Entrez Gene

Basic Information
Gene ID	1024
Name	CDK8
Synonymous	cyclin-dependent kinase 8;CDK8;cyclin-dependent kinase 8
Definition	CDK8 protein kinase\|cell division protein kinase 8\|mediator complex subunit CDK8\|mediator of RNA polymerase II transcription subunit CDK8\|protein kinase K35
Position	13q12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1229C>T; p.T410I; 13:26401584-26401584	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.790G>A; p.D264N; 13:26393510-26393510	breast	carcinoma	Substitution - Missense
c.578T>G; p.V193G; 13:26385274-26385274	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.578T>G; p.V193G; 13:26385274-26385274	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.578T>G; p.V193G; 13:26385274-26385274	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.591C>T; p.F197F; 13:26385287-26385287	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.427C>T; p.H143Y; 13:26353851-26353851	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1066C>T; p.R356*; 13:26401303-26401303	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1041C>T; p.A347A; 13:26401278-26401278	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.844G>T; p.D282Y; 13:26396338-26396338	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.557C>T; p.P186L; 13:26385253-26385253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.177C>A; p.I59I; 13:26337615-26337615	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.277G>T; p.V93L; 13:26349144-26349144	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.216G>A; p.E72E; 13:26349083-26349083	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.350A>G; p.N117S; 13:26353774-26353774	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.296A>T; p.Y99F; 13:26349163-26349163	kidney	other; neoplasm	Substitution - Missense
c.1016C>T; p.P339L; 13:26400535-26400535	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.178T>C; p.S60P; 13:26337616-26337616	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1272T>C; p.R424R; 13:26403958-26403958	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.532C>T; p.R178*; 13:26385228-26385228	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.594G>T; p.W198C; 13:26385290-26385290	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.594G>T; p.W198C; 13:26385290-26385290	large_intestine; colon	carcinoma	Substitution - Missense
c.1270C>T; p.R424C; 13:26403956-26403956	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1270C>T; p.R424C; 13:26403956-26403956	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.710G>A; p.R237Q; 13:26393430-26393430	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.796G>T; p.D266Y; 13:26396290-26396290	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>T; p.R237*; 13:26393429-26393429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.337G>A; p.A113T; 13:26353761-26353761	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.471T>G; p.I157M; 13:26382828-26382828	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1326G>C; p.Q442H; 13:26404012-26404012	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.719A>G; p.D240G; 13:26393439-26393439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.893delA; p.K299fs*23; 13:26397185-26397185	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1115A>G; p.N372S; 13:26401470-26401470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.489T>C; p.G163G; 13:26382846-26382846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.517G>A; p.D173N; 13:26385213-26385213	large_intestine; colon	adenoma	Substitution - Missense
c.300T>A; p.A100A; 13:26349167-26349167	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1034delT; p.F346fs*14; 13:26401271-26401271	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.816G>C; p.K272N; 13:26396310-26396310	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>A; p.M273I; 13:26396313-26396313	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.518A>G; p.D173G; 13:26385214-26385214	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.211C>T; p.R71*; 13:26349078-26349078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.698T>G; p.I233R; 13:26393418-26393418	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.402G>T; p.Q134H; 13:26353826-26353826	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.402G>T; p.Q134H; 13:26353826-26353826	large_intestine; colon	carcinoma	Substitution - Missense
c.402G>T; p.Q134H; 13:26353826-26353826	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1280C>T; p.P427L; 13:26403966-26403966	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.128G>A; p.G43E; 13:26254769-26254769	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.967C>T; p.R323*; 13:26400486-26400486	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.967C>T; p.R323*; 13:26400486-26400486	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.584T>C; p.V195A; 13:26385280-26385280	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.598C>T; p.R200*; 13:26385294-26385294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.263A>G; p.H88R; 13:26349130-26349130	liver	carcinoma	Substitution - Missense
