| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 57620 |
Name | STIM2 |
Sentence | From PubMed database |
| STIM1 and STIM2 differently regulate endogenous Ca(2+) entry and promote TGF-beta-induced EMT in breast cancer cells. | The Ca(2+) sensor proteins STIM1 and STIM2 are crucial elements of store-operated calcium entry (SOCE) in breast cancer cells. Increased SOCE activity may contribute to epithelial-mesenchymal transitions (EMT) and increase cell migration and invasion. However, the roles of STIM1 and STIM2 in TGF-beta-induced EMT are still unclear. In this study, we demonstrate roles of STIMs in TGF-beta-induced EMT in breast cancer cells. In particular, STIM1 and STIM2 expression affected TGF-beta-induced EMT by mediating SOCE in MDA-MB-231 and MCF-7 breast cancer cells. The specific SOCE inhibitor YM58483 blocked TGF-beta-induced EMT, and differing effects of STIM1 and STIM2 on TGF-beta-induced EMT correlated with differing roles in SOCE. Finally, we showed that STIM2 is associated with non-store-operated calcium entry (non-SOCE) during TGF-beta-induced EMT, whereas STIM1 is not. What's more, non-SOCE have a large possibility to be ROCE. In conclusion, STIM1 and STIM2 proteins play important roles in TGF-beta-induced EMT and these effects are related to both SOCE and non-SOCE.CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. |