| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7039 |
Name | TGFA |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for TGFA |
| Links to the AnimalTFDB for TGFA |
Regulation From TransFac database | TGFalpha(h) + ErbB2(m.s.):ErbB4(m) <==> TGFalpha(h):ErbB2(m.s.):ErbB4(m) (binding) | TGFalpha(h) + (ErbB1(m.s.))2 <==> TGFalpha(h):(ErbB1(m.s.))2 (binding) | TGFalpha(h) + ErbB1(m.s.):ErbB2(m.s.) <==> TGFalpha(h):ErbB2(m.s.):ErbB1(m.s.) (binding) | TGFalpha(h) --TACE(m)--> TGFalpha-ECD(h) + protein remnants (processing) | TGFalpha(h) --> ERK1(h){p} (increase of phosphorylation) | TGFalpha(h) --> ERK2(h){p} (increase of phosphorylation) | TGFA(h) --> TGFalpha(h) (expression). | TNF-alpha{sol}(h) --> TGFalpha(h) (increase of secretion) | NT(m.s.) --> TGFalpha(h) (increase of secretion) | TGFalpha(h) + MAGI-3(m) <==> TGFalpha(h):MAGI-3(m) (binding) | TGFalpha(h) + MAGI-3-isoform2(m) <==> TGFalpha(h):MAGI-3-isoform2(m) (binding) | TGFalpha(h) + MAGI-2(h) <==> TGFalpha(h):MAGI-2(h) (binding) | TGFalpha(h) --> SRCASM(h){pY} (increase of phosphorylation) | TGFalpha(h) --> ErbB1(h){pY} (increase of phosphorylation) | TGFalpha(h) --> ERK(h){p} (increase of phosphorylation) | TGFalpha(h) --/ RANTES(h) (decrease of abundance) | TGFalpha(h) --/ IL-8(h) (decrease of abundance) | TGFalpha(h) --> s100a11(h) (increase of abundance) | TGFalpha(h) --> TLR5(h) (transactivation) | TGFalpha(h) --> TLR9(h) (transactivation) | TGFalpha(h) --> IL-8(h) (increase of secretion) | TGFalpha(h) --> Beta-defensin2(h) (increase of secretion) | TGFalpha(h) --> DEFB4(h) (transactivation; transactivation) | TGFalpha(h) --> PrPc(h) (increase of abundance) | TGFA(h) --> TGFalpha(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 25 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 153 | S-palmitoyl cysteine. | Swiss-Prot 53.0 | 154 | S-palmitoyl cysteine. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 70633938 - 70635938 | Agilent_014791 |
chr2 |
Promoter: 70633938 - 70635938 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 70633938 - 70635938 | GSE27584 |
chr2 |
Promoter: 70633938 - 70635938 | Agilent_014791_44K |