c.263A>G; p.H88R; 13:26349130-26349130	liver	carcinoma	Substitution - Missense
c.676G>T; p.E226*; 13:26393396-26393396	liver	carcinoma	Substitution - Nonsense
c.676G>T; p.E226*; 13:26393396-26393396	liver	carcinoma	Substitution - Nonsense
c.934-2A>C; p.?; 13:26400451-26400451	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.307G>A; p.D103N; 13:26349174-26349174	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1326G>A; p.Q442Q; 13:26404012-26404012	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1326G>A; p.Q442Q; 13:26404012-26404012	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1119G>T; p.Q373H; 13:26401474-26401474	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.179C>G; p.S60C; 13:26337617-26337617	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>T; p.G384*; 13:26401505-26401505	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1356G>T; p.Q452H; 13:26404042-26404042	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.374G>T; p.R125L; 13:26353798-26353798	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.49G>A; p.E17K; 13:26254690-26254690	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.464C>T; p.A155V; 13:26382821-26382821	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.565G>A; p.D189N; 13:26385261-26385261	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.565G>A; p.D189N; 13:26385261-26385261	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.514G>A; p.A172T; 13:26382871-26382871	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.993G>T; p.Q331H; 13:26400512-26400512	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.260C>G; p.S87C; 13:26349127-26349127	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1010A>T; p.E337V; 13:26400529-26400529	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.375G>T; p.R125R; 13:26353799-26353799	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1131G>C; p.Q377H; 13:26401486-26401486	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.894A>G; p.E298E; 13:26397186-26397186	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.451G>C; p.D151H; 13:26353875-26353875	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1106A>G; p.D369G; 13:26401343-26401343	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.533G>A; p.R178Q; 13:26385229-26385229	oesophagus	carcinoma	Substitution - Missense
c.778G>A; p.G260R; 13:26393498-26393498	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.613_615delCTT; p.L206delL; 13:26385309-26385311	oesophagus	carcinoma; adenocarcinoma	Deletion - In frame
c.493G>C; p.E165Q; 13:26382850-26382850	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1209A>T; p.K403N; 13:26401564-26401564	pleura	pulmonary_blastoma	Substitution - Missense
c.975C>T; p.T325T; 13:26400494-26400494	skin	malignant_melanoma	Substitution - coding silent
c.849C>T; p.F283F; 13:26396343-26396343	skin; arm	malignant_melanoma	Substitution - coding silent
c.736C>T; p.P246S; 13:26393456-26393456	skin	malignant_melanoma	Substitution - Missense
c.1257C>T; p.T419T; 13:26401612-26401612	skin	malignant_melanoma	Substitution - coding silent
c.892G>A; p.E298K; 13:26397184-26397184	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1032-3C>T; p.?; 13:26401266-26401266	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.373C>T; p.R125W; 13:26353797-26353797	skin	malignant_melanoma	Substitution - Missense
c.1117_1119delCAG; p.Q377delQ; 13:26401472-26401474	skin	malignant_melanoma	Deletion - In frame
c.556C>T; p.P186S; 13:26385252-26385252	skin	malignant_melanoma	Substitution - Missense
c.661G>A; p.G221R; 13:26393381-26393381	skin	malignant_melanoma	Substitution - Missense
c.97G>A; p.G33S; 13:26254738-26254738	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.97G>A; p.G33S; 13:26254738-26254738	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.860+10delA; p.?; 13:26396364-26396364	stomach	adenocarcinoma	Unknown
c.467A>T; p.N156I; 13:26382824-26382824	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.424C>A; p.L142M; 13:26353848-26353848	urinary_tract; bladder	carcinoma	Substitution - Missense
c.88G>T; p.G30C; 13:26254729-26254729	urinary_tract; bladder	carcinoma	Substitution - Missense
c.187G>A; p.A63T; 13:26337625-26337625	urinary_tract; bladder	carcinoma	Substitution - Missense
c.449G>C; p.R150T; 13:26353873-26353873	urinary_tract; bladder	carcinoma	Substitution - Missense
c.102C>T; p.H34H; 13:26254743-26254743	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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