| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 8877 |
Name | SPHK1 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for SPHK1 |
| Links to the AnimalTFDB for SPHK1 |
Regulation From TransFac database | ERK2(h) + SK1(h) <==> ERK2(h):SK1(h) (binding) | SK1(h) + ATP --ERK1(h){p}--> SK1(h){p} + ADP (phosphorylation) | SK1(h) + ATP --ERK2(m){p}--> SK1(h){p} + ADP (phosphorylation) | SK1(h) + ATP --Cdk2(h)--> SK1(h){p} + ADP (phosphorylation) | EEF1A(h) + SK1(h) <==> EEF1A(h):SK1(h) (binding) | SPHK1(h) --> SK1(h) (expression). | fenretinide --> SK1(h) (increase of abundance) | Lyn(m) + SK1(h) <==> Lyn(m):SK1(h) (binding) | Lyn(h) + SK1(h) <==> Lyn(h):SK1(h) (binding) | SK1(h) --> EGFR(h){pY} (increase of phosphorylation) | SK1(h) --> ERK1(h){p} (increase of phosphorylation) | SK1(h) --> ERK2(h){p} (increase of phosphorylation) | SK1(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | SK1(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | EEF1A(h) + SK1(h) <==> EEF1A(h):SK1(h) (binding) | SK1(h) + EEF1A(h) <==> SK1(h):EEF1A(h) (binding) | SK1(h) + EF1A2(m) <==> SK1(h):EF1A2(m) (binding) | SK1(h) + ATP --ERK2(m.s.)--> SK1(h){pS225} + ADP (phosphorylation) | EEF1A(h){p} + SK1(h) <==> EEF1A(h){p}:SK1(h) (binding) | ERK1(h) + SK1(h) <==> ERK1(h):SK1(h) (binding) | SPHK1(h) --> SK1(h) (expression). |
Post Translational Modification [Top] | |||
There is no record for SPHK1 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 71890797 - 71892797 | Agilent_014791 |
chr17 |
Promoter: 71890797 - 71892797 | GSE27584 |
chr17 |
Promoter: 71890826 - 71892826 | GSE27584 |