| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7852 |
Name | CXCR4 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for CXCR4 |
| Links to the AnimalTFDB for CXCR4 |
Regulation From TransFac database | CD26(h) + cxcr4(h) <==> CD26(h):cxcr4(h) (binding) | cxcr4(h) + SDF-1alpha(h) <==> cxcr4(h):SDF-1alpha(h) (binding) | cxcr4(h) + SDF-1alpha(m) <==> cxcr4(h):SDF-1alpha(m) (binding) | cxcr4(h) + ATP --> cxcr4(h){p} + ADP (phosphorylation) | cxcr4(h) + Hip(h) <==> cxcr4(h):Hip(h) (binding) | CD4(h) + cxcr4(h) <==> CD4(h):cxcr4(h) (binding) | SDF-1alpha(h) + cxcr4(h) <==> SDF-1alpha(h):cxcr4(h) (binding) | beta-arrestin2(h) + cxcr4(h) <==> beta-arrestin2(h):cxcr4(h) (binding) | SDF-1alpha(m.s.) + cxcr4(h) <==> SDF-1alpha(m.s.):cxcr4(h) (binding) | cxcr4(h) --> ERK(h){p} (increase of phosphorylation) | CD45(h){pY} + cxcr4(h) <==> CD45(h){pY}:cxcr4(h) (binding) | CD4(h) + PDI(b) + cxcr4(h) <==> CD4(h):PDI(b):cxcr4(h) (binding) | cxcr4(h) + MLC(h) + Myosin-9(h) <==> cxcr4(h):MLC(h):Myosin-9(h) (binding) | cxcr4(h) + Myosin-9(h) + MLC(h) + F-actin(h) <==> cxcr4(h):Myosin-9(h):MLC(h):F-actin(h) (binding) | Myosin-9(h) + cxcr4(h) <==> Myosin-9(h):cxcr4(h) (binding) | SDF-1(h) + cxcr4(h) <==> SDF-1(h):cxcr4(h) (binding) | cxcr4(h) + DHLAG(h) <==> cxcr4(h):DHLAG(h) (binding) | cxcr4(h) + 3 ATP --> cxcr4(h){pS324}{pS325}{pS330} + 3 ADP (phosphorylation) | CXCR4(h) --> cxcr4(h) (expression). | beta-arrestin1(h) --> cxcr4(h) (increase of abundance) | beta-arrestin2(h) --> cxcr4(h) (increase of abundance) | itch(h) --> cxcr4(h) (decrease of protein stability) | CXCR4(h) --> cxcr4-isoform2(h) (expression). | cxcr4-isoform1(h) + 6 ATP --> cxcr4-isoform1(h){pS321}{pS324}{pS325}{pS}3 + 6 ADP (phosphorylation) | cxcr4-isoform1(h) + 4 ATP --> cxcr4-isoform1(h){pS324}{pS325}{pS330}{pS339} + 4 ADP (phosphorylation) | CXCR4(h) --> cxcr4-isoform1(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 11 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 21 | Sulfotyrosine (Potential). | Swiss-Prot 53.0 | 176 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 319 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 346 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 348 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 136589783 - 136591783 | Agilent_014791 |
chr2 |
Promoter: 136591695 - 136593695 | Agilent_014791 |
chr2 |
Promoter: 136589783 - 136591783 | GSE27584 |
chr2 |
Promoter: 136591695 - 136593695 | GSE27584 |
chr2 |
Promoter: 136589783 - 136591783 | PMID:15662133 |
chr2 |
Promoter: 136591695 - 136593695 | PMID:15662133 |