Entrez Gene

Basic Information
Gene ID	8878
Name	SQSTM1
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget
Transcription factors [Top]
Links to the hTFtarget for SQSTM1
Links to the AnimalTFDB for SQSTM1
Regulation From TransFac database
p38(m) + p62(h) <==> p38(m):p62(h) (binding)
IRAK1(h) + TRAF6(m) + p62(h) <==> IRAK1(h):TRAF6(m):p62(h) (binding)
TRAF6(m) + p62(h) + RIP(h) <==> TRAF6(m):p62(h):RIP(h) (binding)
p62(h) + RIP(h) + TRAF2(h) <==> p62(h):RIP(h):TRAF2(h) (binding)
p62(h) + RIP(h) <==> p62(h):RIP(h) (binding)
TRADD(h):RIP(h) + p62(h) <==> TRADD(h):RIP(h):p62(h) (binding)
p62(h) + PKCiota(x) <==> p62(h):PKCiota(x) (binding)
p62(h) + PKCzeta(r) <==> p62(h):PKCzeta(r) (binding)
Ajuba(h) + p62(h) <==> Ajuba(h):p62(h) (binding)
p62(h) + Ajuba(h) <==> p62(h):Ajuba(h) (binding)
PKCzeta(h) + Ajuba(h) + p62(h) <==> PKCzeta(h):Ajuba(h):p62(h) (binding)
TRAF6(h) + PKCzeta(h) + Ajuba(h) + p62(h) <==> TRAF6(h):PKCzeta(h):Ajuba(h):p62(h) (binding)
trkA(m.s.) + p62(h) <==> trkA(m.s.):p62(h) (binding)
p75NTR(m.s.) + p62(h) <==> p75NTR(m.s.):p62(h) (binding)
TRAF6(m.s.) + p62(h) <==> TRAF6(m.s.):p62(h) (binding)
p75NTR(m.s.) + TRAF6(m.s.) + p62(h) <==> p75NTR(m.s.):TRAF6(m.s.):p62(h) (binding)
p62(h) + TRAF6(m.s.) + trkA(m.s.) <==> p62(h):TRAF6(m.s.):trkA(m.s.) (binding)
trkA(m.s.) + TRAF6(h) + p62(h) <==> trkA(m.s.):TRAF6(h):p62(h) (binding)
trkB-GP145(r) + TRAF6(h) + p62(h) <==> trkB-GP145(r):TRAF6(h):p62(h) (binding)
Rad23A(h) + p62(h) <==> Rad23A(h):p62(h) (binding)
p62(h) + GATE-16(h) <==> p62(h):GATE-16(h) (binding)
p62(h) + GEC-1(h) <==> p62(h):GEC-1(h) (binding)
p62(h) --> protein remnants (degradation)
p62(h) + bag3(h) <==> p62(h):bag3(h) (binding)
p62(h) + bag3(h) <==> p62(h):bag3(h) (binding)
LC3B(h) + p62(h) <==> LC3B(h):p62(h) (binding)
p62(h) + LC3B(m.s.) <==> p62(h):LC3B(m.s.) (binding)
LC3A(m.s.) + p62(h) <==> LC3A(m.s.):p62(h) (binding)
gabarap(m.s.) + p62(h) <==> gabarap(m.s.):p62(h) (binding)
GEC-1(m.s.) + p62(h) <==> GEC-1(m.s.):p62(h) (binding)
GATE-16(m.s.) + p62(h) <==> GATE-16(m.s.):p62(h) (binding)
LC3B(h) + p62(h) <==> LC3B(h):p62(h) (binding)
p62(h) + Spred-2(m) <==> p62(h):Spred-2(m) (binding)
SQSTM1(h) --> p62(h) (expression).
p62-isoform1(h) + calmodulin(b) <==> p62-isoform1(h):calmodulin(b) (binding)
p62-isoform1(h) + limd1(m.s.) <==> p62-isoform1(h):limd1(m.s.) (binding)
p62-isoform1(h) + TRAF6(m) + Ajuba(h) <==> p62-isoform1(h):TRAF6(m):Ajuba(h) (binding)
p62-isoform1(h) + TRAF6(m.s.) <==> p62-isoform1(h):TRAF6(m.s.) (binding)
Ajuba(h) + p62-isoform1(h) <==> Ajuba(h):p62-isoform1(h) (binding)
p62-isoform1(h) --> TRAF6(m.s.){ub}n (increase of ubiquitination)
p62-isoform1(h) + COUP-TF2(r) <==> p62-isoform1(h):COUP-TF2(r) (binding)
p62-isoform1(h) + trkA(m.s.) <==> p62-isoform1(h):trkA(m.s.) (binding)
SQSTM1(h) --> p62-isoform1(h) (expression).
SQSTM1(h) --> p62-isoform2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
24	Phosphoserine (By similarity).		Swiss-Prot 53.0
148	Phosphotyrosine.		Swiss-Prot 53.0
269	Phosphothreonine.		Swiss-Prot 53.0
272	Phosphoserine.		Swiss-Prot 53.0
332	Phosphoserine.		Swiss-Prot 53.0
365	Phosphoserine (By similarity).		Swiss-Prot 53.0
148	Phosphotyrosine	15592455	Phospho.ELM 6.0
269	Phosphothreonine	16083285;17081983	Phospho.ELM 6.0
272	Phosphoserine	16083285;17081983	Phospho.ELM 6.0
269	Phosphothreonine	16565220	Phospho.ELM 6.0
272	Phosphoserine	16565220	Phospho.ELM 6.0
266	Phosphoserine	17081983	Phospho.ELM 6.0
278	Phosphothreonine	17081983	Phospho.ELM 6.0
328	Phosphoserine	17081983	Phospho.ELM 6.0
332	Phosphoserine	17081983	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr5	Promoter: 179179003 - 179181003	Agilent_014791
chr5	Promoter: 179179003 - 179181003	GSE27584
chr5	Promoter: 179179003 - 179181003	Agilent_014791_44K

Transcription factors [Top]

Post Translational Modification [Top]

Methylation Profile [Top]