| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 3932 |
Name | LCK |
Synonym | IMD22|LSK|YT16|p56lck|pp58lck;LCK proto-oncogene, Src family tyrosine kinase;LCK;LCK proto-oncogene, Src family tyrosine kinase |
Definition | T-lymphocyte specific protein tyrosine kinase p56lck|leukocyte C-terminal Src kinase|lymphocyte cell-specific protein-tyrosine kinase|lymphocyte-specific protein tyrosine kinase|p56(LSTRA) protein-tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK |
Position | 1p34.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Regulation of p38-alpha and p38-beta;PID Curated;200054 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | HIV Infection;Reactome;REACT:6185 |
Pathway | Translocation of ZAP-70 to Immunological synapse;PID Reactome;500480 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | role of mef2d in t-cell apoptosis;PID BioCarta;100109 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | Nef and signal transduction;PID Reactome;500755 |
Pathway | IL2 signaling events mediated by STAT5;PID Curated;200158 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Nef Mediated CD4 Down-regulation;PID Reactome;500759 |
Pathway | Glypican 1 network;PID Curated;200021 |
Pathway | Primary immunodeficiency;KEGG PATHWAY;hsa05340 |
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196 |
Pathway | Downstream TCR signaling;PID Reactome;500482 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | il 2 signaling pathway;PID BioCarta;100130 |
Pathway | the co-stimulatory signal during t-cell activation;PID BioCarta;100193 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | PD-1 signaling;PID Reactome;500488 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | TCR signaling;PID Reactome;500478 |
Pathway | Phosphorylation of CD3 and TCR zeta chains;PID Reactome;500479 |
Pathway | il-7 signal transduction;PID BioCarta;100125 |
Pathway | lck and fyn tyrosine kinases in initiation of tcr activation;PID BioCarta;100023 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | Renal Cell cancer;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Lung disease;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Primary tumor;FunDO |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Lymphoma;FunDO |
Disease | Breast cancer;FunDO |
Disease | Combined immunodeficiencies;KEGG DISEASE;H00093 |
Disease | SCID due to LCK deficiency;OMIM |
External Links | |
Links to cell senescence gene database | 3932 |
Links to epithelial mesenchymal transition gene database | 3932 |
Links to ovarian cancer gene database | 3932 |
Links to endometrial cancer gene database | 3932 |
Links to iHOP | 3932 |
Sequence Information | |
Nucleotide Sequence | >3932 : length: 2143 AAGTCAGGGTGGGACGTGGGCGCGGGGAGACAGGTGGTGGCTACGACGGCGAAGGGAGCT GAGACTGTCCAGGCAGCCAGGTTAGGCCAGGAGGACCATGTGAATGGGGCCAGAGGGCTC CCGGGCTGGGCAGGGACCATGGGCTGTGGCTGCAGCTCACACCCGGAAGATGACTGGATG GAAAACATCGATGTGTGTGAGAACTGCCATTATCCCATAGTCCCACTGGATGGCAAGGGC ACGCTGCTCATCCGAAATGGCTCTGAGGTGCGGGACCCACTGGTTACCTACGAAGGCTCC AATCCGCCGGCTTCCCCACTGCAAGGTGACCCCAGGCAGCAGGGCCTGAAAGACAAGGCC TGCGGATCCCTGGCTGTTGGCTTCCACCTCTCCCCCACCTACTTTCTCCCCGGTCTTGCC TTCCTTGTCCCCCACCCTGTAACTCCAGGCTTCCTGCCGATCCCAGCTCGGTTCTCCCTG ATGCCCCTTGTCTTTACAGACAACCTGGTTATCGCTCTGCACAGCTATGAGCCCTCTCAC GACGGAGATCTGGGCTTTGAGAAGGGGGAACAGCTCCGCATCCTGGAGCAGAGCGGCGAG TGGTGGAAGGCGCAGTCCCTGACCACGGGCCAGGAAGGCTTCATCCCCTTCAATTTTGTG GCCAAAGCGAACAGCCTGGAGCCCGAACCCTGGTTCTTCAAGAACCTGAGCCGCAAGGAC GCGGAGCGGCAGCTCCTGGCGCCCGGGAACACTCACGGCTCCTTCCTCATCCGGGAGAGC GAGAGCACCGCGGGATCGTTTTCACTGTCGGTCCGGGACTTCGACCAGAACCAGGGAGAG GTGGTGAAACATTACAAGATCCGTAATCTGGACAACGGTGGCTTCTACATCTCCCCTCGA ATCACTTTTCCCGGCCTGCATGAACTGGTCCGCCATTACACCAGGTACTACAACGGGCAC ACGAAGGTGGCGGTGAAGAGCCTGAAGCAGGGCAGCATGTCCCCGGACGCCTTCCTGGCC GAGGCCAACCTCATGAAGCAGCTGCAACACCAGCGGCTGGTTCGGCTCTACGCTGTGGTC ACCCAGGAGCCCATCTACATCATCACTGAATACATGGAGAATGGGAGTCTAGTGGATTTT CTCAAGACCCCTTCAGGCATCAAGTTGACCATCAACAAACTCCTGGACATGGCAGCCCAA ATTGCAGAAGGCATGGCATTCATTGAAGAGCGGAATTATATTCATCGTGACCTTCGGGCT GCCAACATTCTGGTGTCTGACACCCTGAGCTGCAAGATTGCAGACTTTGGCCTAGCACGC CTCATTGAGGACAACGAGTACACAGCCAGGGAGGGGGCCAAGTTTCCCATTAAGTGGACA GCGCCAGAAGCCATTAACTACGGGACATTCACCATCAAGTCAGATGTGTGGTCTTTTGGG ATCCTGCTGACGGAAATTGTCACCCACGGCCGCATCCCTTACCCAGGGATGACCAACCCG GAGGTGATTCAGAACCTGGAGCGAGGCTACCGCATGGTGCGCCCTGACAACTGTCCAGAG GAGCTGTACCAACTCATGAGGCTGTGCTGGAAGGAGCGCCCAGAGGACCGGCCCACCTTT GACTACCTGCGCAGTGTGCTGGAGGACTTCTTCACGGCCACAGAGGGCCAGTACCAGCCT CAGCCTTGAGAGGCCTTGAGAGGCCCTGGGGTTCTCCCCCTTTCTCTCCAGCCTGACTTG GGGAGATGGAGTTCTTGTGCCATAGTCACATGGCCTATGCACATATGGACTCTGCACATG AATCCCACCCACATGTGACACATATGCACCTTGTGTCTGTACACGTGTCCTGTAGTTGCG TGGACTCTGCACATGTCTTGTACATGTGTAGCCTGTGCATGTATGTCTTGGACACTGTAC AAGGTACCCCTTTCTGGCTCTCCCATTTCCTGAGACCACAGAGAGAGGGGAGAAGCCTGG GATTGACAGAAGCTTCTGCCCACCTACTTTTCTTTCCTCAGATCATCCAGAAGTTCCTCA AGGGCCAGGACTTTATCTAATACCTCTGTGTGCTCCTCCTTGGTGCCTGGCCTGGCACAC ATCAGGAGTTCAATAAATGTCTGTTGATGACTGTTGTACATCT |
Protein Sequence | >3932 : length: 516 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP LQGDPRQQGLKDKACGSLAVGFHLSPTYFLPGLAFLVPHPVTPGFLPIPARFSLMPLVFT DNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSL EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK IRNLDNGGFYISPRITFPGLHELVRHYTRYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP |