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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

1026

Name

CDKN1A

Synonymous

cyclin-dependent kinase inhibitor 1A (p21, Cip1);CDKN1A;cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Definition

CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1

Position

6p21.2

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.184G>T; p.D62Y; 6:36684285-36684285

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.293C>G; p.S98*; 6:36684394-36684394

 breastcarcinomaSubstitution - Nonsense

c.412C>G; p.Q138E; 6:36684513-36684513

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.427C>T; p.R143W; 6:36684528-36684528

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.427C>T; p.R143W; 6:36684528-36684528

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastomaSubstitution - Missense

c.259G>A; p.D87N; 6:36684360-36684360

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.259G>A; p.D87N; 6:36684360-36684360

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.205C>T; p.R69W; 6:36684306-36684306

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.279G>C; p.R93S; 6:36684380-36684380

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.240G>A; p.T80T; 6:36684341-36684341

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.464G>A; p.R155H; 6:36685769-36685769

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.93C>A; p.S31R; 6:36684194-36684194

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.211C>A; p.L71I; 6:36684312-36684312

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.108G>A; p.A36A; 6:36684209-36684209

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.418C>T; p.R140*; 6:36684519-36684519

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.142C>T; p.R48*; 6:36684243-36684243

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.337C>A; p.L113M; 6:36684438-36684438

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.56G>A; p.R19H; 6:36684157-36684157

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.56G>A; p.R19H; 6:36684157-36684157

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.151T>G; p.F51V; 6:36684252-36684252

 livercarcinomaSubstitution - Missense

c.151T>G; p.F51V; 6:36684252-36684252

 livercarcinomaSubstitution - Missense

c.205_206insG; p.L71fs*18; 6:36684306-36684307

 livercarcinoma; hepatocellular_carcinomaInsertion - Frameshift

c.82G>T; p.E28*; 6:36684183-36684183

 livercarcinomaSubstitution - Nonsense

c.139G>T; p.E47*; 6:36684240-36684240

 livercarcinoma; hepatocellular_carcinomaSubstitution - Nonsense

c.85C>T; p.Q29*; 6:36684186-36684186

 livercarcinomaSubstitution - Nonsense

c.256C>T; p.R86W; 6:36684357-36684357

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.486G>T; p.R162S; 6:36685791-36685791

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.317C>T; p.A106V; 6:36684418-36684418

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.59G>A; p.R20H; 6:36684160-36684160

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.279G>T; p.R93S; 6:36684380-36684380

 ovaryother; neoplasmSubstitution - Missense

c.419G>A; p.R140Q; 6:36684520-36684520

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.97G>A; p.D33N; 6:36684198-36684198

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.10C>T; p.P4S; 6:36684111-36684111

 skinmalignant_melanomaSubstitution - Missense

c.474C>T; p.I158I; 6:36685779-36685779

 skinmalignant_melanomaSubstitution - coding silent

c.192C>T; p.A64A; 6:36684293-36684293

 skinmalignant_melanomaSubstitution - coding silent

c.255C>T; p.G85G; 6:36684356-36684356

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.283C>T; p.P95S; 6:36684384-36684384

 skinmalignant_melanomaSubstitution - Missense

c.235C>T; p.P79S; 6:36684336-36684336

 skinmalignant_melanomaSubstitution - Missense

c.246_247CC>TT; p.R83W; 6:36684347-36684348

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.251G>A; p.R84Q; 6:36684352-36684352

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.215G>A; p.G72D; 6:36684316-36684316

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.39C>T; p.C13C; 6:36684140-36684140

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.381T>C; p.A127A; 6:36684482-36684482

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.115G>A; p.A39T; 6:36684216-36684216

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.26G>C; p.R9P; 6:36684127-36684127

 thyroidcarcinomaSubstitution - Missense

c.93C>A; p.S31R; 6:36684194-36684194

 thyroidother; neoplasmSubstitution - Missense

c.166G>T; p.E56*; 6:36684267-36684267

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.182G>T; p.G61V; 6:36684283-36684283

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.248_260del13; p.R83fs*61; 6:36684349-36684361

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaDeletion - Frameshift

c.406G>C; p.D136H; 6:36684507-36684507

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.146G>A; p.W49*; 6:36684247-36684247

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.146G>A; p.W49*; 6:36684247-36684247

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.146G>A; p.W49*; 6:36684247-36684247

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Nonsense

c.146G>A; p.W49*; 6:36684247-36684247

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.394G>T; p.G132C; 6:36684495-36684495

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.6_7delAG; p.E3fs*32; 6:36684107-36684108

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaDeletion - Frameshift

c.44_60del17; p.S15fs*15; 6:36684145-36684161

 urinary_tract; bladdercarcinomaDeletion - Frameshift

c.48_51delGGCC; p.K16fs*14; 6:36684149-36684152

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaDeletion - Frameshift

c.22_25delGTCC; p.Q10fs*20; 6:36684123-36684126

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaDeletion - Frameshift

c.178G>T; p.E60*; 6:36684279-36684279

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.142C>T; p.R48*; 6:36684243-36684243

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.186_187insT; p.A64fs*25; 6:36684287-36684288

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaInsertion - Frameshift

c.186_187insT; p.A64fs*25; 6:36684287-36684288

 urinary_tract; bladdercarcinomaInsertion - Frameshift

c.85C>T; p.Q29*; 6:36684186-36684186

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Nonsense