| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 83737 |
Name | ITCH |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for ITCH |
| Links to the AnimalTFDB for ITCH |
Regulation From TransFac database | endophilin A1(m) + itch(h) <==> itch(h):endophilin A1(m) (binding) | itch(h) + endophilin 1(r) <==> itch(h):endophilin 1(r) (binding) | CBL-3(h) + itch(h) <==> CBL-3(h):itch(h) (binding) | itch(h) + JunB(h) <==> itch(h):JunB(h) (binding) | itch(h) --> cxcr4(h) (decrease of protein stability) | itch(h) --> ErbB1(m.s.) (regulation of ubiquitination; regulation of protein activity) | itch(h) + NF-E2 p45(m.s.) <==> itch(h):NF-E2 p45(m.s.) (binding) | atrophin-1(m.s.) + itch(h) <==> atrophin-1(m.s.):itch(h) (binding) | itch(h) + p73alpha(h) <==> itch(h):p73alpha(h) (binding) | itch(h) + p73(h) <==> itch(h):p73(h) (binding) | itch(h) + ErbB4(m.s.) <==> itch(h):ErbB4(m.s.) (binding) | itch(h) + DeltaNp63alpha(h) <==> itch(h):DeltaNp63alpha(h) (binding) | p63gamma(m) + itch(h) <==> p63gamma(m):itch(h) (binding) | p63alpha(m.s.) + itch(h) <==> p63alpha(m.s.):itch(h) (binding) | itch(h) + DeltaNp63alpha(m.s.) <==> itch(h):DeltaNp63alpha(m.s.) (binding) | itch(h) + SRC-1(h) <==> itch(h):SRC-1(h) (binding) | 14-3-3sigma(m.s.) + itch(h) <==> 14-3-3sigma(m.s.):itch(h) (binding) | RIP(h) + itch(h) <==> RIP(h):itch(h) (binding) | ITCH(h) --> itch(h) (expression). | endophilin A1(m) + n ubiquitin(h) --E1(rb),UbcH7(h),itch(h)--> endophilin A1(m){ub(n)} (ubiquitination) | Lyn(m.s.) + ubiquitin(v.s.) --itch(h)--> Lyn(m.s.){ub} (ubiquitination) | Syk(m.s.) + ubiquitin(v.s.) --itch(h)--> Syk(m.s.){ub} (ubiquitination) | ubiquitin(h) + p73alpha(h) --itch(h)--> p73alpha(h){ub} (ubiquitination) | p63alpha(m.s.) + ubiquitin(m.s.) --itch(h)--> p63alpha(m.s.){ub} (ubiquitination) | DeltaNp63alpha(m.s.) + ubiquitin(m.s.) --itch(h)--> DeltaNp63alpha(m.s.){ub} (ubiquitination) | ITCH(h) --> Itch-isoform1(h) (expression). | ITCH(h) --> Itch-isoform2(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 420 | Phosphotyrosine (Fyn) | 16387660 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr20 |
Promoter: 32413245 - 32415245 | Agilent_014791 |
chr20 |
Promoter: 32413245 - 32415245 | GSE27584 |
chr20 |
Promoter: 32413245 - 32415245 | Agilent_014791_44K |