Entrez Gene

Basic Information
Gene ID	10276
Name	NET1
Synonymous	neuroepithelial cell transforming 1;NET1;neuroepithelial cell transforming 1
Definition	Rho guanine nucleotide exchange factor (GEF) 8\|guanine nucleotide regulatory protein (oncogene)\|neuroepithelial cell-transforming gene 1 protein\|neuroepithelioma transforming gene 1\|p65 Net1 proto-oncogene protein\|small GTP-binding protein regulator
Position	10p15
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.490A>G; p.I164V; 10:5453307-5453307	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.442G>A; p.D148N; 10:5453259-5453259	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1129A>G; p.I377V; 10:5456180-5456180	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.565G>A; p.D189N; 10:5453519-5453519	breast	carcinoma	Substitution - Missense
c.1396G>A; p.E466K; 10:5456761-5456761	breast	carcinoma	Substitution - Missense
c.919G>A; p.E307K; 10:5455002-5455002	breast	carcinoma	Substitution - Missense
c.134C>T; p.T45M; 10:5451870-5451870	breast	carcinoma	Substitution - Missense
c.1159C>A; p.L387M; 10:5456210-5456210	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.820C>T; p.H274Y; 10:5454478-5454478	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.399G>T; p.Q133H; 10:5452887-5452887	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1419C>A; p.P473P; 10:5456784-5456784	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.918C>T; p.S306S; 10:5455001-5455001	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1619C>A; p.T540N; 10:5456984-5456984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1365A>G; p.P455P; 10:5456730-5456730	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1482A>G; p.E494E; 10:5456847-5456847	kidney	other; neoplasm	Substitution - coding silent
c.1046T>C; p.I349T; 10:5456097-5456097	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.361C>T; p.R121W; 10:5452517-5452517	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.656C>T; p.A219V; 10:5454314-5454314	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.65T>C; p.V22A; 10:5446830-5446830	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.155C>T; p.S52F; 10:5451891-5451891	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.S129S; 10:5452875-5452875	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.11A>G; p.H4R; 10:5446776-5446776	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.279C>T; p.P93P; 10:5452435-5452435	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1086C>T; p.V362V; 10:5456137-5456137	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.718C>A; p.L240I; 10:5454376-5454376	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.500A>G; p.D167G; 10:5453317-5453317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1339_1340insC; p.F449fs*9; 10:5456704-5456705	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.857A>G; p.E286G; 10:5454515-5454515	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.203C>A; p.S68*; 10:5452359-5452359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.391_393delGGT; p.G131delG; 10:5452879-5452881	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.1243C>T; p.R415C; 10:5456608-5456608	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1243C>T; p.R415C; 10:5456608-5456608	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1503A>T; p.R501S; 10:5456868-5456868	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.649C>T; p.L217L; 10:5454307-5454307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.586G>A; p.G196S; 10:5453540-5453540	liver	carcinoma	Substitution - Missense
c.607-1G>T; p.?; 10:5454264-5454264	liver	carcinoma	Unknown
c.607-1G>T; p.?; 10:5454264-5454264	liver	carcinoma	Unknown
c.1593C>T; p.A531A; 10:5456958-5456958	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.227G>C; p.R76T; 10:5452383-5452383	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.597C>A; p.L199L; 10:5453551-5453551	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.906G>C; p.K302N; 10:5454989-5454989	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.106_107delAA; p.R37fs*37; 10:5451842-5451843	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.475G>C; p.E159Q; 10:5453292-5453292	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>A; p.E104K; 10:5452466-5452466	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.921G>T; p.E307D; 10:5455004-5455004	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.624C>G; p.A208A; 10:5454282-5454282	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1386G>A; p.P462P; 10:5456751-5456751	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.918C>T; p.S306S; 10:5455001-5455001	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1405G>A; p.E469K; 10:5456770-5456770	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.49A>G; p.I17V; 10:5446814-5446814	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.33A>G; p.L11L; 10:5446798-5446798	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.107A>C; p.K36T; 10:5451843-5451843	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.808G>T; p.E270*; 10:5454466-5454466	prostate	carcinoma	Substitution - Nonsense
c.864+9T>C; p.?; 10:5454531-5454531	prostate	carcinoma	Unknown
c.1524G>A; p.M508I; 10:5456889-5456889	skin	malignant_melanoma	Substitution - Missense
c.345C>A; p.T115T; 10:5452501-5452501	skin	malignant_melanoma	Substitution - coding silent
c.1211A>T; p.N404I; 10:5456262-5456262	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.721G>A; p.E241K; 10:5454379-5454379	skin	malignant_melanoma	Substitution - Missense
c.1243C>T; p.R415C; 10:5456608-5456608	skin	malignant_melanoma	Substitution - Missense
c.230C>T; p.S77F; 10:5452386-5452386	skin	malignant_melanoma	Substitution - Missense
c.759C>T; p.F253F; 10:5454417-5454417	skin	malignant_melanoma	Substitution - coding silent
c.101G>T; p.S34I; 10:5451837-5451837	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.510T>C; p.S170S; 10:5453327-5453327	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1435A>G; p.T479A; 10:5456800-5456800	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1435A>G; p.T479A; 10:5456800-5456800	stomach	adenocarcinoma	Substitution - Missense
c.428G>A; p.R143K; 10:5452916-5452916	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1095C>T; p.N365N; 10:5456146-5456146	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1095C>T; p.N365N; 10:5456146-5456146	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1059A>G; p.Q353Q; 10:5456110-5456110	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.929A>G; p.Y310C; 10:5455012-5455012	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.329T>C; p.M110T; 10:5452485-5452485	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1031G>A; p.G344E; 10:5455114-5455114	thyroid	other; neoplasm	Substitution - Missense
c.1006C>A; p.H336N; 10:5455089-5455089	thyroid	other; neoplasm	Substitution - Missense
c.1286C>T; p.A429V; 10:5456651-5456651	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1190C>G; p.S397C; 10:5456241-5456241	urinary_tract; bladder	carcinoma	Substitution - Missense
c.763G>C; p.D255H; 10:5454421-5454421	urinary_tract; bladder	carcinoma	Substitution - Missense
c.156_175del20; p.P53fs*15; 10:5451892-5451911	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift

Oncogene database

COSMIC confirmed somatic mutation [Top]

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