| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6885 |
Name | MAP3K7 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
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| Links to the hTFtarget for MAP3K7 |
| Links to the AnimalTFDB for MAP3K7 |
Regulation From TransFac database | TAB1(h) + TAK1a(h) <==> TAB1(h):TAK1a(h) (binding) | TAK1a(h) + IKK-alpha(h) <==> TAK1a(h):IKK-alpha(h) (binding) | TAK1a(h) + IKK-beta(h) <==> TAK1a(h):IKK-beta(h) (binding) | Pellino1(h) + TAK1a(h) <==> Pellino1(h):TAK1a(h) (binding) | Pellino2(h) + TAK1a(h) <==> Pellino2(h):TAK1a(h) (binding) | TAK1a(h) + Pellino3-isoform1(h) <==> TAK1a(h):Pellino3-isoform1(h) (binding) | TAK1a(h) + Pellino3-isoform2(h) <==> TAK1a(h):Pellino3-isoform2(h) (binding) | TAK1a(h) + n ubiquitin(h) --> TAK1a(h){ubK158}n (ubiquitination) | TAK1a(h) + n ubiquitin(h) --> TAK1a(h){ub{K63}(n)K158} (ubiquitination) | TAK1a(h) + ATP --> TAK1a(h){pT187} + ADP (phosphorylation) | TAK1a(h) + n ubiquitin(h) --TRAF2(h)--> TAK1a(h){ubK158}n (ubiquitination) | TAK1a(h) + n ubiquitin(h) --TRAF6(h)--> TAK1a(h){ubK158}n (ubiquitination) | TAK1a(h) + n ubiquitin(h) --TRAF2(h)--> TAK1a(h){ub{K63}(n)K158} (ubiquitination) | TAK1a(h) + ubiquitin(h) --TRAF6(h)--> TAK1a(h){ub{K63}(n)K158} (ubiquitination) | MAP3K7(h) --> TAK1a(h) (expression). | MAP3K7(h) --> TAK1b(h) (expression). | MAP3K7(h) --> TAK1c(h) (expression). | MAP3K7(h) --> TAK1d(h) (expression). | TRAF6(h) + TAB1(h) + TAK1(h) <==> TRAF6(h):TAB1(h):TAK1(h) (binding) | TAB2(h) + TAK1(h) <==> TAB2(h):TAK1(h) (binding) | TRAF6(h) + TAB2(h) + TAK1(h) <==> TRAF6(h):TAB2(h):TAK1(h) (binding) | ASK1(h) + TAK1(h) <==> ASK1(h):TAK1(h) (binding) | TAK1(h) + TAB1(h) <==> TAK1(h):TAB1(h) (binding) | RKIP(r) + TAK1(h) <==> RKIP(r):TAK1(h) (binding) | Smad7(h) + TAK1(h) <==> Smad7(h):TAK1(h) (binding) | Smad7(h) + TAK1(h) + TAB1(h) <==> Smad7(h):TAK1(h):TAB1(h) (binding) | TRAF6(m) + TAK1(h) <==> TRAF6(m):TAK1(h) (binding) | RANK(h) + TAK1(h) <==> RANK(h):TAK1(h) (binding) | RANK(h) + TAK1(h) + TAB1(h) <==> RANK(h):TAK1(h):TAB1(h) (binding) | TRAF6(h) + TAK1(h) <==> TRAF6(h):TAK1(h) (binding) | HRS(h) + TAK1(h) <==> HRS(h):TAK1(h) (binding) | TRAF6(h) + TAB2(h) + TAK1(h) + PKR(h) <==> TRAF6(h):TAB2(h):TAK1(h):PKR(h) (binding) | TLR3(h) + TRAF6(h) + TAB2(h) + TAK1(h) <==> TLR3(h):TRAF6(h):TAB2(h):TAK1(h) (binding) | TAK1(h) + TAB3(h) <==> TAK1(h):TAB3(h) (binding) | TAK1(h) + TAB2(h):TAB3(h) <==> TAK1(h):TAB2(h):TAB3(h) (binding) | TRAF6(h) + TAB3(h) + TAK1(h) <==> TRAF6(h):TAB3(h):TAK1(h) (binding) | TRAF2(h) + TAB3(h) + TAK1(h) <==> TRAF2(h):TAB3(h):TAK1(h) (binding) | TRAF2(h) + TAK1(h) <==> TRAF2(h):TAK1(h) (binding) | TAK1(h) + ATP --> TAK1(h){p} + ADP (phosphorylation) | TAK1(h) + ATP --> TAK1(h){pT187} + ADP (phosphorylation; automodification) | TAK1(h) --/ IKK-alpha(h) (decrease of