ONGene
Top
Scroll To Top
Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

1019

Name

CDK4

Synonymous

cyclin-dependent kinase 4;CDK4;cyclin-dependent kinase 4

Definition

cell division protein kinase 4

Position

12q14

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.854C>G; p.S285C; 12:57748583-57748583

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.854C>G; p.S285C; 12:57748583-57748583

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.128G>A; p.G43E; 12:57751590-57751590

 breastcarcinoma; HER-positive_carcinomaSubstitution - Missense

c.463A>C; p.K155Q; 12:57750982-57750982

 breastcarcinomaSubstitution - Missense

c.601G>C; p.G201R; 12:57750687-57750687

 breastcarcinomaSubstitution - Missense

c.729C>T; p.S243S; 12:57749272-57749272

 central_nervous_system; braingliomaSubstitution - coding silent

c.729C>T; p.S243S; 12:57749272-57749272

 central_nervous_system; braingliomaSubstitution - coding silent

c.521T>G; p.V174G; 12:57750924-57750924

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.558T>C; p.L186L; 12:57750730-57750730

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.660C>T; p.A220A; 12:57749477-57749477

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.54G>A; p.G18G; 12:57751664-57751664

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.150C>A; p.P50P; 12:57751568-57751568

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.104A>G; p.K35R; 12:57751614-57751614

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.220C>T; p.L74L; 12:57751341-57751341

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - coding silent

c.481C>T; p.L161L; 12:57750964-57750964

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - coding silent

c.481C>T; p.L161L; 12:57750964-57750964

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - coding silent

c.70C>T; p.R24C; 12:57751648-57751648

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.409G>A; p.V137I; 12:57751036-57751036

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.272T>C; p.L91P; 12:57751289-57751289

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.502C>G; p.Q168E; 12:57750943-57750943

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.799T>C; p.S267P; 12:57749202-57749202

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.763C>T; p.R255C; 12:57749238-57749238

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.776C>T; p.S259L; 12:57749225-57749225

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.6T>C; p.A2A; 12:57751712-57751712

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.409G>A; p.V137I; 12:57751036-57751036

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.302G>T; p.R101M; 12:57751259-57751259

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.629G>A; p.R210Q; 12:57750659-57750659

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.873G>A; p.Q291Q; 12:57748564-57748564

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.385G>T; p.D129Y; 12:57751060-57751060

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.4G>A; p.A2T; 12:57751714-57751714

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.416G>A; p.R139Q; 12:57751029-57751029

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.142G>A; p.G48S; 12:57751576-57751576

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.740G>A; p.G247E; 12:57749261-57749261

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.764G>A; p.R255H; 12:57749237-57749237

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.727T>C; p.S243P; 12:57749274-57749274

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.382C>T; p.L128L; 12:57751063-57751063

 livercarcinomaSubstitution - coding silent

c.67G>T; p.A23S; 12:57751651-57751651

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.71G>T; p.R24L; 12:57751647-57751647

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.71G>T; p.R24L; 12:57751647-57751647

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.661G>A; p.D221N; 12:57749476-57749476

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.29C>A; p.A10D; 12:57751689-57751689

 NSmalignant_melanomaSubstitution - Missense

c.25G>A; p.V9M; 12:57751693-57751693

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.131G>A; p.G44E; 12:57751587-57751587

 ovaryother; neoplasmSubstitution - Missense

c.736C>T; p.R246C; 12:57749265-57749265

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.736C>A; p.R246S; 12:57749265-57749265

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.92T>G; p.F31C; 12:57751626-57751626

 prostatecarcinomaSubstitution - Missense

c.633-2A>G; p.?; 12:57749506-57749506

 skincarcinomaUnknown

c.65A>G; p.K22R; 12:57751653-57751653

 skin; head_neckmalignant_melanoma; superficial_spreadingSubstitution - Missense

c.549C>G; p.P183P; 12:57750739-57750739

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.71G>T; p.R24L; 12:57751647-57751647

 skinmalignant_melanomaSubstitution - Missense

c.735C>T; p.P245P; 12:57749266-57749266

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.65A>T; p.K22M; 12:57751653-57751653

 skinmalignant_melanomaSubstitution - Missense

c.65A>T; p.K22M; 12:57751653-57751653

 skinmalignant_melanomaSubstitution - Missense

c.71G>A; p.R24H; 12:57751647-57751647

 skinmalignant_melanomaSubstitution - Missense

c.70C>A; p.R24S; 12:57751648-57751648

 skinmalignant_melanomaSubstitution - Missense

c.70C>T; p.R24C; 12:57751648-57751648

 skinmalignant_melanomaSubstitution - Missense

c.373C>G; p.L125V; 12:57751072-57751072

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.639C>T; p.L213L; 12:57749498-57749498

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.394C>G; p.H132D; 12:57751051-57751051

 urinary_tract; bladdercarcinomaSubstitution - Missense