| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 8202 |
Name | NCOA3 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for NCOA3 |
| Links to the AnimalTFDB for NCOA3 |
Regulation From TransFac database | SRC3(h) + NR1B1-isoform1(h) <==> SRC3(h):NR1B1-isoform1(h) (binding). | SRC3(h) + T3R-alpha(r) <==> SRC3(h):T3R-alpha(r) (binding). | SRC3(h) + T3R-beta1(h) <==> SRC3(h):T3R-beta1(h) (binding). | SRC3(h) + VDR(h) <==> SRC3(h):VDR(h) (binding) | SRC3(h) + RXR-alpha(h) <==> SRC3(h):RXR-alpha(h) (binding). | ERR3-isoform1(m) + SRC3(h) <==> ERR3-isoform1(m):SRC3(h) (binding). | SRC3(h) + ER-alpha(h) <==> SRC3(h):ER-alpha(h) (binding) | SRC3(h) --> MTA3(h) (DNA binding) | GR(h) + SRC3(h) <==> GR(h):SRC3(h) (binding) | 14-3-3eta(h) + SRC3(h) <==> 14-3-3eta(h):SRC3(h) (binding) | PPARgamma2(h) + SRC3(h) <==> PPARgamma2(h):SRC3(h) (binding) | p53-isoform1(h) + SRC3(h) <==> p53-isoform1(h):SRC3(h) (binding) | SRC3(h) + c-Ets-1(h) <==> SRC3(h):c-Ets-1(h) (binding) | SRC3(h) + c-Ets-2(h) <==> SRC3(h):c-Ets-2(h) (binding) | SRC3(h) + AR(h) <==> SRC3(h):AR(h) (binding) | SRC3(h) + 6 ATP --> SRC3(h){pT24}{pS505}{pS543}{pS857}{pS860}{pS867} + 6 ADP (phosphorylation) | Ro52(h) + IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CBP(h) + TIF2(h) + SRC3(h) <==> Ro52(h):IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CBP(h):TIF2(h):SRC3(h) (binding) | IKK-gamma(h) + IKK-beta(h) + CBP(h) + SRC3(h) <==> IKK-gamma(h):IKK-beta(h):CBP(h):SRC3(h) (binding) | IKK-gamma(h) + IKK-beta(h) + SRC3(h) <==> IKK-gamma(h):IKK-beta(h):SRC3(h) (binding) | IKK-beta(h) + SRC3(h) <==> IKK-beta(h):SRC3(h) (binding) | IKK-alpha(h) + SRC3(h) <==> IKK-alpha(h):SRC3(h) (binding) | SRC3(h) + IKK-gamma(h) <==> SRC3(h):IKK-gamma(h) (binding) | SRC3(h) + ATP --> SRC3(h){p} + ADP (phosphorylation) | SRC3(h) + carm1(h) <==> SRC3(h):carm1(h) (binding) | SRC3(h) --> cycE(h) (transactivation) | SRC3(h) --> DHFR(h) (transactivation) | SRC3(h) + AR-isoform1(h) <==> SRC3(h):AR-isoform1(h) (binding) | ER-alpha-L(h) + SRC3(h) <==> ER-alpha-L(h):SRC3(h) (binding) | ER-beta(h) + SRC3(h) <==> ER-beta(h):SRC3(h) (binding) | SRC3(h) --> SP-B(h) (transactivation) | SRC3(h) + ER(m.s.) <==> SRC3(h):ER(m.s.) (binding) | CBP(m.s.) + SRC3(h) <==> CBP(m.s.):SRC3(h) (binding) | SRC3(h) + RAR(m.s.) <==> SRC3(h):RAR(m.s.) (binding) | LXR-alpha(h) + SRC3(h) <==> LXR-alpha(h):SRC3(h) (binding) | LXR-beta(h) + SRC3(h) <==> LXR-beta(h):SRC3(h) (binding) | SRC3(h) + ATP --> SRC3(h){pS} + ADP (phosphorylation) | SRC3(h) + ATP --ERK2(m.s.)--> SRC3(h){pS118} + ADP (phosphorylation) | SRC3(h) + acetyl-CoA --> SRC3(h){aceK} + CoA (acetylation) | T3R-beta(h) + SRC3(h) <==> T3R-beta(h):SRC3(h) (binding) | Pin1(h) + SRC3(h) <==> Pin1(h):SRC3(h) (binding) | SRC3(h) + Pin1(h) <==> SRC3(h):Pin1(h) (binding) | PA28g(h) + SRC3(h) <==> PA28g(h):SRC3(h) (binding) | NF-AT4(h) + SRC3(h) <==> NF-AT4(h):SRC3(h) (binding) | tpr(h) + SRC3(h) <==> tpr(h):SRC3(h) (binding) | ZCWCC1(h) + SRC3(h) <==> ZCWCC1(h):SRC3(h) (binding) | NR1B1(h) + SRC3(h) <==> NR1B1(h):SRC3(h) (binding) | SRC3(h) + RAR-gamma(h) <==> SRC3(h):RAR-gamma(h) (binding) | LXR-beta(h) + SRC3(h) <==> LXR-beta(h):SRC3(h) (binding) | SRC3(h) + ERR1(h) <==> SRC3(h):ERR1(h) (binding) | SRC3(h) --/ BTG2(h) (transrepression) | SRC3(h) + atad2(h) <==> SRC3(h):atad2(h) (binding) | SRC3(h) --> ATAD2(h) (transactivation) | SRC3(h) + CHIP(h) <==> SRC3(h):CHIP(h) (binding) | SRC3(h) --> Smad2(h) (increase of abundance) | SRC3(h) --> TWIST(h) (increase