abundance) | TAK1(h) + TRAF6(h) + IRAK1(h) + Pellino3-isoform1(h) <==> TAK1(h):TRAF6(h):IRAK1(h):Pellino3-isoform1(h) (binding) | TAB3(h) + TAK1(h) + TAB1(h) <==> TAB3(h):TAK1(h):TAB1(h) (binding) | TIP27(h) + TAK1(h) <==> TIP27(h):TAK1(h) (binding) | TLR3(h) + TAK1(h) <==> TLR3(h):TAK1(h) (binding) | TAK1(h) + IRAK1(h) <==> TAK1(h):IRAK1(h) (binding) | TAK1(h) + Nod2(h) <==> TAK1(h):Nod2(h) (binding) | IKK-alpha(h) + TAK1(h) <==> IKK-alpha(h):TAK1(h) (binding) | TAB2(h) + TAK1(h) + TRAF6(h) + IRAK1(h) <==> TAB2(h):TAK1(h):TRAF6(h):IRAK1(h) (binding) | TAB2(h) + TAB1(h) + TAK1(h) <==> TAB2(h):TAB1(h):TAK1(h) (binding) | TAK1(h) + rbck1(h) <==> TAK1(h):rbck1(h) (binding) | TAK1(h) + IL-17RD-isoform1(m) <==> TAK1(h):IL-17RD-isoform1(m) (binding) | CIKS-isoform1(h) + TAK1(h) <==> CIKS-isoform1(h):TAK1(h) (binding) | TNFR1(h) + TAK1(h) <==> TNFR1(h):TAK1(h) (binding) | TIP41(h) + TAK1(h) <==> TIP41(h):TAK1(h) (binding) | TAK1(h) + MEKK3(m) <==> TAK1(h):MEKK3(m) (binding) | TAK1(h) + ATP --> TAK1(h){p} + ADP (phosphorylation; automodification) | Hsp90(h) + TAK1(h) <==> Hsp90(h):TAK1(h) (binding) | TAK1(h) + Hsp50(h) <==> TAK1(h):Hsp50(h) (binding) | TAK1(h) + ATP --> TAK1(h){pT187} + ADP (phosphorylation) | CnA(h) + TAB2(h) + TAK1(h) + Calcipressin-1(m) <==> CnA(h):TAB2(h):TAK1(h):Calcipressin-1(m) (binding) | IRAK1(h){ub{K63}(n)} + TAK1(h) + TRAF6(h) + IKK-gamma(h) <==> IRAK1(h){ub{K63}(n)}:TAK1(h):TRAF6(h):IKK-gamma(h) (binding) | IL-17RA(h) + TAK1(h) + CIKS(h) <==> IL-17RA(h):TAK1(h):CIKS(h) (binding) | TAK1(h) --> RelA-p65(h){pS536} (increase of phosphorylation) | TAK1(h) + n ubiquitin(h) --> TAK1(h){ub}n (ubiquitination) | TAK1(h) + n ubiquitin(m.s.) --E1(m.s.),Ubc13(h):Uev1(h),TRAF6(m.s.)--> TAK1(h){ub}n (ubiquitination) | MAP3K7(h) --> TAK1(h) (expression). | MKK6(h) + ATP --TAK1(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(m.s.) + ATP --TAK1(h)--> MKK6(m.s.){p} + ADP (phosphorylation) |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 184 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 187 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 192 | Phosphoserine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 439 | Phosphoserine. | Swiss-Prot 53.0 | 187 | Phosphothreonine (MAP3K7) | 10838074 | Phospho.ELM 6.0 | 192 | Phosphoserine (MAP3K7) | 10838074 | Phospho.ELM 6.0 | 184 | Phosphothreonine (MAP3K7) | 10838074 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr6 |
Promoter: 91352985 - 91354985 | Agilent_014791 |
chr6 |
Promoter: 91353128 - 91355128 | Agilent_014791 |
chr6 |
Promoter: 91352985 - 91354985 | GSE27584 |
chr6 |
Promoter: 91353128 - 91355128 | GSE27584 |
chr6 |
Promoter: 91353128 - 91355128 | GSE27584 |
chr6 |
Promoter: 91353128 - 91355128 | GSE27584 |
chr6 |
Promoter: 91353128 - 91355128 | Agilent_014791_44K |
chr6 |
Promoter: 91353128 - 91355128 | Agilent_014791 |