methyltransferase 5|shk1 kinase-binding protein 1 homolog

Position

14q11.2

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1093G>A; p.G365R; 14:22924376-22924376

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.23delG; p.G8fs*13; 14:22929339-22929339

 bone; pelvischondrosarcomaDeletion - Frameshift

c.1080A>G; p.V360V; 14:22924389-22924389

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.31G>T; p.G11W; 14:22929331-22929331

 breastcarcinomaSubstitution - Missense

c.944T>C; p.L315P; 14:22924705-22924705

 breastcarcinomaSubstitution - Missense

c.646C>T; p.H216Y; 14:22926264-22926264

 breastcarcinomaSubstitution - Missense

c.1582C>T; p.P528S; 14:22922557-22922557

 breastcarcinomaSubstitution - Missense

c.115G>C; p.D39H; 14:22928611-22928611

 breastcarcinomaSubstitution - Missense

c.507G>A; p.E169E; 14:22926758-22926758

 breastcarcinomaSubstitution - coding silent

c.759C>T; p.L253L; 14:22926151-22926151

 breastcarcinomaSubstitution - coding silent

c.644A>G; p.N215S; 14:22926266-22926266

 central_nervous_system; braingliomaSubstitution - Missense

c.1861G>A; p.V621I; 14:22920957-22920957

 central_nervous_system; braingliomaSubstitution - Missense

c.614-1G>T; p.?; 14:22926297-22926297

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1096G>A; p.A366T; 14:22924373-22924373

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1199+1G>A; p.?; 14:22924269-22924269

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1697-2A>G; p.?; 14:22922242-22922242

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.298C>T; p.R100C; 14:22928143-22928143

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1204G>C; p.E402Q; 14:22924179-22924179

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.309C>T; p.S103S; 14:22928132-22928132

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.734T>C; p.V245A; 14:22926176-22926176

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.272G>A; p.R91H; 14:22928169-22928169

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1909C>A; p.L637I; 14:22920909-22920909

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.260C>A; p.S87Y; 14:22928181-22928181

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1407T>C; p.T469T; 14:22923129-22923129

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.567G>A; p.W189*; 14:22926552-22926552

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Nonsense

c.248T>C; p.V83A; 14:22928193-22928193

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1223A>T; p.E408V; 14:22924160-22924160

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.143C>T; p.P48L; 14:22928583-22928583

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1338G>A; p.S446S; 14:22924045-22924045

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.856T>C; p.Y286H; 14:22924962-22924962

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1A>G; p.M1V; 14:22929361-22929361

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1007A>G; p.Q336R; 14:22924642-22924642

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1815C>T; p.C605C; 14:22921003-22921003

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1600C>T; p.R534C; 14:22922539-22922539

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.766C>T; p.R256W; 14:22926144-22926144

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1772C>T; p.T591M; 14:22921046-22921046

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.240G>A; p.T80T; 14:22928201-22928201

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.888C>A; p.A296A; 14:22924930-22924930

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1150C>T; p.R384W; 14:22924319-22924319

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.897C>A; p.L299L; 14:22924921-22924921

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1697-2A>C; p.?; 14:22922242-22922242

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.927G>A; p.Q309Q; 14:22924891-22924891

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.239C>T; p.T80M; 14:22928202-22928202

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.366C>A; p.F122L; 14:22927610-22927610

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1396G>A; p.G466R; 14:22923140-22923140

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1042C>T; p.R348*; 14:22924513-22924513

 livercarcinomaSubstitution - Nonsense

c.1042C>T; p.R348*; 14:22924513-22924513

 livercarcinomaSubstitution - Nonsense

c.145C>T; p.R49C; 14:22928581-22928581

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.145C>T; p.R49C; 14:22928581-22928581

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1132G>C; p.A378P; 14:22924337-22924337

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.993C>A; p.P331P; 14:22924656-22924656

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.1443C>A; p.Y481*; 14:22923093-22923093

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1842G>T; p.E614D; 14:22920976-22920976

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.15G>T; p.A5A; 14:22929347-22929347

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.15G>T; p.A5A; 14:22929347-22929347

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.327_328GG>TT; p.Q109>?; 14:22927648-22927649

 lungcarcinoma; adenocarcinomaComplex

c.858C>A; p.Y286*; 14:22924960-22924960

 lungcarcinoma; small_cell_carcinomaSubstitution - Nonsense

c.190G>T; p.G64C; 14:22928536-22928536

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1895C>T; p.S632L; 14:22920923-22920923

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1006C>G; p.Q336E; 14:22924643-22924643

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.659G>A; p.R220H; 14:22926251-22926251

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.658C>T; p.R220C; 14:22926252-22926252

 pancreascarcinomaSubstitution - Missense

c.111G>T; p.G37G; 14:22928615-22928615

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.614-1G>C; p.?; 14:22926297-22926297

 prostatecarcinoma; adenocarcinomaUnknown

c.1543C>T; p.P515S; 14:22922778-22922778

 skinmalignant_melanomaSubstitution - Missense

c.1421C>T; p.P474L; 14:22923115-22923115

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.298C>T; p.R100C; 14:22928143-22928143

 skinmalignant_melanomaSubstitution - Missense

c.1621C>T; p.P541S; 14:22922518-22922518

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.1248C>T; p.V416V; 14:22924135-22924135

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1124C>T; p.S375F; 14:22924345-22924345

 skinmalignant_melanomaSubstitution - Missense

c.443C>T; p.S148F; 14:22927533-22927533

 skinmalignant_melanomaSubstitution - Missense

c.1409C>T; p.S470F; 14:22923127-22923127

 skinmalignant_melanomaSubstitution - Missense

c.13G>A; p.A5T; 14:22929349-22929349

 skinmalignant_melanomaSubstitution - Missense

c.1365C>T; p.H455H; 14:22924018-22924018

 skinmalignant_melanomaSubstitution - coding silent

c.1410C>T; p.S470S; 14:22923126-22923126

 skinmalignant_melanomaSubstitution - coding silent

c.730C>T; p.P244S; 14:22926180-22926180

 skinmalignant_melanomaSubstitution - Missense

c.916G>C; p.D306H; 14:22924902-22924902

 skinmalignant_melanomaSubstitution - Missense

c.364T>A; p.F122I; 14:22927612-22927612

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1490A>G; p.Q497R; 14:22922831-22922831

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1209C>T; p.N403N; 14:22924174-22924174

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.202C>T; p.R68*; 14:22928524-22928524

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.829T>C; p.F277L; 14:22924989-22924989

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1462A>G; p.R488G; 14:22923074-22923074

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.450+2T>C; p.?; 14:22927524-22927524

 stomachcarcinoma; intestinal_adenocarcinomaUnknown

c.20G>T; p.G7V; 14:22929342-22929342

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.20G>T; p.G7V; 14:22929342-22929342

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.736C>T; p.L246F; 14:22926174-22926174

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.206C>G; p.S69*; 14:22928520-22928520

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.496G>A; p.D166N; 14:22926769-22926769

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.955C>G; p.L319V; 14:22924694-22924694

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.955C>G; p.L319V; 14:22924694-22924694

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.955C>G; p.L319V; 14:22924694-22924694

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.143C>A; p.P48Q; 14:22928583-22928583

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1006C>T; p.Q336*; 14:22924643-22924643

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.996C>G; p.I332M; 14:22924653-22924653

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.73G>A; p.E25K; 14:22929289-22929289

 urinary_tract; bladdercarcinomaSubstitution - Missense