of abundance) | SRC3(h) --> SMAD2(h) (transactivation) | SRC3(h) --> IGF1(h) (transactivation) | SRC3(h) --> IGF-1(h) (increase of abundance) | NCOA3(h) --> SRC3(h) (expression). | LRH1-isoform1(h) + SRC3-xbb1(h) <==> LRH1-isoform1(h):SRC3-xbb1(h) (binding) | T3R-alpha(c) + SRC3-xbb1(h) <==> T3R-alpha(c):SRC3-xbb1(h) (binding) | NCOA3(h) --> SRC3-xbb1(h) (expression). | SRC3-isoform1(h) + 6 ATP --> SRC3-isoform1(h){pT24}{pS505}{pS543}{pS857}{pS860}{pS867} + 6 ADP (phosphorylation) | NCOA3(h) --> SRC3-isoform1(h) (expression). | NCOA3(h) --> SRC3-isoform5(h) (expression). | SRC3-xbb2(h) + BAF57(m) <==> SRC3-xbb2(h):BAF57(m) (binding) | NR1B1(h) + SRC3-xbb2(h) <==> NR1B1(h):SRC3-xbb2(h) (binding) | RXR-alpha(h) + SRC3-xbb2(h) <==> RXR-alpha(h):SRC3-xbb2(h) (binding) | VDR(h) + SRC3-xbb2(h) <==> VDR(h):SRC3-xbb2(h) (binding) | T3R-beta(h) + SRC3-xbb2(h) <==> T3R-beta(h):SRC3-xbb2(h) (binding) | PPARalpha(m) + SRC3-xbb2(h) <==> PPARalpha(m):SRC3-xbb2(h) (binding) | SRC3-xbb2(h) + ER(m.s.) <==> SRC3-xbb2(h):ER(m.s.) (binding) | SRC3-xbb2(h) + RelA-p65(h) <==> SRC3-xbb2(h):RelA-p65(h) (binding) | SRC3-xbb2(h) + carm1(m.s.) <==> SRC3-xbb2(h):carm1(m.s.) (binding) | SRC3-xbb2(h) + ATP --ERK(m.s.)--> SRC3-xbb2(h){pS505} + ADP (phosphorylation) | SRC3-xbb2(h) + ATP --GSK3(m.s.)--> SRC3-xbb2(h){pS505} + ADP (phosphorylation) | SRC3-xbb2(h) + 4 ATP --p38(m.s.)--> SRC3-xbb2(h){pS505}{pS543}{pS860}{pS867} + 4 ADP (phosphorylation) | SRC3-xbb2(h) + 5 ATP --JNK(m.s.)--> SRC3-xbb2(h){pT24}{pS505}{pS543}{pS860}{pS867} + 5 ADP (phosphorylation) | SRC3-xbb2(h) + ATP --PKAc(m.s.)--> SRC3-xbb2(h){pS857} + ADP (phosphorylation) | SRC3-xbb2(h) + ATP --IKK(m.s.)--> SRC3-xbb2(h){pS857} + ADP (phosphorylation) | SRC3-xbb2(h) + 6 ATP --> SRC3-xbb2(h){pT24}{pS505}{pS543}{pS857}{pS860}{pS867} + 6 ADP (phosphorylation) | p300(m.s.) + SRC3-xbb2(h) <==> p300(m.s.):SRC3-xbb2(h) (binding) | SRC3-xbb2(h) + ATP --IKK(h)--> SRC3-xbb2(h){pS857} + ADP (phosphorylation) | SRC3-xbb2(h) + 4 ATP --p38(h)--> SRC3-xbb2(h){pS505}{pS543}{pS860}{pS867} + 4 ADP (phosphorylation) | SRC3-xbb2(h) + 5 ATP --> SRC3-xbb2(h){pT24}{pS505}{pS543}{pS857}{pS867} + 5 ADP (phosphorylation) | VDR(h) + SRC3-xbb2(h) <==> VDR(h):SRC3-xbb2(h) (binding) | (VDR(h))2 + SRC3-xbb2(h) <==> (VDR(h))2:SRC3-xbb2(h) (binding) | RXR-alpha(h):VDR(h) + SRC3-xbb2(h) <==> RXR-alpha(h):VDR(h):SRC3-xbb2(h) (binding) | VDR(m) + SRC3-xbb2(h) <==> VDR(m):SRC3-xbb2(h) (binding) | NCOA3(h) --> SRC3-xbb2(h) (expression). | NCOA3(h) --> SRC3-isoform2(h) (expression). | NCOA3(h) --> SRC3-isoform3(h) (expression). | NCOA3(h) --> SRC3-isoform4(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 616 | N6-acetyllysine (by CREBBP). | Swiss-Prot 53.0 | 619 | N6-acetyllysine (by CREBBP). | Swiss-Prot 53.0 | 620 | N6-acetyllysine (by CREBBP). | Swiss-Prot 53.0 | 857 | Phosphoserine. | Swiss-Prot 53.0 | 867 | Phosphoserine. | Swiss-Prot 53.0 | 867 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 24 | Phosphothreonine | 15383283 | Phospho.ELM 6.0 | 860 | Phosphoserine | 15383283 | Phospho.ELM 6.0 | 543 | Phosphoserine | 15383283 | Phospho.ELM 6.0 | 505 | Phosphoserine | 15383283 | Phospho.ELM 6.0 | 857 | Phosphoserine | 15808510 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr20 |
Promoter: 45562564 - 45564564 | Agilent_014791 |
chr20 |
Promoter: 45562564 - 45564564 | GSE27584 |
chr20 |
Promoter: 45562564 - 45564564 | GSE27584 |
chr20 |
Promoter: 45562564 - 45564564 | Agilent_014791_44K |